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Development of the multipurpose adhesive system using Drug Delivery for Improved Direct pulp capping, Pulpotomy, and Periodontal treatment

Research Project

Project/Area Number 23592822
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionKibi International University Junior College

Principal Investigator

NAKAMURA Mariko  吉備国際大学短期大学部, 保健科, 教授 (90284067)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Yasuhiro  北海道大学, 大学院歯学研究科, 教授 (90281162)
MATSUKAWA Akihiro  岡山大学, 大学院医歯(薬)学総合研究科, 教授 (90264283)
Co-Investigator(Renkei-kenkyūsha) ITO Yoshihiro  独立行政法人理化学研究所, 伊藤ナノ医工学研究室 (40192497)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsリン酸化プルラン / 可視光硬化型ゼラチン
Research Abstract

The purpose of this study is to develop a multi-purpose bio-adhesive system by the visible light-induced crosslinkable geratin and phosphorylated pullulan. The following things were confirmed from these findings. Phosphorylated pullulan-based composite is adhesive to dentin and possesses high biocompatibility. The visible light-induced crosslinkable gelatin is adhesive to dentin and low cellular toxicity. It was suggested that the visible light-induced crosslinkable gelatin and phosphorylated pullulan can be used as key materials of biodegradable adhesives for regeneration and reconstruction of bone and tooth.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (22 results)

All 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (14 results) Book (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Mussel-inspired human gelatin nanocoating for creating biologically adhesive surfaces2014

    • Author(s)
      Yang, X., Zhu, L., Tada, S., Zhou, D., Kitajima, T., Isoshima, T., Yoshida, Y., Nakamura, M., Yan, W., Ito, Y
    • Journal Title

      International Journal Nanomedicine

      Volume: 29 Pages: 2753-2765

    • DOI

      10.2147/ijn.s60624

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel, visible light-induced, rapidly cross-linkable gelatin scaffold for osteochondral tissue engineering2014

    • Author(s)
      Tetsuro Mazaki, Yasuyuki Shiozaki, Kentaro Yamane, Aki Yoshida, Mariko Nakamura, Yasuhiro Yoshida, Di Zhou, Takashi Kitajima, Masato Tanaka, Yoshihiro ito, Toshifumi Ozaki, and Akihiro Matsukawa
    • Journal Title

      Sci. Rep.

      Volume: 4 Issue: 1 Pages: 4457-4457

    • DOI

      10.1038/srep04457

    • NAID

      120005526619

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel, visible light-induced, rapidly cross-linkable gelarin scaffold for osteochondral tissue engineering2014

    • Author(s)
      Mazaki, T., Shiozaki, Y., Yamane, K., Yoshida, A., Nakamura, M., Yoshida, Y., Zhou, D., Kitajima, T., Tanaka, M., Ito, Y., Ozaki, T., Matsukawa, A.
    • Journal Title

      Scientific Reports

      Volume: 4

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced in vivo osteogenesis by nanocarrier-fused BMP42013

    • Author(s)
      Y. Shiozaki
    • Journal Title

      Int. J. Nanomed.

      Volume: 8 Pages: 1349-1360

    • DOI

      10.2147/ijn.s44124

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 家兎骨軟骨欠損モデルにおける可視光硬化ゼラチンおよび骨髄間質細胞の組織修復効果2013

    • Author(s)
      香川洋平、馬崎哲朗、塩崎泰之、山根健太郎、吉田晶、松川昭博、中村真理子、吉田靖弘、北嶋隆、伊藤嘉浩、尾崎敏文
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      千葉
    • Related Report
      2013 Final Research Report
  • [Presentation] 可視光硬化ゼラチンとcollagen binding domain(CBD)-BMP4の併用による家兎骨軟骨組織修復効果2013

    • Author(s)
      馬崎哲朗、塩崎泰之、山根健太郎、香川洋平、篠原健介、吉田晶、松川昭博、中村真理子、吉田靖弘、北嶋隆、伊藤嘉浩、尾崎敏文
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      千葉
    • Related Report
      2013 Final Research Report
  • [Presentation] 可視光硬化ゼラチンとcollagen binding domain(CBD)-BMP4の併用による家兎骨軟骨組織修復効果2013

    • Author(s)
      馬崎哲朗,塩崎泰之,山根健太郎,香川洋平,篠原健介,吉田晶,松川昭博,中村真理子,吉田靖弘,北嶋隆,伊藤嘉浩,尾崎敏文
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      幕張メッセ国際会議場,東京ベイホテル
    • Related Report
      2013 Annual Research Report
  • [Presentation] 家兎軟骨欠損モデルにおける可視光硬化ゼラチンおよび骨髄間質細胞の組織修復能2013

