Development of the multipurpose adhesive system using Drug Delivery for Improved Direct pulp capping, Pulpotomy, and Periodontal treatment

• Project/Area Number: 23592822
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Kibi International University Junior College
• Principal Investigator: NAKAMURA Mariko 吉備国際大学短期大学部, 保健科, 教授 (90284067)
• Co-Investigator(Kenkyū-buntansha): YOSHIDA Yasuhiro 北海道大学, 大学院歯学研究科, 教授 (90281162) ; MATSUKAWA Akihiro 岡山大学, 大学院医歯(薬)学総合研究科, 教授 (90264283)
• Co-Investigator(Renkei-kenkyūsha): ITO Yoshihiro 独立行政法人理化学研究所, 伊藤ナノ医工学研究室 (40192497)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: リン酸化プルラン / 可視光硬化型ゼラチン

Research Abstract

The purpose of this study is to develop a multi-purpose bio-adhesive system by the visible light-induced crosslinkable geratin and phosphorylated pullulan. The following things were confirmed from these findings. Phosphorylated pullulan-based composite is adhesive to dentin and possesses high biocompatibility. The visible light-induced crosslinkable gelatin is adhesive to dentin and low cellular toxicity. It was suggested that the visible light-induced crosslinkable gelatin and phosphorylated pullulan can be used as key materials of biodegradable adhesives for regeneration and reconstruction of bone and tooth.

