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Reduction system of radiation mucositis on radiotherapy for oral cancer

Research Project

Project/Area Number 23592763
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionOsaka University

Principal Investigator

FURUKAWA Souhei  大阪大学, 歯学研究科(研究院), 教授 (80173524)

Co-Investigator(Kenkyū-buntansha) MURAKAMI Shumei  大阪大学, 歯学研究科, 准教授 (00263301)
KAKIMOTO Naoya  大阪大学, 歯学研究科, 講師 (50324794)
UCHIYAMA Yuka  大阪大学, 歯学研究科, 助教 (80322171)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords放射線治療 / 防護装置 / MRI / 外部照射 / 遮蔽装置 / IMRT / 有害事象 / 副作用 / 頭頸部癌
Research Abstract

The aim of this study was to reduce the radiation mucositis on the radiotherapy for the oral cancers. First of all, we invented a new scoring system using the photo taken with an intra-oral camera and the MR image using IDEAL method.
Then, we invented a new appliance of radiation shield, which was set in the mouth. The materials of the new appliance were the lead (Pb) covered with the plastics. After the impression of the patient teeth, we made a plaster model. Using the plaster model we made the new appliance according to the method of making the denture.
Until now we have applied this new appliance to 12 patients and evaluated the radiation mucositis using the new scoring system above. And, it was suggested that the new appliance could reduce the radiation mucositis.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (29 results)

All 2014 2013 2012 2011 Other

All Journal Article (15 results) (of which Peer Reviewed: 6 results) Presentation (11 results) (of which Invited: 3 results) Book (3 results)

  • [Journal Article] Comparison of the T2 Relaxation Time of the Temporomandibular Joint Articular Disk between Patients with Temporomandibular Disorders and Asymptomatic Volunteers2014

    • Author(s)
      Kakimoto N, Shimamoto H, Chindasombatjaroen J, Tsujimoto T, Tomita S, Hasegawa Y, Murakami S, Furukawa S
    • Journal Title

      AJNR Am J Neuroradiol

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Evaluation of imaging performance of megavoltage cone-beam CT over an extended period2014

    • Author(s)
      Sumida I, Yamaguchi H, Kizaki H, Yamada Y, Koizumi M, Yoshioka Y, Ogawa K, Kakimoto N, Murakami S, Furukawa S
    • Journal Title

      J Radiat Res

      Volume: 55(1) Pages: 191-9

    • Related Report
      2013 Final Research Report
  • [Journal Article] Evaluation of imaging performance of megavoltage cone-beam CT over an extended period2014

    • Author(s)
      Sumida I, Yamaguchi H, Kizaki H, Yamada Y, Koizumi M, Yoshioka Y, Ogawa K, Kakimoto N, Murakami S, Furukawa S.
    • Journal Title

      J Radiat Res.

      Volume: 55 Issue: 1 Pages: 191-9

    • DOI

      10.1093/jrr/rrt100

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temporomandibular joints in patients with rheumatoid arthritis using magnetic resonance imaging2013

    • Author(s)
      Uchiyama Y, Murakami S, Furukawa S
    • Journal Title

      Clin Rheumatol

      Volume: 32(11) Pages: 1613-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] Contrast-enhanced multidetector computerized tomography for odontogenic cysts and cystic-appearing tumors of the jaws : is it useful?2013

    • Author(s)
      Kakimoto N, Chindasombatjaroen J, Tomita S, Shimamoto H, Uchiyama Y, Hasegawa Y, Kishino M, Murakami S, Furukawa S
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol

      Volume: 115(1) Pages: 104-13

    • Related Report
      2013 Final Research Report
  • [Journal Article] CT and MR imaging features of a case of calcifying epithelial odontogenic tumor2012

    • Author(s)
      Uchiyama Y, Murakami S, Kishino M, Furukawa S
    • Journal Title

      JBR-BTR

      Volume: 95(5) Pages: 315-9

    • Related Report
      2013 Final Research Report
  • [Journal Article] Dose reduction trial from 60 Gy in 10 fractions to 54 Gy in 9 fractions schedule in high-dose-rate interstitial brachytherapy for early oral tongue cancer2012

    • Author(s)
      Akiyama H, Yoshida K, Shimizutani K, Yamazaki H, Koizumi M, Yoshioka Y, Kakimoto N, Murakami S, Furukawa S, Ogawa K
    • Journal Title

      J Radiat Res

      Volume: 53(5) Pages: 722-6

    • Related Report
      2013 Final Research Report
  • [Journal Article] Perineural spread of adenoid cystic carcinoma in the oral and maxillofacial regions : evaluation with contrast-enhanced CT and MRI2012

    • Author(s)
      Shimamoto H, Chindasombatjaroen J, Kakimoto N, Kishino M, Murakami S, Furukawa S
    • Journal Title

      Dentomaxillofac Radiol

      Volume: 41(2) Pages: 143-51

    • Related Report
      2013 Final Research Report
  • [Journal Article] Electron beam radiotherapy for tongue cancer using an intra-oral cone2012

    • Author(s)
      Kakimoto N, Murakami S, Nakatani A, Yoshioka Y, Shimizutani K, Furukawa S
    • Journal Title

      Oral Oncol

      Volume: 48(5) Pages: 463-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] Dose reduction trial from 60 Gy in 10 fractions to 54 Gy in 9 fractions schedule in high-dose-rate interstitial brachytherapy for early oral tongue cancer.2012

    • Author(s)
      Akiyama-H, Kakimoto-N (7), Murakami-S (8), Furukawa-S (9)
    • Journal Title

      J Radiat Res

      Volume: 53 Issue: 5 Pages: 722-726

    • DOI

      10.1093/jrr/rrs027

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Electron beam radiotherapy for tongue cancer using an intra-oral cone.2012

    • Author(s)
      Kakimoto-N, Murakami-S, Furukawa (5)
    • Journal Title

      Oral Oncol.

