| Project/Area Number |
23592984
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUZAWA Hitoshi 新潟大学, 脳研究所, 准教授 (70303170)
SEO Kenji 新潟大学, 医歯学系, 教授 (40242440)
TANAKA Yutaka 新潟大学, 医歯学総合病院, 講師 (50323978)
TSURUMAKI Tatsuru 新潟大学, 医歯学系, 助教 (10345522)
KURATA Shigenobu 新潟大学, 医歯学系, 助教 (20464018)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 三叉神経 / 下歯槽神経 / 舌神経 / 神経障害性疼痛 / MRI / 3DAC / 神経イメージング / 神経MRI / 拡散強調画像 / 高分解能画像 / 神経腫 / 神経損傷 / 末梢神経 / Neurography / 高分解能3D画像 / 神経再生 / Nuerography / Schwann細胞 |
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| Outline of Final Research Achievements |
In order to visualize human peripheral nerve disorder noninvasively, two high-resolution MRI methods, namely, high spatial- and contrast-resolution imaging were established and applied in a clinical setting in this investigation. The imaging successfully delineated the morphologies associated with abnormally regenerated nerve and overgrown scar tissue in patients with chronic neuropathic pain in the trigeminal nerve. The current imaging is considered to reflect pathological nerve histology, and may contribute a diagnosis and a decision on the course of treatments for trigeminal neuropathy.
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