Cartducin, a cartilage-derived multifunctional factor, regulates testosterone production
| Project/Area Number |
23592762
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Osaka University |
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Principal Investigator |
MAEDA TAKASHI 大阪大学, 歯学研究科, 准教授 (80324789)
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| Co-Investigator(Kenkyū-buntansha) |
FURUKAWA Souhei 大阪大学, 大学院歯学研究科, 教授 (80173524)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | カートデューシン / 精巣 / ライディッヒ細胞 / アンドロゲン / テストステロン / Cartducin / CTRP3 / 骨代謝 |
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| Outline of Final Research Achievements |
We showed that Cartducin is expressed in testicular Leydig cells. Moreover, our results are the first evidence for a direct role of Cartducin in the control of testicular testosterone production. The stimulatory effect of Cartducin on testosterone production is linked to increase in key steroidogenic molecules through the cAMP/PKA signaling pathway. Our results demonstrate a physiological role for Cartducin in testicular steroidogenesis and provide novel insights in the intracellular mechanisms activated by this protein.
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Report
(5 results)
Research Products
(5 results)
