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3-dimensional and histo-pathological examination on the bone augmentation using bone growth factor and bone substitute

Research Project

Project/Area Number 23592891
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionUniversity of the Ryukyus (2014-2015)
Kagoshima University (2011-2013)

Principal Investigator

Nishihara kazuhide  琉球大学, 医学(系)研究科(研究院), 准教授 (30253892)

Co-Investigator(Kenkyū-buntansha) NAKAMURA NORIFUMI  鹿児島大学, 大学院医歯学総合研究科, 教授 (60217875)
TAMATSU YUICHI  鹿児島大学, 大学院医歯学総合研究科, 准教授 (80266569)
MATSUYAMA TAKASHI  鹿児島大学, 大学院医歯学総合研究科, 准教授 (40253900)
ARASAKI AKIRA  琉球大学, 大学院医学研究科, 教授 (00175960)
GOTO TAKAHIRO  琉球大学, 医学部附属病院, 助教 (60578912)
MAKISHI SHOKO  琉球大学, 医学部附属病院, 助教 (60457679)
Project Period (FY) 2011-04-28 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords骨造成 / 骨補填材 / 骨成長因子 / βTCP / 第二世代濃縮血小板 / 人工骨補填剤 / 骨造成手術 / 歯科用インプラント / 顎骨再建術 / 骨補填剤 / 骨造成術 / CGF / 破骨細胞 / 骨芽細胞 / コーンビームCT / CGF
Outline of Final Research Achievements

In this present study, the effects of bone growth factor and bone substitute on the bone augmentation by three-dimensional (3-D) and histopathological evaluation were examinated. 3-D evaluation was used cone bean CT and histopathological was HE staining and TRAP or ALP immunostaining. The bone augmentation was performed by the materials using autologous bone alone and the mixed bone growth factor (PRP or CGF) and a bone substitutes (HA or HA + b-TCP or b-TCP). The bone augmentation using only bone growth factor was not sufficiently observed on the 3-D and histopathological evaluation. On the other hand, the bone augmentation using the materials mixed bone growth factor and bone substitute is observed enough.
The bone resorption on this bone was small than that on the bone using the autologous bone alone.

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (19 results)

All 2016 2015 2014 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 3 results) Presentation (9 results) Book (1 results)

  • [Journal Article] 歯科用インプラント埋入後の上顎洞関連合併症の検討2015

    • Author(s)
      田中荘子、西原一秀、野添悦郎、新崎 章、中村典史
    • Journal Title

      日本口腔インプラント学会誌

      Volume: 28 Pages: 45-51

    • NAID

      130005109568

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcome following secondary autogenous bone grafting before and after canine eruption in patients with unilateral cleft lip and palate.2014

    • Author(s)
      Kazuhide Nishihara, Etsuro Nozoe, Aya Maeda, Narihiro Hirahara, Takako Okawachi, Syouichi Miyawaki, Norifumi Nakamura
    • Journal Title

      Cleft Palate-Craniofacial J

      Volume: 51 Pages: 165-171

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in grafted autogenous bone during Edgewise treatment in patients with unilateral cleft lip/palate or alveolus.2014

    • Author(s)
      Aya Maeda, Sawako Uehara, Mayu Suga, Kazuhide Nishihara, Norifumi Nakamura, Shouichi Miyawaki
    • Journal Title

      Cleft Palate-Craniofacial J

      Volume: 51 Pages: 525-532

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Short-term molding effects on the upper alveolar arch following unilateral cleft lip repair with/without nasal vestibular expansion.2014

    • Author(s)
      Takao Fuchigami, Norifumi Nakamura, Kazuhide Nishihara, Kazuhide Matsunaga, Hiroko Hasegawa:
    • Journal Title

      Cleft Palate-Craniofacial J

      Volume: 51 Pages: 557-568

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Surgical strategy for primary bilateral cleft lip and palate and short-term outcomes in comparison to those of healthy children.2013

    • Author(s)
      Kouzou Matsumoto, Etsuro Noze, Kazuhide Matsunaga, Kazuhide Nishihara, Hiroko Hasegawa, Norifumi Nakamura
    • Journal Title

      Oral Science International

      Volume: 10 Pages: 1-7

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 小児期の片側性唇裂外鼻二次修正術の三次元的解析2013

    • Author(s)
      大河内孝子, 野添悦郎, 平原成浩, 西原一秀, 松永和秀,中村典史
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 59 Pages: 301-310

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 口唇裂•口蓋裂における構音重症度評価の試み-構音正発率と構音点の後方化による 評価-2013

    • Author(s)
      緒方祐子, 手塚征宏, 今村亜子, 新中須真奈, 松永和秀, 西原一秀, 中村典史
    • Journal Title

      日本口蓋裂学会雑誌

      Volume: 38 Pages: 77-85

    • NAID

      130004885962

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Topographic Analysis of Maxillary Premolars and Molars and Maxillary Sinus using Cone Beam Computed Tomography2012

    • Author(s)
      Shin-ichiro Yoshimine, Kazuhide Nishihara, Etsuro Nozoe, Masako Yoshimine, Norifumi Nakamura
    • Journal Title

      Implant Dentistry.

