Cartducin, a cartilage-derived multifunctional factor, regulates testosterone production

• Project/Area Number: 23592762
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Osaka University
• Principal Investigator: MAEDA TAKASHI 大阪大学, 歯学研究科, 准教授 (80324789)
• Co-Investigator(Kenkyū-buntansha): FURUKAWA Souhei 大阪大学, 大学院歯学研究科, 教授 (80173524)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: カートデューシン / 精巣 / ライディッヒ細胞 / アンドロゲン / テストステロン / Cartducin / CTRP3 / 骨代謝

Outline of Final Research Achievements

We showed that Cartducin is expressed in testicular Leydig cells. Moreover, our results are the first evidence for a direct role of Cartducin in the control of testicular testosterone production. The stimulatory effect of Cartducin on testosterone production is linked to increase in key steroidogenic molecules through the cAMP/PKA signaling pathway. Our results demonstrate a physiological role for Cartducin in testicular steroidogenesis and provide novel insights in the intracellular mechanisms activated by this protein.

Research Products

• [Journal Article] A novel adipokine C1q/TNF-related protein 1 (CTRP1) regulates chondrocyte proliferation and maturation through the ERK1/2 signaling pathway. (2013)
  • Author(s): Akiyama H, Otani M, Sato S, Toyosawa S, Furukawa S, Wakisaka S, Maeda T
  • Journal Title: Mol. Cell. Endocrinol. Volume: 369 Issue: 1-2 Pages: 63-71
  • DOI: 10.1016/j.mce.2013.01.002
  • Peer Reviewed
• [Journal Article] The adiponectin paralog C1q/TNF-related protein 3 (CTRP3) stimulates testosterone production through the cAMP/PKA signaling pathway (2012)
  • Author(s): Otani M, Kogo M, Furukawa S, Wakisaka S, Maeda T
  • Journal Title: Cytokine Volume: 58 Issue: 2 Pages: 238-244
  • DOI: 10.1016/j.cyto.2012.01.018
  • Peer Reviewed
• [Presentation] 精巣ライディッヒ細胞におけるC1q/TNF-related protein 3 (CTRP3)の発現とテストステロン産生促進作用
  • Author(s): 應谷昌隆、前田隆史、脇坂 聡、古郷幹彦
  • Organizer: 第67回 日本口腔科学会学術集会
  • Place of Presentation: 栃木・栃木県総合文化センター
• [Presentation] 精巣ライディッヒ細胞におけるC1q/TNF-related protein 3 (CTRP3)の発現とテストステロン産生促進作用
  • Author(s): 應谷昌隆、前田隆史、脇坂 聡、古郷幹彦
  • Organizer: 第114回 大阪大学歯学会
  • Place of Presentation: 大阪・大阪大学弓倉記念ホール
• [Presentation] 血管平滑筋細胞におけるC1q/TNF ファミリー分泌蛋白CTRP3/cartducinのTGF-β1による発現誘導と増殖促進作用
  • Author(s): 前田隆史、脇坂 聡
  • Organizer: 第５３回歯科基礎医学会
  • Place of Presentation: 岐阜・長良川国際会議場