| Project/Area Number |
23592806
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKAGAMI Hiroshi 明海大学, 歯学部, 教授 (50138484)
UMEMURA Naoki 明海大学, 歯学部, 助教 (80609107)
ISHIHARA Sachiyo 明海大学, 歯学部, 講師 (10223017)
岩坂 憲助 明海大学, 歯学部, 講師 (60424058)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 再生医学 / 歯学 / 生体材料 / 歯髄 / 幹細胞 / 歯髄幹細胞 / 硬組織再生 / 多血小板血漿 |
|---|
| Research Abstract |
In general, undifferentiated mesenchymal cells are in abundant supply in human dental pulp tissue, and it is known that containing a large number of stem cells. However, the clarification of characteristics of dental pulp stem cells (DPSCs) and differentiation signaling are still unknown. Therefore, We determined expression of CD44 that is known as a stem cell surface marker upon human DPSCs. The CD44 expression was approximately 60%. Then, hyaluronic acid that is a ligand of CD44 treatment induced expression of alkaline phosphatase. These data suggested that CD44 signaling may induce efficient calcification on DPSCs.
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