3-dimensional and histo-pathological examination on the bone augmentation using bone growth factor and bone substitute
| Project/Area Number |
23592891
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | University of the Ryukyus (2014-2015)
Kagoshima University (2011-2013) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA NORIFUMI 鹿児島大学, 大学院医歯学総合研究科, 教授 (60217875)
TAMATSU YUICHI 鹿児島大学, 大学院医歯学総合研究科, 准教授 (80266569)
MATSUYAMA TAKASHI 鹿児島大学, 大学院医歯学総合研究科, 准教授 (40253900)
ARASAKI AKIRA 琉球大学, 大学院医学研究科, 教授 (00175960)
GOTO TAKAHIRO 琉球大学, 医学部附属病院, 助教 (60578912)
MAKISHI SHOKO 琉球大学, 医学部附属病院, 助教 (60457679)
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| Project Period (FY) |
2011-04-28 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 骨造成 / 骨補填材 / 骨成長因子 / βTCP / 第二世代濃縮血小板 / 人工骨補填剤 / 骨造成手術 / 歯科用インプラント / 顎骨再建術 / 骨補填剤 / 骨造成術 / ＣＧＦ / 破骨細胞 / 骨芽細胞 / コーンビームCT / CGF |
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| Outline of Final Research Achievements |
In this present study, the effects of bone growth factor and bone substitute on the bone augmentation by three-dimensional (3-D) and histopathological evaluation were examinated. 3-D evaluation was used cone bean CT and histopathological was HE staining and TRAP or ALP immunostaining. The bone augmentation was performed by the materials using autologous bone alone and the mixed bone growth factor (PRP or CGF) and a bone substitutes (HA or HA + b-TCP or b-TCP). The bone augmentation using only bone growth factor was not sufficiently observed on the 3-D and histopathological evaluation. On the other hand, the bone augmentation using the materials mixed bone growth factor and bone substitute is observed enough.
The bone resorption on this bone was small than that on the bone using the autologous bone alone.
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Report
(6 results)
Research Products
(19 results)
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[Presentation] 二次的顎裂部骨移植術再考後の短期成績2014
Author(s)
西原一秀, 大河内孝子, 松永和秀, 岐部俊郎, 松本幸三, 前田綾, 宮脇正一, 中村典史
Organizer
第38回日本口蓋裂会学術総会・学術集会,
Place of Presentation
札幌コンベンションセンター、札幌
Year and Date
2014-05-29 – 2014-05-30
Related Report
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