| Project/Area Number |
23592671
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KINOSHITA Yoshihiro 熊本大学, 大学院生命科学研究部, 教授 (30195341)
KAMOHARA Hidenobu 熊本大学, 大学院生命科学研究部, 准教授 (90398222)
HIROSAKO Susumu 熊本大学, 大学院生命科学研究部, 助教 (70432995)
SAKAI Keisuke 熊本大学, 医学部附属病院, 助教 (10433038)
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| Co-Investigator(Renkei-kenkyūsha) |
ARAKAWA Hirofumi 国立がんセンター, 生物物理部, 部長 (70313088)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ARDS / Exosome / microRNA / Serum / Profiling / exosome / 実験医学 / 集中治療医学 / SIRS |
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| Outline of Final Research Achievements |
ARDS (Acute Respiratory Distress Syndrome) is severe acute respiratory failure which has been not effective medeicnes. All biological phenomenon is regulated by various proteins and RNAs expression. MicroRNA worked as a RNA interference negatively. Great discovery of microRNA was awarded as the Novel Prize in 2006. In the present study, we identified ARDS related multiple microRNAs was associated about direct ARDS (pulmonary origin) and indirect ARDS (extrapulmonary origin). We also discovered fibrosis related microRNAs in chronic sustained ARDS and its mortality related microRNAs. In our next plans, some clinical results will be confirmed statistically by large number of enrolled patients, and targeting novel microRNAs will be utilized for clinical diagnosis and treatment for ARDS after identification of microRNAs.functions.
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