    • Author(s)
      香川洋平,馬崎哲朗,塩崎泰之,山根健太郎,吉田晶,松川昭博,中村真理子,吉田靖弘,北嶋隆,伊藤嘉浩,尾崎敏文
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      幕張メッセ国際会議場,東京ベイホテル
    • Related Report
      2013 Annual Research Report
  • [Presentation] コラーゲン結合性骨形成蛋白質BMP4の骨芽細胞に対する影響2012

    • Author(s)
      吉田晶、古松毅之、塩崎泰之、馬崎哲朗、松川昭博、中村真理子、吉田靖弘、北嶋隆、伊藤嘉浩、尾崎敏文
    • Organizer
      第48回日本移植学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] マウスを用いた遺伝子改変成長因子Collagen binding domain BMP4の効果2012

    • Author(s)
      塩崎泰之、馬崎哲朗、山根健太郎、吉田靖弘、中村真理子、北嶋隆、伊藤嘉浩、尾崎敏文、松川昭博
    • Organizer
      第34回日本バイオマテリアル学会大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] ウサギの骨欠損モデルにおいてコラーゲン結合性骨形成蛋白質は骨形成を促進する2012

    • Author(s)
      吉田晶、塩崎泰之、馬崎哲朗、古松毅之、松川昭博、中村真理子、吉田靖弘、北嶋隆、伊藤嘉浩、尾崎敏文
    • Organizer
      第34回日本バイオマテリアル学会大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 家兎骨軟骨欠損モデルにおける可視硬化ゼラチンの骨軟骨組織修復の効果2012

    • Author(s)
      馬崎哲朗、塩崎泰之、吉田晶、松川昭博、中村真理子、吉田靖弘、北嶋隆、伊藤嘉浩、尾崎敏文
    • Organizer
      第34回日本バイオマテリアル学会大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] コラーゲン結合型BMP4の骨芽細胞に対する影響2012

    • Author(s)
      吉田晶、馬崎哲朗、塩崎泰之、古松毅之、松川昭博、中村真理子、吉田靖弘、北嶋隆、伊藤嘉浩、尾崎敏文
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] ウサギの骨欠損モデルにおけるコラーゲン結合性骨形成蛋白質の有効性2012

    • Author(s)
      馬崎哲朗、塩崎泰之、吉田晶、松川昭博、中村真理子、吉田靖弘、北嶋隆、伊藤嘉浩、尾崎敏文
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] Phosphorylated pullulan bioadhesive for regeneration and reconstruction of bone and tooth2012

    • Author(s)
      Yoshida, Y., Okihara, T., Nakamura, M., Matsumoto, T.
    • Organizer
      Bioceramics-24
    • Place of Presentation
      Fukuoka
    • Related Report
      2013 Final Research Report
  • [Presentation] Visible Light-Induced Crosslinkable Gelatin for Direct Pulp Capping2012

    • Author(s)
      Nakamura, M., Yoshida, Y., Ito, Y.
    • Organizer
      Bioceramics-24
    • Place of Presentation
      Fukuoka
    • Related Report
      2013 Final Research Report
  • [Presentation] Phosphorylated pullulan bioadhesive for regeneration and reconstruction of bone and tooth2012

    • Author(s)
      Yasuhiro Yoshida , Takumi Okihara , Mariko Nakamura, Takuya Matsumoto
    • Organizer
      Bioceramics24
    • Place of Presentation
      Fukuoka
    • Related Report
      2012 Research-status Report
  • [Presentation] Visible Light-Induced Crosslinkable Gelatin for Direct Pulp Capping2012

    • Author(s)
      Mariko Nakamura, Yasuhiro Yoshida, Yoshihiro Ito
    • Organizer
      Bioceramics24
    • Place of Presentation
      Fukuoka
    • Related Report
      2012 Research-status Report
  • [Book] Visible Light-Induced Crosslinkable Gelatin for Direct Pulp Capping2013

    • Author(s)
      Nakamura, M., Yoshida, Y., Ito, Y.
    • Publisher
      Key Engineering Materials
    • Related Report
      2013 Final Research Report
  • [Book] Phosphorylated pullulan bioadhesive for regeneration and reconstruction of bone and tooth2013

    • Author(s)
      Yoshida, Y., Okihara, T., Nakamura, M., Matsumoto, T.
    • Publisher
      Key Engineering Materials
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 生体硬組織接着用キット2013

    • Inventor(s)
      吉田靖弘, 田中雅人, 鈴木一臣, 尾崎敏文, 高畑智宏, 入江正郎, 中村真理子, 河島光伸, 野尻大和, 岡田浩一, 長尾昌浩
    • Industrial Property Rights Holder
      国立大学法人岡山大学, 学校法人順正学園
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-01-11
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 生体埋込型医療機器被覆用組成物2012

    • Inventor(s)
      吉田靖弘ほか
    • Industrial Property Rights Holder
      吉田靖弘ほか
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-203876
    • Filing Date
      2012-09-15
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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