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Quantitative elucidation of change in fluorine associated with caries progression and inhibition

Research Project

Project/Area Number 23592796
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionOsaka University

Principal Investigator

YAMAMOTO Hiroko  大阪大学, 歯学研究科(研究院), 招へい教員 (60448107)

Co-Investigator(Kenkyū-buntansha) IWAMI Yukiteru  大阪大学, 大学院歯学研究科, 助教 (90303982)
Co-Investigator(Renkei-kenkyūsha) YASUDA Keisuke  若狭湾エネルギー研究センター, 主任研究員 (00359241)
OKUYAMA Katsushi  北海道大学, 大学院歯学研究科, 助教 (00322818)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsフッ素 / 定量測定法 / う蝕 / 加速器 / PIXE/PIGE / PIXE/PIGE / 定量測定 / 脱灰 / 再石灰化 / PIGE / フッ素定量測定法 / フッ素徐放性歯科材料 / 歯質
Research Abstract

We have developed a new fluorine quantitative measurement method using a micro-PIXE (Proton Induced X-ray Emission) / PIGE (Proton Induced Gamma-ray Emission). By using this measurement method, it has become possible for the first time to catch the movement of fluorine upon demineralization of tooth. Further, it was shown that the fluorine in the tooth released with decalcified was again taken into the tooth.
The possibility that concentration value of fluorine in the tooth measured conventionally was contained both those not attached to the tooth, such as CaF2, and those attached to the tooth, has been shown.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (38 results)

All 2013 2012 2011 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (23 results)

  • [Journal Article] Validity of a portable microhardness testing system (Cariotester) for diagnosis of progression in active caries lesions2013

    • Author(s)
      Iwami Y, Yamamoto H, Hayashi M.
    • Journal Title

      Dent Mater J

      Volume: 32(4) Pages: 667-672

    • NAID

      10031178653

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Validity of a portable microhardness testing system (Cariotester) for diagnosis of progression in active caries lesions2013

    • Author(s)
      Iwami Y, Yamamoto H, Hayashi M
    • Journal Title

      Dent Mater

      Volume: 324 Pages: 667-672

    • NAID

      10031178653

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 修復処置におけるう蝕象牙質除去の客観性についての臨床的評価2013

    • Author(s)
      伊藤祥作,岩見行晃,山本洋子ほか
    • Journal Title

      日歯保存誌

      Volume: 56 Pages: 441-453

    • NAID

      110009830602

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Two Fluoride Regimens on Fluorine Uptake in Carious Enamel during pH-cycling2012

    • Author(s)
      H. Komatsu , Y. Matsuda , S. Ooki , N. Hasimoto , K. Okuyama , H. Yamamoto , Y. Iwami , S. Ebisu , M. Nomachi , K. Yasuda , T. Satoh and M. Kohka
    • Journal Title

      JAEA Takasaki Annual Report 2011 JAEA-Review

      Volume: 2012-046 Pages: 82-82

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of fluorine distribution in carious enamel around 1.5-year aged fluoride-containing materials2012

    • Author(s)
      H. Komatsu et al
    • Journal Title

      JAEA Takasaki Annual Report 2010 JAEA-Review

      Volume: 2011-043 Pages: 85-85

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Measurement of fluorine distribution in carious enamel around 1.5-year aged fluoride-containing materials2011

    • Author(s)
      H. Komatsu, K. Kojima, Y. Funato, Y. Matsuda, T. Kijimura, K. Okuyama, H. Yamamoto, Y. Iwami, S. Ebisu, M. Nomachi, K. Yasuda, T. Satoh, M. Koka
    • Journal Title

      JAEA Takasaki Annual Report 2010 JAEA-Review

      Volume: 2011-043 Pages: 85-85

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Progress of in-air microbeam system at the Wakasa Wan Energy Research Center2011

    • Author(s)
      K.Yasuda, M. Nomachi, Y. Sugaya, H. Yamamoto, H. Komatsu
    • Journal Title

      Nuclear Instruments & Methods in Physics Research Section B

      Volume: 269 Pages: 2180-2183

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fluoride uptake into human teeth from a fluoride-releasing a thin layer after a long period of filling2011

    • Author(s)
      Yamamoto H, Iwami Y, Ebisu S, Komatsu H, Nomachi M, Sugaya Y, Yasuda K.
    • Journal Title

      IJPIXE

      Volume: (21) Pages: 31-38

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fluorine analysis of human enamel around fluoride-containing materials under different pH-cycling by l-PIGE/PIXE system2011

    • Author(s)
      Komatsu H, Yamamoto H, Matsuda M, Kijimura T, Kinugawa M. Okuyama K, Nomachi M, Yasuda K, Satoh T, Oikawa S.
    • Journal Title

      Nucl Instr and Meth

      Volume: B269 Pages: 2274-2277

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fluorine analysis of human dentin surrounding resin composite after fluoride application by l-PIGE/PIXE analysis2011

