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The mechanism of pupil dilation response during cold pressor test

Research Project

Project/Area Number 23593001
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionNihon University

Principal Investigator

OKA Shunichi  日本大学, 歯学部, 准教授 (20256879)

Co-Investigator(Kenkyū-buntansha) SUZUKI Naoto  日本大学, 歯学部, 教授 (10226532)
OKADA Akiko  日本大学, 歯学部, 准教授 (10434078)
NAKAJIMA Ichiro  日本大学, 歯学部, 教授 (90198078)
OI Yoshiyuki  日本大学, 歯学部, 教授 (60271342)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords瞳孔 / 痛み / ストレス / 唾液 / ホルモン / ストレスホルモン / αアミラーゼ / コルチゾール / 自律神経反射
Research Abstract

Dental treatments accompany the stress. This study was evaluated the mechanism of pupil dilation response(PDR) during cold pressor test. One competing hypothesis for the PDR was that PDR was that like the pupillary light reflex, it was not a simple reflexive response.
Cold pressor test increased the value of alpha-amylase at during and 1~3 min, that of cortisol at 10~12 min and 20~22 min after stress. The stress came from cold presser test induced the exciting of sympathetic nerve system using Heart Rate Variability. Pupil dilated immediately after cold presser test, at 30~60 sec.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (17 results)

All 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (11 results) Book (1 results)

  • [Journal Article] 高齢者における唾液中αアミラーゼと歯科治療時間について2012

    • Author(s)
      中西穂波、岡俊一、石井宏卓、金博和、見崎徹、大井良之
    • Journal Title

      日歯麻誌

      Volume: 40 Pages: 201-202

    • NAID

      10030554943

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of the actin cytoskeleton and localization of theα6β1 andα3 integrins during regeneration of the rat submandibular gland2012

    • Author(s)
      Shimizu O、Shiratsuchi H、Ueda K、Oka S、Oi Y
    • Journal Title

      Arch Oral Biol

      Volume: 57 Pages: 1127-1132

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 高齢者におけるαアミラーゼと歯科治療時間について2012

    • Author(s)
      中西穂波、岡俊一
    • Journal Title

      日本歯科麻酔学会雑誌

      Volume: 40 Pages: 201-202

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 高齢者における唾液中αアミラーゼと歯科治療時間について2012

    • Author(s)
      中西穂波
    • Journal Title

      日本歯科麻酔学会雑誌

      Volume: 40巻

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Influence of blood pressure on cardio-ankle vascular index (CAVI) examined based on percentage change during general anesthesia2011

    • Author(s)
      Kim B、Takada K、Oka S、Misaki T
    • Journal Title

      Hypertens Res

      Volume: 34 Pages: 779-783

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Human salivaryα-amylase during cold pressor test2013

    • Author(s)
      Oka S、Nakanishi H、Oi Y、Suzuki N
    • Organizer
      FDI 2013 Istanbul Annual World Dental Congress
    • Place of Presentation
      Istanbul、Turkey
    • Year and Date
      2013-08-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 東京都葛飾区における在宅寝たきり老人の歯科治療(第14報)高齢者における唾液量とストレスホルモンの関係2013

    • Author(s)
      鈴木勲、岡俊一、鈴木直人、大井良之他9名
    • Organizer
      日本老年歯科医学会第24回学術大会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2013-06-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 東京都葛飾区における在宅寝たきり老人の歯科治療(第14報)高齢者における唾液量とストレスホルモンの関係2013

    • Author(s)
      鈴木勲、岡俊一、金博和、見崎徹、原田昇、篠原保行、勝俣文良、白橋知幸、山崎一男、小松孝至、中西穂波、鈴木直人、大井良之
    • Organizer
      日本老年歯科医学会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Human salivary α‐amylase during cold pressor test2013

    • Author(s)
      Oka Shunichi, Nakanishi Honami, Shimizu Osamu, Suzuki Naoto, Oi Yoshiyuki
    • Organizer
      FDI 2013 Istanbul Annual World Dental Congress
    • Place of Presentation
      Istanbul (Turkey)
    • Related Report
      2013 Annual Research Report
  • [Presentation] プロポフォールの単一抑制性シナプス伝達増強作用はシナプスを形成するニューロンサブタイプにより異なる2013

    • Author(s)
      小柳裕子、一杉岳、内田琢也、金博和、高田耕司、岡俊一、見崎徹、大井良之
    • Organizer
      第41回日本歯科麻酔学会総会
    • Place of Presentation
      新横浜国際ホテル(横浜)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 歯科治療時のαアミラーゼの変動2012

    • Author(s)
      岡俊一、中西穂波、里見ひとみ、関野麗子、金博和、鈴木直人、大井良之
    • Organizer
      第22回日本歯科医学会総会・学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2012-11-10
    • Related Report
      2013 Final Research Report
  • [Presentation] 東京都葛飾区における在宅寝たきり老人の歯科治療(第13報)高齢者における唾液中ストレスホルモンと歯科治療時間について2012

    • Author(s)
      大原義治、岡俊一、他11名
    • Organizer
      日本老年歯科医学会第23回学術大会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2012-06-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Propofol reduces the pupil dilation response to noxious stimulation in humans2012

    • Author(s)
      Oka S、Nakanishi H、Oi Y、Suzuki N
    • Organizer
      15^<th> WFSA World Congress of Anaesthesiologists
    • Place of Presentation
      Buenos Aires、Argentina
    • Year and Date
      2012-03-27
    • Related Report
      2013 Final Research Report
  • [Presentation] PROPOFOL REDUCES THE PUPIL DILATION RESPONSE TO NOXIOUS STIMULATION IN HUMANS2012

    • Author(s)
      Shunichi Oka
    • Organizer
      15th World Congress of Anaesthesiologists
    • Place of Presentation
      Buenos Aires Argentina
    • Related Report
      2011 Research-status Report
  • [Presentation] 東京都葛飾区における在宅寝たきり老人の歯科治療 第13報 高齢者における唾液中ストレスホルモンと歯科治療時間について

    • Author(s)
      大原義治
    • Organizer
      日本老年歯科医学会 第23回学術大会
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 歯科治療時のαアミラーゼの変動

    • Author(s)
      岡 俊一
    • Organizer
      第22回日本歯科医学会総会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Related Report
      2012 Research-status Report
  • [Book] