Prognosis of oral squamous cell carcinoma patients using gene expression profile and immunological status.
| Project/Area Number |
23592976
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Asahi University |
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Principal Investigator |
KONDOH Nobuo 朝日大学, 歯学部, 教授 (40202072)
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| Co-Investigator(Kenkyū-buntansha) |
KITAGAWA Yoshimasa 北海道大学, 大学院歯学研究科, 教授 (00224957)
YAMAZAKI Yutaka 北海道大学, 大学院歯学研究科, 教授 (90250464)
TOHNAI Iwai 横浜市立大学, 大学院歯学研究科, 教授 (50172127)
MITSUDO Kenji 横浜市立大学, 大学院歯学研究科, 准教授 (70303641)
SHIKIMORI Michio 朝日大学, 大学院歯学研究科, 教授 (70154193)
TAKAYAMA Eiji 朝日大学, 大学院歯学研究科, 准教授 (70533446)
MURAMATSU Yasunori 朝日大学, 大学院歯学研究科, 教授 (30247556)
MOTOHASHI Masayuki 朝日大学, 大学院歯学研究科, 講師 (80396390)
IZUMO Toshiyuki 東京医科歯科大学, 歯学部附属病院, 准教授 (80322709)
KAWAKI Harumi 朝日大学, 大学院歯学研究科, 講師 (70513670)
KAMIYA-MIZUNO Masako 朝日大学, 大学院歯学研究科, 助教 (80181907)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 口腔扁平上皮癌 / 遺伝子発現 / 免疫細胞診断 / Tリンパ球 / ＩＦＮ-γ / CD57 / IFN-γ / CD4+T-NK細胞 |
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| Research Abstract |
In order to diagnose overall status of OSCC patients, we evaluated immunological activity using peripheral blood samples from the patients. We first examined cytokine levels in peripheral blood, and cytokine producing-capability of LPS-stimulated peripheral blood cells (PBLs) from the patients. Our results demonstrated that the production of a Th1 cytokine, IFN-g by LPS-stimulated PBLs from OSCC patients was significantly down regulated in accordance with the tumor progression from stages I up to III. By contrast, the production of IFN-g was up-regulated from PBLs of the patients harboring lymphnode metastasis compared to that of the patients without metastasis. On the other hand, proportion of CD57+T lymphocytes among PBLs was increased along with the tumor progression from stages I up to IV.
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Report
(5 results)
Research Products
(75 results)
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[Journal Article] Altered cytokine levels and increased CD4^+CD57^+ T cells in the peripheral blood of hepatitis C virus-related hepatocellular carcinoma patients2011
Author(s)
Shiraki T, Takayama E, Magari H, Nakata T, Maekita T, Enomoto S, Mori Y, Shingaki N, Moribata K, Deguchi H, Ueda K, Inoue I, Mizuno-Kamiya M, Yashiro K, Iguchi M, Tamai H, Kameyama Y, Kato J, Kondoh N, Ichinose M
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Journal Title
Oncol Rep
Volume: 26(1)
Pages: 201-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Altered cytokine levels and increased CD4+CD57+ T cells in the peripheral blood of hepatitis C virus-related hepatocellular carcinoma patients.2011
Author(s)
Shiraki T, Takayama E, Magari H, Nakata T, Maekita T, Enomoto S, Mori Y, Shingaki N, Moribata K, Deguchi H, Ueda K, Inoue I, Mizuno-Kamiya M, Yashiro K, Iguchi M, Tamai H, Kameyama Y, Kato J, Kondoh N, Ichinose M
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Journal Title
Oncol Rep.
Volume: 26
Issue: 1
Pages: 201-208
Related Report
Peer Reviewed
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[Presentation] 象牙質・幹細胞複合体の骨再生への応用2013
Author(s)
田中雅士, 小栗健策, 森春菜, 川木晴美, 近藤信夫, 吉田隆一
Organizer
第138回日本歯科保存学会2013年度春季学術大会
Place of Presentation
福岡
Year and Date
2013-06-27 – 2013-06-28
Related Report
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[Presentation] 培養幹細胞に対する象牙質顆粒の機能解析2013
Author(s)
小栗健策, 田中雅士, 森春菜, 川木晴美, 近藤信夫, 吉田隆一
Organizer
第138回日本歯科保存学会2013年度春季学術大会
Place of Presentation
福岡
Year and Date
2013-06-27 – 2013-06-28
Related Report
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[Presentation] CD4+ CD57+ T cells and cytokine producing capabilities in peripheral blood from oral squamous cell carcinoma patients.2012
Author(s)
NAGANAWA K, TAKAYAMA E, ADACHI M, BABA J, IIDA M, MITSUDO K, Masao ICHINOSE, Yasunori MURAMATSU, Iwai TOHNAI, SHIKIMORI M, KONDOH, N.
Organizer
第71回日本癌学会学術総会
Place of Presentation
札幌
Year and Date
2012-09-19 – 2012-09-21
Related Report
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[Presentation] CD4^+ CD57^+ T cells and cytokine producing capabilities in peripheral blood from oral squamous cell carcinoma patients2012
Author(s)
NAGANAWA K, TAKAYAMA E, ADACHI M, BABAJ, IIDA M, MITSUDO K, Masao ICHINOSE, Yasunori MURAMATSU, Iwai TOHNAI, SHIKIMORI M, KONDOH N
Organizer
第71回癌学会学術総会
Place of Presentation
札幌
Related Report
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[Presentation] CD4+ CD57+ T cells and cytokine producing capabilities in peripheral blood from oral squamous cell carcinoma patients.2012
Author(s)
Kousuke NAGANAWA, Eiji TAKAYAMA, Makoto ADACHI, Junichi BABA, Masaki IIDA, Kenji MITSUDO, Masao ICHINOSE, Yasunori MURAMATSU, Iwai TOHNAI, Michio SHIKIMORI, Nobuo KONDOH.
Organizer
第71回癌学会学術総会
Place of Presentation
札幌
Related Report
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