Resarch for the cellular effects of a Sarin-like organophospherous agent through cytoskeletons.

Research Project

Project/Area Number	23592669
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Emergency medicine
Research Institution	Hiroshima Cosmopolitan University (2012-2014) Hiroshima University (2011)
Principal Investigator	MAKITA Ryosuke 広島都市学園大学, 健康科学部, 准教授 (20321812)
Co-Investigator(Kenkyū-buntansha)	NAGAO Masataka 広島大学, 医歯薬学総合研究科, 教授 (80227991)
Project Period (FY)	2011-04-28 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	神経剤 / 法医学 / 救急医学 / 急性中毒学 / 細胞毒性 / 急性中毒顎
Outline of Final Research Achievements	To determine cellular mechanisms of poisoning by organophosperous agents Sarin and Soman, we analyzed effects of BIMP to culture cell-lines from human nervous system. By immunocytochemistry and Western-blotting, we obtained results that BIMP destabilized polymerization of cytoskeletons of the cells. However, the results were instable itself; we failed to obtain repeatability of the results between our experiences.

Report

(5 results)