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Establishment of saliva metabolome analysis using mice experimental cancer model

Research Project

Project/Area Number 23592784
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionTsurumi University

Principal Investigator

SHIBATA Tatsuya  鶴見大学, 歯学部, 助教 (90323708)

Co-Investigator(Kenkyū-buntansha) SHIMADA Akemi  鶴見大学, 歯学部, 助教 (00339813)
NAKASHIMA Kazuhisa  鶴見大学, 歯学部, 非常勤講師 (90252692)
SUGIMOTO Masahiro  慶應義塾大学, 政策メディア研究科, 准教 (30458963)
NIFUJI Akira  鶴見大学, 歯学部, 教授 (00240747)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsメタボローム / 唾液 / 腫瘍 / 癌 / 唾液メタボローム
Research Abstract

Saliva contains components originating from blood but it is only applicated to diagnosis in specific diseases. Metabolome analysis aims to comprehensively identify and quantify metabolites in bodily fluids. To diagnose diseases with the salivary metabolome analysis, it should be clear whether or not there is the metabolome profile difference between saliva and blood, and whether or not a disease affects the metabolome profile.
In this study, we compared the metabolome profiles of saliva and blood in mice and many metabolites were consistently detected in both saliva and blood, indicating that metabolites in blood transfer to saliva. Based on this result, we are analyzing the salivary metabolome profile in experimental mice cancer model.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (21 results)

All 2013 2012

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (5 results)

  • [Journal Article] CE-MS–based metabolome analysis of serum and saliva from neurodegenerative dementia patients2013

    • Author(s)
      Tsuruoka M., Hara J., Hirayama A., Sugimoto M., Soga T., Shankle W.R., Tomita M.
    • Journal Title

      Electrophoresis

      Volume: 34 Issue: 19 Pages: 2865-2872

    • DOI

      10.1002/elps.201300019

    • Year and Date
      2013-09-06
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alendronate promotes bone formation by inhibiting protein prenylation in osteoblasts in rat tooth replantation model2013

    • Author(s)
      Komatsu K, Shimada A, Shibata T, Wada S, Ideno H, Nakashima K, Amizuka N, Noda M, Nifuji A.
    • Journal Title

      Journal of Endocrinology

      Volume: 219 Issue: 2 Pages: 145-158

    • DOI

      10.1530/joe-13-0040

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells2013

    • Author(s)
      Ryoko Araki
    • Journal Title

      Nature

      Volume: 494 Issue: 7435 Pages: 100-104

    • DOI

      10.1038/nature11807

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms of skeletal tissue formation2013

    • Author(s)
      Nifuji A
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 2 Pages: 1-8

    • NAID

      10031159011

    • URL

      http://www.jspfsm.umin.ne.jp/journal/

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Predominant expression of H3K9 methyltransferases in prehypertrophic and hypertrophic chondrocytes during mouse growth plate cartilage development2013

    • Author(s)
      Ideno H, Shimada A, Imaizumi K, Kimura H, Abe M, Nakashima K, and Nifuji A
    • Journal Title

      Gene Expr Pat

      Volume: 13 Issue: 3-4 Pages: 84-90

    • DOI

      10.1016/j.gep.2013.01.002

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metabolome analysis of erythrocytes from patients with chronic hepatitis C reveals the etiology of ribavirin-induced hemolysis2013

    • Author(s)
      Karasawa, T., Saito, T., Ueno, Y., Sugimoto, M., Soga, T.
    • Journal Title

      Int J Med Sci.

      Volume: 10 Issue: 11 Pages: 1575-1577

    • DOI

      10.7150/ijms.6436

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamics of serum metabolites in patients with chronic hepatitis C receiving pegylated interferon plus ribavirin: A metabolomics analysis2013

    • Author(s)
      Saito, T., Sugimoto, M., Igarashi, K., Saito, K., Shao, L., Katsumi, T., Tomita, K., Sato, C., Ishii, R., Okumoto, K., Nishise, Y., Watanabe, H., Tomita, M., Ueno, Y., Soga, T.
    • Journal Title

      Metabolism

      Volume: 62 Issue: 11 Pages: 1577-1586

    • DOI

      10.1016/j.metabol.2013.07.002

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-Resolution-Imaging Mass Spectrometry Reveals Detailed Spatial Distribution of Phosphatidylinositols in Human Breast Cancer2013

    • Author(s)
      Kawashima M., Iwamoto N., Kawaguchi-Sakita, N., Sugimoto M., Ueno T., Mikami Y. Terasawa K., Sato, T., Tanaka K., Shimizu K., Toi M.
    • Journal Title

