Novel bone regenerative medicine with secretome from stem cells cultivated under the regulation of Wnt signaling pathway
| Project/Area Number |
23592883
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIMI Ryoko 名古屋大学, 医学部附属病院, 医員 (40547543)
OHYA Morimichi 名古屋大学, 医学部附属病院, 医員 (70597864)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 骨再生 / 歯周組織再生 / 培養上清 / 成長因子 / 幹細胞 / サイトカイン / 骨再生医療 / 歯周組織 / 液性因子 / Wntシグナル |
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| Research Abstract |
We confirmed that secretome from the stem cell conditioned media (MSC-CM) regenerated bone and periodontal tissue defect. MSC-CM enhanced the migration and the expression of osteogenic and angiogenic related gene expressions of the stem cells cultivated with MSC-CM. Moreover, bone and periodontal tissue regeneration were confirmed using the animal models. This study revealed that MSC-CM induced the migration of stem cells and bone and periodontal defect were regenerated through the angiogenesis.
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Report
(4 results)
Research Products
(38 results)