      Volume: 21 Pages: 528-535

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Outcome Following Secondary Autogenous Bone Grafting Before and After Canine Eruption in Patients With Unilateral Cleft Lip and Palate2012

    • Author(s)
      Kazuhide Nishihara, Etsuro Nozoe, Aya Maeda, Narihiro Hirahara, Takako Okawachi, Shouichi Miyawaki and Norifumi Nakamura
    • Journal Title

      The Cleft Palate-Craniofacial Journal

      Volume: 49

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 下顎骨エナメル上皮腫切除後に腸骨移植術とインプラント治療による咬合再建を行った1症例2016

    • Author(s)
      西原一秀、野添悦郎、末廣史雄、中村典史、新崎 章
    • Organizer
      第33回日本口腔インプラント学会九州支部学術大会
    • Place of Presentation
      佐賀市文化会館(佐賀市)
    • Year and Date
      2016-01-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Short-term outcomes after a modifying protocol of secondary autogenous bone grafting in our clinic2014

    • Author(s)
      K. Nishihara , T. Okawachi, K. Matsunaga, T. KIbe, K. Matsumoto, N. Kimura, S. Makishi, T. Goto, N. Nakamura, A. Arasaki
    • Organizer
      The 4th ICPF Workshop in conjunction with 5th Conference of MAOMS
    • Place of Presentation
      Ulaanbaatar、Mongolia
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 二次的顎裂部骨移植術再考後の短期成績2014

    • Author(s)
      西原一秀, 大河内孝子, 松永和秀, 岐部俊郎, 松本幸三, 前田綾, 宮脇正一, 中村典史
    • Organizer
      第38回日本口蓋裂会学術総会・学術集会,
    • Place of Presentation
      札幌コンベンションセンター、札幌
    • Year and Date
      2014-05-29 – 2014-05-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 顎裂部骨移植術を行うひとのためのコツとポイント2013

    • Author(s)
      西原一秀
    • Organizer
      公益社団法人 日本口腔外科学会総会・学術大会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] Outcome following secondary autogenous bone grafting in patients with unilateral cleft lip and aveolus with/ without palate.2013

    • Author(s)
      Kazuhide Nishihara, Toshiro Kibe, Takao Fuchigami, Takako Okawachi, Etsuro Nozoe, Norifumi Nakamura
    • Organizer
      12th Iternational Congress on Cleft Lip/Palate abd Related Craniofacial Anomalies.
    • Place of Presentation
      Florida, USA.
    • Related Report
      2013 Research-status Report
  • [Presentation] Nasal vestibular expansion at primary lip repair affects forward growth of the upper alveolar arch of unilateral cleft lip and palate.2013

    • Author(s)
      Norifumi Nakamura, Takao Fuchigami, Kazuhide Nishihara, Kazuhide Matsunaga, Hiroko Hasegawa
    • Organizer
      12th Iternational Congress on Cleft Lip/Palate abd Related Craniofacial Anomalies.
    • Place of Presentation
      Florida, USA.
    • Related Report
      2013 Research-status Report
  • [Presentation] 当科における二次的顎裂部骨移植術の術後評価2013

    • Author(s)
      西原一秀, 岐部敏郎, 松本幸三, 渕上貴央, 大河内孝子, 野添悦郎, 中村典史
    • Organizer
      第67回 NPO法人日本口腔科学会学術集会
    • Place of Presentation
      栃木県宇都宮市
    • Related Report
      2013 Research-status Report
  • [Presentation] 唇顎口蓋裂患者に対する二次的顎裂部骨移植術の術後評価2012

    • Author(s)
      西原一秀、岐部敏郎、松本幸三、渕上貴央、松永和秀、大河内孝子、中村典史
    • Organizer
      24回 日本小児口腔外科学会総会・学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] 当院を受診したインプラント治療に関する偶発症・合併症患者の臨床的検討2012

    • Author(s)
      西原一秀、松山孝司、松井竜太郎、野添悦郎、中村典史
    • Organizer
      第42回公益社団法人日本口腔インプラント学会・学術大会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Book] 今日の治療指針2013年2013

    • Author(s)
      西原一秀
    • Total Pages
      3000
    • Publisher
      医学書院,
    • Related Report
      2013 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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