    • Author(s)
      Okuyama K, Komatsu H, Yamamoto H, Pereira P.N.R, Bedran-Russo A.K, Nomachi M, Sato T, Sano H.
    • Journal Title

      Nucl Instr and Meth

      Volume: B269 Pages: 2269-2273

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between laser fluorescence and bacterial invasion in arrested carious lesions2011

    • Author(s)
      Iwami Y, Yamamoto H, Hayashi M, Ebisu S.
    • Journal Title

      Lasers Med Sci

      Volume: 26(4) Pages: 439-444

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fluoride uptake in human teeth from a fluoride-releasing thin layer after a long period of filling2011

    • Author(s)
      H. Yamamoto et al
    • Journal Title

      International Journal of PIXE

      Volume: 21 Pages: 31-38

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fluorine analysis of human dentin surrounding resin composite after fluoride application by μ-PIGE/PIXE analysis2011

    • Author(s)
      K. Okuyama et al
    • Journal Title

      Nuclear Instruments & Methods in Physics Research B

      Volume: 269 Pages: 2269-2273

    • NAID

      120003596806

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fluorine analysis of human enamel around fluoride-containing materials under different pH-cycling by μ-PIGE/PIXE system2011

    • Author(s)
      H. Komatsu et al
    • Journal Title

      Nuclear Instruments and Methods in Physics Research B

      Volume: 269 Pages: 2274-2277

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Progress of in-air microbeam system at the Wakasa Wan Energy Research Center2011

    • Author(s)
      K.Yasuda et al
    • Journal Title

      Nuclear Instruments & Methods in Physics Research B

      Volume: 269

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] フッ素含有歯科材料からのフッ素と歯質との結合状態2013

    • Author(s)
      小松久憲、奥山克史、山本洋子、安田啓介、能町正治, 菅谷頼仁
    • Organizer
      第29回PIXEシンポジウム
    • Place of Presentation
      敦賀
    • Year and Date
      2013-11-15
    • Related Report
      2013 Final Research Report
  • [Presentation] フッ化物含有歯面塗布剤適用後の歯根面におけるフッ素濃度分布2013

    • Author(s)
      奥山克史、小松久憲、大木彩子、橋本直樹、松田康裕、佐野英彦、山本洋子、林美加子、能町正治、菅谷頼仁、安田啓介、佐藤隆博、江夏昌志
    • Organizer
      第8回高崎量子応用研究シンポジウム-高崎量子応用研究所50周年を迎えて-
    • Place of Presentation
      高崎シティギャラリー
    • Year and Date
      2013-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Comparison of fluoride regimens on fluorine uptake in carious enamel2013

    • Author(s)
      Hashimoto N, Funato Y, Oki S, Matsuda Y, Okuyama K, Yamamoto H, Komatsu H, Sano H.
    • Organizer
      91h IADR総会
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2013-03-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Demineralize prevention of dentin with fluoride varnish via automatic pH-cycling2013

    • Author(s)
      Oki S, Matsuda Y, Hashimoto N, Okuyama K, Yamamoto H, Funato Y, Komatsu H, Sano H.
    • Organizer
      91h IADR総会
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2013-03-20
    • Related Report
      2013 Final Research Report
  • [Presentation] フッ化物含有材料から歯質へのフッ化物取り込みの経時的変化2012

    • Author(s)
      奥山克史、小松久憲、山本洋子、安田啓介、船戸良基、木地村太基、佐野英彦
    • Organizer
      第137回日本歯科保存学会秋季学術大会
    • Place of Presentation
      広島
    • Year and Date
      2012-11-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 核反応による歯質内のフッ素分布測定(XI)2012

    • Author(s)
      小松久憲、松田康裕、大木彩子、橋本直樹、奥山克史、山本洋子、能町正治、菅谷頼仁、安田啓介、佐藤隆博、江夏昌志
    • Organizer
      第7回高崎量子応用研究シンポジウム
    • Place of Presentation
      高崎
    • Year and Date
      2012-10-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Strontium Analysis of Carious Human Tooth around a Foluoride-containing Material using byμ-PIGE/PIXE System2012

    • Author(s)
      Komatsu H, Funato Y, Matsuda Y, Kijimura T, Okuyama K, Yamamoto H, Nomachi M, Yasuda K, Satoh T and Kohka M.
    • Organizer
      13th ICNMTA
    • Place of Presentation
      Lisbon, Portugal
    • Year and Date
      2012-07-24
    • Related Report
      2013 Final Research Report
  • [Presentation] Fluoride concentration change in a tooth with acid treatment2012

    • Author(s)
      Yamamoto H, Iwami Y, Komatsu H,Nomachi M, Sugaya Y, and Yasuda K.
    • Organizer
      13th ICNMTA
    • Place of Presentation
      Lisbon, Portugal
    • Year and Date
      2012-07-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Fluorine-analysis of Cavity Walls in Glass-ionomer Restorations using PIGE/PIXE System2012

