Biofunctionalization of titanium oral implant by DLC coating and chemical modifications.

• Project/Area Number: 23592895
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: ENDO Kazuhiko 北海道医療大学, 歯学部, 教授 (70168821)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 口腔インプラント / DLCコーティング / 化学修飾 / 耐食性 / 細胞適合性 / ぬれ性 / 細胞付着 / 細胞増殖 / 抗菌性 / DLC膜 / 生体親和性 / 純チタン / 生体活性化

Research Abstract

The present study was aimed to develop a novel titanium implant with high durability and biofunctionality by coating DLC film together with chemical surface modifications. The corrosion resistance of the titanium in acidic fluoride solution was significantly improved by coated DLC film using the PBIID method, suggesting that the DLC coatings prevent surface roughness due to corrosion. It was also suggested that chemical modifications of the DLC coated titanium with cell adhesive proteins or antibacterial molecule was effective in producing the oral titanium implant with improved biofunctionalities such as high cytocompatible and antibacterial properties.

Research Products

• [Journal Article] Frictional and mechanical properties of diamond-like carbon-coated orthodontic brackets (2013)
  • Author(s): T. Muguruma, M. Iijima, W. A. Brantley, S. Nakagaki, K. Endo, I. Mizoguchi
  • Journal Title: Eur. J. Orthod. Volume: 35 Pages: 216-222
  • Peer Reviewed
• [Journal Article] Frictional and mechanical properties of diamond-like carbon-coated orthodontic brackets (2013)
  • Author(s): Takeshi Muguruma, et al.
  • Journal Title: The European Journal of Orthodontics Volume: 35 Issue: 2 Pages: 216-222
  • DOI: 10.1093/ejo/cjr113
  • Peer Reviewed
• [Presentation] Evaluation of MC3T3-E1 responses to DLC-coated titanium (2014)
  • Author(s): A. B. Dithi, H. Toshima, Y. Ida, F. Nagano-Takebe, K. Endo
  • Organizer: 32th Annual Meeting of Dental Society of Health Sciences University of Hokkaido
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2014-03-01
• [Presentation] Evaluation of MC3T3-E1 responses to DLC-coated titanium (2014)
  • Author(s): Akashlynn Badruddoza Dithi, Hirokazu Toshima, Yusukue Ida, Futami Nagano-Takebe, Kazuhiko Endo
  • Organizer: 32th Annual Meeting of Dental Society of Health Sciences University of Hokkaido
  • Place of Presentation: Health Sciences University of Hokkaido
• [Presentation] DLC膜をコーティングした純チタンの疑似体液中における腐食挙動 (2012)
  • Author(s): 遠藤一彦, 飯嶋雅弘, 井田有亮, 橋本正則, 長野二三, 戸島洋和、溝口到
  • Organizer: 第60回日本歯科理工学会学術講演会
  • Place of Presentation: 九州大学医学部百年講堂, 福岡市
• [Presentation] Corrosion resistance of diamond-like carbon-coated titanium in fluoride solutions (2012)
  • Author(s): K. Endo, M. Iijima, M. Hashimoto, F. Nagano, Y. Ida, H. Toshima, I. Mizoguchi
  • Organizer: International Association of Dental Research (IADR)
  • Place of Presentation: Convention Center (Iguassu fall, Brasil)
• [Presentation] Corrosion resistance of diamond-like carbon-coated titanium in fluoride solutions (2012)
  • Author(s): K. ENDO, M. IIJIMA, M. Hashimoto, F. Nagano, Y. IDA, K. H. TOSHIMA and I. MIZOGUCHI
  • Organizer: Intenational Association of Dental Research (IADR)
  • Place of Presentation: Convention Center (Iguassu fall (Brasil)