| Project/Area Number |
23592923
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
OKAMOTO KOSEI 広島大学, 病院(歯), 病院助教 (40423371)
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| Co-Investigator(Kenkyū-buntansha) |
KURIHARA Hidemi 広島大学, 医歯薬保健学研究院(歯), 教授 (40161765)
OKAMOTO Tetsuji 広島大学, 医歯薬保健学研究院(歯), 教授 (00169153)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 歯学 / 再生医学 |
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| Research Abstract |
With a mesenchyma system stem cell (MSC) derived from establishment marrow, I examined it in a serum-free medium for embryonic stem cells.
In CD90 (Thy-1), CD105 (Endogrlin) which was a marker gene of the MSC, and gene Oct3/4, Nanog where expression was accepted with an undifferentiated human embryonic stem cell, expression was recognized in the MSC of which condition that added FGF-1, FGF-2, LIF, activin A and heparin in POWEREDBY10 or hESF7 nutrient medium. In addition, expression was accepted in the MSC which I cultured in hESF9 and hESF10 nutrient medium equally. Possibility to become the index of the undifferentiation voltinism of the MSC was suggested.
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