    • Author(s)
      H. Komatsu, K. Okuyama, T. Kijimura, H. Yamamato, Y. Iwami, K. Yasuda, M. Nomachi4 and Y. Sugaya
    • Organizer
      90h IADR総会
    • Place of Presentation
      Iguaçu Falls, Brazil
    • Year and Date
      2012-06-21
    • Related Report
      2013 Final Research Report
  • [Presentation] フッ素含有材料周囲齲蝕エナメル質におけるストロンチウム分布の測定2011

    • Author(s)
      船戸良基、小松久憲、小島健太郎、松田康裕、奥山克史、木地村太基、佐野英彦、山本洋子
    • Organizer
      第135回日本歯科保存学会秋季学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 核反応による歯質内のフッ素分布測定(x)2011

    • Author(s)
      小松久憲、小島健太郎、船戸良基、松田康裕、奥山克史、山本洋子、能町正治、菅谷頼仁、安田啓介、佐藤隆博、江夏昌志
    • Organizer
      第6回高崎量子応用研究シンポジウム
    • Place of Presentation
      高崎
    • Year and Date
      2011-10-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 核反応による歯質内のフッ素分布測定(X)2011

    • Author(s)
      小松久憲  ら
    • Organizer
      第6回高崎量子応用研究シンポジウム
    • Place of Presentation
      高崎
    • Related Report
      2011 Research-status Report
  • [Presentation] フッ素含有材料周囲う蝕エナメル質におけるストロンチウム分布の測定2011

    • Author(s)
      船戸良基 ら
    • Organizer
      日本歯科保存学会2011年度秋期学術大会(第135回)
    • Place of Presentation
      大阪
    • Related Report
      2011 Research-status Report
  • [Presentation] フッ化物含有歯面塗布剤適用後の歯根面におけるフッ素濃度分布

    • Author(s)
      奥山克史、小松久憲、大木彩子、橋本直樹、松田康裕、佐野英彦、山本洋子、林美加子、能町正治、菅谷頼仁、安田啓介、佐藤隆博、江夏昌志
    • Organizer
      第8回高崎量子応用研究シンポジウム
    • Place of Presentation
      高崎市
    • Related Report
      2013 Annual Research Report
  • [Presentation] フッ素含有歯科材料からのフッ素と歯質との結合状態

    • Author(s)
      小松久憲、奥山克史、山本洋子、安田啓介、能町正治,菅谷頼仁
    • Organizer
      第29回PIXEシンポジウム
    • Place of Presentation
      敦賀市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Fluorine-analysis of Cavity Walls in Glass-ionomer Restorations using PIGE/PIXE System,

    • Author(s)
      H. Komatsu et al
    • Organizer
      90h IADR総会
    • Place of Presentation
      Iguacu Falls, Brazil,
    • Related Report
      2012 Research-status Report
  • [Presentation] Fluoride Concentration Change in a Tooth with Acid Treatment

    • Author(s)
      H.Yamamoto et al
    • Organizer
      13th ICNMTA
    • Place of Presentation
      Lisbon, Portugal
    • Related Report
      2012 Research-status Report
  • [Presentation] Strontium Analysis of Carious Human Tooth around a Foluoride-containing Material using by μ-PIGE/PIXE System:

    • Author(s)
      H. Komatsu et al
    • Organizer
      13th ICNMTA
    • Place of Presentation
      Lisbon, Portugal
    • Related Report
      2012 Research-status Report
  • [Presentation] 核反応による歯質内のフッ素分布測定(XI)

    • Author(s)
      小松久憲 ら
    • Organizer
      第7回高崎量子応用研究シンポジウム
    • Place of Presentation
      高崎
    • Related Report
      2012 Research-status Report
  • [Presentation] 慢性う蝕の進行状態の評価におけるう蝕歯質の硬さ測定の有用性

    • Author(s)
      岩見行晃 ら
    • Organizer
      第137回日本歯科保存学会秋季学術大会
    • Place of Presentation
      広島
    • Related Report
      2012 Research-status Report
  • [Presentation] フッ化物含有材料から歯質へのフッ化物取り込みの経時的変化

    • Author(s)
      奥山克史 ら
    • Organizer
      第137回日本歯科保存学会秋季学術大会
    • Place of Presentation
      広島
    • Related Report
      2012 Research-status Report
  • [Presentation] Demineralize Prevention of Dentin with Fluoride Varnish via Automatic pH-cycling

    • Author(s)
      S.Oki et al
    • Organizer
      91h IADR総会
    • Place of Presentation
      Seattle, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Demineralize Prevention of Dentin with Fluoride Varnish via Automatic pH-cycling

    • Author(s)
      N.Hashimoto et al
    • Organizer
      91h IADR総会
    • Place of Presentation
      Seattle, USA
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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