      Cancer Science

      Volume: 104 Pages: 1372-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes of Metabolic Profiles in an Oral Squamous Cell Carcinoma Cell Line Induced by Eugenol2013

    • Author(s)
      Koh T., Murakami Y., Machino M., Onuma H., Kaneko M., Sugimoto M., Soga T., Tomita M.
    • Journal Title

      In Vivo

      Volume: 27 Pages: 233-243

    • URL

      http://iv.iiarjournals.org/content/27/2/233.full.pdf+html

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-resolution imaging mass spectrometry reveals detailed spatial distribution of phosphatidylinositols in human breast cancer2013

    • Author(s)
      Kawashima M., Iwamoto N., Kawaguchi-Sakita, N., Sugimoto M., Ueno T., Mikami Y. Terasawa K., Sato, T., Tanaka K., Shimizu K., Toi M.
    • Journal Title

      Cancer Science

      Volume: 104 Issue: 10 Pages: 1372-1379

    • DOI

      10.1111/cas.12229

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improved methods for detection of ss-galactosidase (lacZ) activity in hard tissue2012

    • Author(s)
      Shimada A, Komatsu K, Nakashima K, Poschl E, Nifuji A
    • Journal Title

      Histochemistry and Cell Biology

      Volume: 137 Issue: 6 Pages: 841-847

    • DOI

      10.1007/s00418-012-0936-1

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pilot study of changes in salivary metabolic profiles induced by template therapy2012

    • Author(s)
      Tanaka S., Taga H., Maehara K., Kaneshima A., Machino M., Onuma H., Kaneko M., Sakagami H.
    • Journal Title

      In Vivo

      Volume: 26(6) Pages: 1015-20

    • URL

      http://iv.iiarjournals.org/content/26/6/1015.long

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metabolic profiling reveals new serum biomarkers for differentiating diabetic nephropathy2012

    • Author(s)
      Hirayama A., Nakashima E., Sugimoto M., Akiyama S., Sato W., Maruyama S., Matsuo S., Tomita M., Yuzawa Y., Soga T.
    • Journal Title

      Analytical and Bioanalytical Chemistry

      Volume: 404(10) Pages: 3101-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human blood metabolite timetable indicates internal body time2012

    • Author(s)
      Kasukawa T, Sugimoto M, Hida A, Minami Y, Mori M, Honma S, Honma K, Mishima K, Soga T, Ueda HR
    • Journal Title

      Proc.Natl. Acad. Sci. U.S.A

      Volume: 109(37) Issue: 37 Pages: 15036-41

    • DOI

      10.1073/pnas.1207768109

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bioinformatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis2012

    • Author(s)
      Sugimoto M., Kawakami M., Robert M., Soga T., Tomita M.
    • Journal Title

      Current Bioinformatics

      Volume: 7(1) Pages: 96-106

    • URL

      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299976/

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Predictions of the pathological response to neoadjuvant chemotherapy in patients with primary breast cancer using a data mining technique2012

    • Author(s)
      Takada M., Sugimoto M., Ohno S., Kuroi K., Sato N., Bando H., Masuda N., Iwata H., Kondo M., Sasano H., Chow L.W.C., Inamoto T., Naito Y., Tomita M., and Toi M.
    • Journal Title

      Breast Cancer Research and Treatment

      Volume: 134 Issue: 2 Pages: 661-70

    • DOI

      10.1007/s10549-012-2109-2

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 代謝産物の血液から唾液への移行についての検討2013

    • Author(s)
      柴田達也、杉本昌弘、金子未来、島田明美、小松浩一郎、出野尚、中島和久、冨田勝、二藤彰
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] Endocytic incorporation of alendronate promotes bone formation2013

    • Author(s)
      Komatsu K, Shimada A, Ideno H, Shibata T, Nakashima K, Amizuka N, Noda M, Nifuji A
    • Organizer
      2nd Joint Meeting of the International Bone and Mineral Society and the Japanese Society for Bone and Mineral Research
    • Place of Presentation
      Kobe Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] 代謝産物の血液から唾液への移行についての検討2013

    • Author(s)
      柴田達也、杉本昌弘、金子未来、島田明美、小松浩一郎、出野 尚、中島和久、冨田 勝、二藤 彰
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Endocytic incorporation of alendronate promotes bone formation.2013

    • Author(s)
      Komatsu K, Shimada A, Ideno H, Shibata T, Nakashima K, Amizuka N, Noda M, Nifuji A.
    • Organizer
      国際骨代謝学会(IBMS)・日本骨代謝学会(JSBMR)第2回合同国際会議
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] アレンドロネートの細胞内取込みによる骨形成の促進2012

    • Author(s)
      小松浩一郎、島田明美、出野尚、柴田達也、中島和久、二藤彰
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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