      Volume: 48 Issue: 5 Pages: 463-468

    • DOI

      10.1016/j.oraloncology.2011.12.008

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] CT and MR imaging features of a case of calcifying epithelial odontogenic tumor.2012

    • Author(s)
      Uchiyama-Y, Murakami-S, Kishino-M, Furukawa-S
    • Journal Title

      JBR-BTR

      Volume: 95 Pages: 315-319

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 口腔癌の放射線治療2012

    • Author(s)
      村上秀明
    • Journal Title

      山口県歯報 歯科疾患の最近のTopicー口腔癌治療の最前線ー

      Volume: 56 Pages: 523-526

    • Related Report
      2012 Research-status Report
  • [Journal Article] Effects of cepharanthine with or without Z-100 against leukopenia during radiation therapy for oral cancer2012

    • Author(s)
      Kakimoto-N, Uchiyama-Y (10), Murakami-S (11) , Furukawa (12)
    • Journal Title

      Oral Radiology

      Volume: 28 Pages: 115-120

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correlation between pixel values in a cone-beam computed tomographic scanner and the computed tomographic values in a multidetector row computed tomographic scanner.2011

    • Author(s)
      Chindasombatjaroen J, Kakimoto N, Shimamoto H, Murakami S, Furukawa S.
    • Journal Title

      J Comput Assist Tomogr.

      Volume: 35 Pages: 662-665

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Evaluation of scatter dose from dental materials in head and neck radiation therapy2013

    • Author(s)
      Shimamoto-H, Sumida-I, Marutani-K, Okahata-R, Tsujimoto-T, Tomita-S, Kakimoto-N, Murakami-S, Furukawa-S.
    • Organizer
      2013 ICDMFR, The 19th International Congress of Dento-Maxillo-Facial Radiology
    • Place of Presentation
      Bergen, Norway
    • Related Report
      2013 Annual Research Report
  • [Presentation] Radiation therapy for tongue cancer2013

    • Author(s)
      Murakami-S
    • Organizer
      2013 Chonnam National University Special Seminar
    • Place of Presentation
      Gwangju, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 口腔癌原発巣の画像診断2012

    • Author(s)
      Murakami S, Kakimoto N, Fuchihata H, Kishino M. ほか4件
    • Organizer
      第22回日本歯科医学会総会
    • Place of Presentation
      Radiation therapy for tongue cancer
    • Year and Date
      2012-11-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Usefulness of radiation therapy2012

    • Author(s)
      Murakami S
    • Organizer
      Special symposium at Paris KECO
    • Year and Date
      2012-06-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Usefulness of IDEAL in oral and maxillofacial MR imaging S2012

    • Author(s)
      MURAKAMI, Y. FUJINAMI, N. KAKIMOTO, H. SHIMAMOTO, M. KATAOKA, S. TOMITA, A. NAKATANI, Y. UCHIYAMA, T. SASAI, I. SUMIDA, T. TSUJIMOTO, S. FURUKAWA
    • Organizer
      13th ECDMFR
    • Year and Date
      2012-06-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 口腔癌に対する強度変調放射線治療の初期経験2012

    • Author(s)
      柿本直也、岡畑諒子、丸谷佳右、辻本友美、片岡観精、富田世紀、島本博彰、隅田伊織、中谷温紀、内山百夏、笹井正思、北森秀希、村上秀明、古川惣平
    • Organizer
      第53回日本歯科放射線学会総会・放射線治療懇話会
    • Year and Date
      2012-06-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 口腔癌の頸部転移に対する術後放射線治療の成績2011

    • Author(s)
      片岡観精、辻本友美、中谷温紀、内山百夏、柿本直也 村上秀明、古川惣平
    • Organizer
      日本歯科放射線学会 第31回関西九州合同地方会
    • Place of Presentation
      愛知県
    • Related Report
      2011 Research-status Report
  • [Presentation] 口腔癌に対する強度変調放射線治療の初期経験

    • Author(s)
      柿本直也ら
    • Organizer
      第53回日本歯科放射線学会総会・放射線治療懇話会
    • Place of Presentation
      盛岡
    • Related Report
      2012 Research-status Report
  • [Presentation] Usefulness of radiation

    • Author(s)
      Murakami-S
    • Organizer
      Special symposium at Paris KECO
    • Place of Presentation
      Paris, France
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] RESULTS OF THE POSTOPERATIVE RADIOTHERAPY FOR NECK NODE METASTASIS IN ORAL CANCER

    • Author(s)
      Kataoka-M, Uchiyama-Y (5), et al.
    • Organizer
      13th ECDMFR
    • Place of Presentation
      Leipzig, Germany
    • Related Report
      2012 Research-status Report
  • [Presentation] 口腔癌の放射線治療

    • Author(s)
      村上秀明
    • Organizer
      山口県口腔癌研究会
    • Place of Presentation
      山口
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] お口の健康全身元気ー各世代の最新歯科医療ー2013

    • Author(s)
      村上秀明
    • Related Report
      2013 Final Research Report
  • [Book] お口の健康 全身元気 ー各世代の最新歯科医療ー2013

    • Author(s)
      村上秀明(共著)
    • Total Pages
      343
    • Publisher
      医歯薬出版
    • Related Report
      2013 Annual Research Report
  • [Book] 口腔癌とリンパ節の画像診断

    • Author(s)
      村上秀明
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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