Exit of intracellular Porphyromonas gingivalis from gingival epithelial cells is associated with chronic periodontal desease
| Project/Area Number |
23592764
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AKIYAMA Shigehisa 大阪大学, 歯学部附属病院, 准教授 (00283797)
MURAKAMI Jumpei 大阪大学, 歯学部附属病院, 助教 (70362689)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | Porphyromonas gingivalis / エンドサイトーシス / オートファジー / 歯周病 / P.gingivalis / porphyromonas gingivalis |
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| Research Abstract |
Porphyromonas gingivalis has been reported to be a main factor for periodontitis. P. gingivalis enters cells by the endocytosis and damages to various cell functions. Nevertheless, intracellular traffic of P. gingivalis is largely unknown .Recently, We found that P. gingivalis utilizes endocytic recycling pathway for their survival from intracellular mechanism of killing bactria, and the organisms exit from infected cells and re-enter neighbouring cells, which may cause persistant infection.
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Report
(4 results)
Research Products
(34 results)