Research Products

• [Journal Article] Mussel-inspired human gelatin nanocoating for creating biologically adhesive surfaces (2014)
  • Author(s): Yang, X., Zhu, L., Tada, S., Zhou, D., Kitajima, T., Isoshima, T., Yoshida, Y., Nakamura, M., Yan, W., Ito, Y
  • Journal Title: International Journal Nanomedicine Volume: 29 Pages: 2753-2765
  • DOI: 10.2147/ijn.s60624
  • Peer Reviewed
• [Journal Article] A novel, visible light-induced, rapidly cross-linkable gelatin scaffold for osteochondral tissue engineering (2014)
  • Author(s): Tetsuro Mazaki, Yasuyuki Shiozaki, Kentaro Yamane, Aki Yoshida, Mariko Nakamura, Yasuhiro Yoshida, Di Zhou, Takashi Kitajima, Masato Tanaka, Yoshihiro ito, Toshifumi Ozaki, and Akihiro Matsukawa
  • Journal Title: Sci. Rep. Volume: 4 Issue: 1 Pages: 4457-4457
  • DOI: 10.1038/srep04457
  • NAID: 120005526619
  • Peer Reviewed
• [Journal Article] A novel, visible light-induced, rapidly cross-linkable gelarin scaffold for osteochondral tissue engineering (2014)
  • Author(s): Mazaki, T., Shiozaki, Y., Yamane, K., Yoshida, A., Nakamura, M., Yoshida, Y., Zhou, D., Kitajima, T., Tanaka, M., Ito, Y., Ozaki, T., Matsukawa, A.
  • Journal Title: Scientific Reports Volume: 4
  • Peer Reviewed
• [Journal Article] Enhanced in vivo osteogenesis by nanocarrier-fused BMP4 (2013)
  • Author(s): Y. Shiozaki
  • Journal Title: Int. J. Nanomed. Volume: 8 Pages: 1349-1360
  • DOI: 10.2147/ijn.s44124
  • Peer Reviewed
• [Presentation] 家兎骨軟骨欠損モデルにおける可視光硬化ゼラチンおよび骨髄間質細胞の組織修復効果 (2013)
  • Author(s): 香川洋平、馬崎哲朗、塩崎泰之、山根健太郎、吉田晶、松川昭博、中村真理子、吉田靖弘、北嶋隆、伊藤嘉浩、尾崎敏文
  • Organizer: 第28回日本整形外科学会基礎学術集会
  • Place of Presentation: 千葉
• [Presentation] 可視光硬化ゼラチンとcollagen binding domain(CBD)-BMP4の併用による家兎骨軟骨組織修復効果 (2013)
  • Author(s): 馬崎哲朗、塩崎泰之、山根健太郎、香川洋平、篠原健介、吉田晶、松川昭博、中村真理子、吉田靖弘、北嶋隆、伊藤嘉浩、尾崎敏文
  • Organizer: 第28回日本整形外科学会基礎学術集会
  • Place of Presentation: 千葉
• [Presentation] 可視光硬化ゼラチンとcollagen binding domain(CBD)-BMP4の併用による家兎骨軟骨組織修復効果 (2013)
  • Author(s): 馬崎哲朗，塩崎泰之，山根健太郎，香川洋平，篠原健介，吉田晶，松川昭博，中村真理子，吉田靖弘，北嶋隆，伊藤嘉浩，尾崎敏文
  • Organizer: 第28回日本整形外科学会基礎学術集会
  • Place of Presentation: 幕張メッセ国際会議場，東京ベイホテル
• [Presentation] 家兎軟骨欠損モデルにおける可視光硬化ゼラチンおよび骨髄間質細胞の組織修復能 (2013)
  • Author(s): 香川洋平，馬崎哲朗，塩崎泰之，山根健太郎，吉田晶，松川昭博，中村真理子，吉田靖弘，北嶋隆，伊藤嘉浩，尾崎敏文
  • Organizer: 第２８回日本整形外科学会基礎学術集会
  • Place of Presentation: 幕張メッセ国際会議場，東京ベイホテル
• [Presentation] コラーゲン結合性骨形成蛋白質BMP4の骨芽細胞に対する影響 (2012)
  • Author(s): 吉田晶、古松毅之、塩崎泰之、馬崎哲朗、松川昭博、中村真理子、吉田靖弘、北嶋隆、伊藤嘉浩、尾崎敏文
  • Organizer: 第48回日本移植学会総会
  • Place of Presentation: 名古屋
• [Presentation] マウスを用いた遺伝子改変成長因子Collagen binding domain BMP4の効果 (2012)
  • Author(s): 塩崎泰之、馬崎哲朗、山根健太郎、吉田靖弘、中村真理子、北嶋隆、伊藤嘉浩、尾崎敏文、松川昭博
  • Organizer: 第34回日本バイオマテリアル学会大会
  • Place of Presentation: 仙台
• [Presentation] ウサギの骨欠損モデルにおいてコラーゲン結合性骨形成蛋白質は骨形成を促進する (2012)
  • Author(s): 吉田晶、塩崎泰之、馬崎哲朗、古松毅之、松川昭博、中村真理子、吉田靖弘、北嶋隆、伊藤嘉浩、尾崎敏文
  • Organizer: 第34回日本バイオマテリアル学会大会
  • Place of Presentation: 仙台
• [Presentation] 家兎骨軟骨欠損モデルにおける可視硬化ゼラチンの骨軟骨組織修復の効果 (2012)
  • Author(s): 馬崎哲朗、塩崎泰之、吉田晶、松川昭博、中村真理子、吉田靖弘、北嶋隆、伊藤嘉浩、尾崎敏文
  • Organizer: 第34回日本バイオマテリアル学会大会
  • Place of Presentation: 仙台
• [Presentation] コラーゲン結合型BMP4の骨芽細胞に対する影響 (2012)
  • Author(s): 吉田晶、馬崎哲朗、塩崎泰之、古松毅之、松川昭博、中村真理子、吉田靖弘、北嶋隆、伊藤嘉浩、尾崎敏文
  • Organizer: 第27回日本整形外科学会基礎学術集会
  • Place of Presentation: 名古屋
• [Presentation] ウサギの骨欠損モデルにおけるコラーゲン結合性骨形成蛋白質の有効性 (2012)
  • Author(s): 馬崎哲朗、塩崎泰之、吉田晶、松川昭博、中村真理子、吉田靖弘、北嶋隆、伊藤嘉浩、尾崎敏文
  • Organizer: 第27回日本整形外科学会基礎学術集会
  • Place of Presentation: 名古屋
• [Presentation] Phosphorylated pullulan bioadhesive for regeneration and reconstruction of bone and tooth (2012)
  • Author(s): Yoshida, Y., Okihara, T., Nakamura, M., Matsumoto, T.
  • Organizer: Bioceramics-24
  • Place of Presentation: Fukuoka
• [Presentation] Visible Light-Induced Crosslinkable Gelatin for Direct Pulp Capping (2012)
  • Author(s): Nakamura, M., Yoshida, Y., Ito, Y.
  • Organizer: Bioceramics-24
  • Place of Presentation: Fukuoka
• [Presentation] Phosphorylated pullulan bioadhesive for regeneration and reconstruction of bone and tooth (2012)
  • Author(s): Yasuhiro Yoshida , Takumi Okihara , Mariko Nakamura, Takuya Matsumoto
  • Organizer: Bioceramics24
  • Place of Presentation: Fukuoka
• [Presentation] Visible Light-Induced Crosslinkable Gelatin for Direct Pulp Capping (2012)
  • Author(s): Mariko Nakamura, Yasuhiro Yoshida, Yoshihiro Ito
  • Organizer: Bioceramics24
  • Place of Presentation: Fukuoka
• [Book] Visible Light-Induced Crosslinkable Gelatin for Direct Pulp Capping (2013)
  • Author(s): Nakamura, M., Yoshida, Y., Ito, Y.
  • Publisher: Key Engineering Materials
• [Book] Phosphorylated pullulan bioadhesive for regeneration and reconstruction of bone and tooth (2013)
  • Author(s): Yoshida, Y., Okihara, T., Nakamura, M., Matsumoto, T.
  • Publisher: Key Engineering Materials
• [Patent(Industrial Property Rights)] 生体硬組織接着用キット (2013)
  • Inventor(s): 吉田靖弘, 田中雅人, 鈴木一臣, 尾崎敏文, 高畑智宏, 入江正郎, 中村真理子, 河島光伸, 野尻大和, 岡田浩一, 長尾昌浩
  • Industrial Property Rights Holder: 国立大学法人岡山大学, 学校法人順正学園
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-01-11
• [Patent(Industrial Property Rights)] 生体埋込型医療機器被覆用組成物 (2012)
  • Inventor(s): 吉田靖弘ほか
  • Industrial Property Rights Holder: 吉田靖弘ほか
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-203876
  • Filing Date: 2012-09-15