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Role of calcium independent phospholipase A2 in the pathogenesis of multiple organ failure

Research Project

Project/Area Number 23592666
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionTokyo Medical and Dental University

Principal Investigator

AIBOSHI Junichi  東京医科歯科大学, 医学部附属病院, 講師 (50256913)

Co-Investigator(Kenkyū-buntansha) OTOMO Yasuhiro  東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (40176946)
KOBAYASHI Tetsuyuki  お茶の水女子大学, 人間文化創成科学研究科, 教授 (50178323)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywordsカルシウム非依存性ホスホリパーゼA2 / 脂質メディエータ / 出血性ショック / 腸管虚血再潅流 / 多臓器不全 / 腸間膜リンパ液 / 好中球 / カルシウム非依存性ホスホリパーゼA2 / 急性炎症 / 多臓器障害 / リゾリン脂質 / アラキドン酸
Research Abstract

We have identified biologically active lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE) with unsaturated fatty acids (arachidonic acid and linoleic acid) in mesenteric lymph following hemorrhagic shock in rats. It is possible that iPLA2 gamma, the isoform of iPLA2, is involved in the production of these lipid mediators. In addition, we have shown that the iPLA2 gamma specific inhibitor decreases LPC with unsaturated fatty acids in mesenteric lymph and attenuates lung injury after hemorrhagic shock. Also the inhibitor selective for iPLA2 gamma, but not iPLA2 beta and cPLA2, completely inhibited human PMN cytotoxicity (superoxide production, elastase release, and chemotaxis) through receptor signal pathway.
The iPLA2 gamma enzyme is activated in the early phase of inflammatory process and regulates PMN cytotoxicity being crucial during inflammation. This enzyme thereby may be closely related to acute inflammation.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (19 results)

All 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (16 results) Remarks (1 results)

  • [Journal Article] Group VIB Ca2+-independent phospholipase A2γ is associated with acute lung injury following trauma and hemorrhagic shock2013

    • Author(s)
      K. Morishita, J. Aiboshi, T. Kobayashi, Y. Yokoyama, S. Mikami, J. Kumagai, K. Onisawa, Y. Otomo
    • Journal Title

      Journal of Trauma and Acute Care Surgery

      Volume: 75 Issue: 5 Pages: 767-774

    • DOI

      10.1097/ta.0b013e3182a924f2

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lipidomics analysis of mesenteric lymph after trauma and hemorrhagic shock2012

    • Author(s)
      Koji Morishita, Junichi Aiboshi, Tetsuyuki Kobayashi, Saori Mikami, Yuri Yokoyama, Kaori Ogawa, Hiroyuki Yokota, Yasuhiro Otomo
    • Journal Title

      J Trauma Acute Care Surg

      Volume: 72 Issue: 6 Pages: 1541-1547

    • DOI

      10.1097/ta.0b013e318256df15

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 外傷性出血性ショックの多臓器障害におけるカルシウム非依存性ホスホリパーゼA2γの関与2013

    • Author(s)
      小島光暁
    • Organizer
      第41回日本救急医学会総会・学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2013-10-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 外傷出血性ショックの多臓器障害におけるカルシウム非依存性ホスホリパーゼA2γの関与2013

    • Author(s)
      小島光暁、相星淳一、篠美和、三上さおり、小林哲幸、大友康裕
    • Organizer
      第41回日本救急医学会総会・学術集会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒト好中球の生物活性発現とカルシウム非依存性ホスホリパーゼ2012

    • Author(s)
      三上さおり
    • Organizer
      日本麻酔科学会第59回学術集会
    • Place of Presentation
      兵庫県
    • Year and Date
      2012-06-08
    • Related Report
      2013 Final Research Report
  • [Presentation] ラット外傷性出血性ショック後の腸間膜リンパ液中の脂質メディエータとカルシウム非依存性ホスホリパーゼA2γ2012

    • Author(s)
      小島光暁
    • Organizer
      第27回日本ショック学会総会・学術集会
    • Place of Presentation
      東京都
    • Related Report
      2013 Final Research Report
  • [Presentation] ラット外傷出血性ショック後の腸間膜リンパ液中の脂質メディエータとカルシウム非依存性ホスホリパーゼA2γ2012

    • Author(s)
      小島光暁、相星淳一、森下幸治、小林哲幸、横山友里、三上さおり、大友康裕
    • Organizer
      第27回日本ショック学会総会
    • Place of Presentation
      東京都
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒト好中球の生物活性発現とカルシウム非依存性ホスホリパーゼ2012

    • Author(s)
      三上さおり、相星淳一、森下幸治、横山友里、小林哲幸、大友康裕
    • Organizer
      第59回日本麻酔科学会学術集会
    • Place of Presentation
      兵庫県
    • Related Report
      2012 Research-status Report
  • [Presentation] 好中球の生物活性発現にカルシウム非依存性ホスホリパーゼA2(iPLA2)が関与する2011

    • Author(s)
      三上さおり
    • Organizer
      第39回日本救急医学会総会・学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2011-10-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 腸管虚血再潅流後の臓器障害の発生機序におけるカルシウム非依存性ホスホリパーゼA2の関連性2011

    • Author(s)
      竹内彬
    • Organizer
      第39回日本救急医学会総会・学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2011-10-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Group VIB Ca^<2+>-Independent Phospholipase A2γは外傷性出血性ショック後の急性肺障害に関連する2011

    • Author(s)
      森下幸治
    • Organizer
      第39回日本救急医学会総会・学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2011-10-18
    • Related Report
      2013 Final Research Report
  • [Presentation] ラット出血性ショックにおけるカルシウム非依存性ホスホリパーゼA2の関与2011

    • Author(s)
      横山友里
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都府
    • Year and Date
      2011-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Group VIB phospholipase A2 is associated with acute lung injury following trauma and hemorrhagic shock2011

    • Author(s)
      K. Morishita
    • Organizer
      70th Annual Meeting of the American Association for the Surgery of Trauma
    • Place of Presentation
      米国イリノイ州シカゴ
    • Year and Date
      2011-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] ラット出血性ショックにおけるカルシウム非依存性ホスホリパーゼA2の関与2011

    • Author(s)
      横山 友里
    • Organizer
      第84回日本生化学大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2011 Research-status Report
  • [Presentation] Group VIB Ca2+ - Independent PhospholipaseA2γは外傷性出血性ショック後の急性肺障害に関連する2011

    • Author(s)
      森下 幸治
    • Organizer
      第39回日本救急医学会総会
    • Place of Presentation
      新宿京王プラザホテル(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] 好中球の生物活性発現にカルシウム非依存性ホスホリパーゼA2(iPLA2)が関与する2011

    • Author(s)
      三上 さおり
    • Organizer
      第39回日本救急医学会総会
    • Place of Presentation
      新宿京王プラザホテル(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] 腸管虚血再潅流後の臓器障害の発生機序におけるカルシウム非依存性ホスホリパーゼA2の関連性2011

    • Author(s)
      竹内 彬
    • Organizer
      第39回日本救急医学会総会
    • Place of Presentation
      新宿京王プラザホテル(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] Group VIB phospholipase A2 is associated with acute lung injury following trauma and hemorrhagic shock2011

    • Author(s)
      Koji Morishita
    • Organizer
      70th Annual Meeting of the American Association for the Surgery of Trauma
    • Place of Presentation
      シカゴ(米国)
    • Related Report
      2011 Research-status Report
  • [Remarks] 日本麻酔科学会第59回学術集会 救急・ICU(基礎)部門最優秀演題賞受賞 受賞演題「ヒト好中球の生物活性発現とカルシウム非依存性ホスホリパーゼ」

    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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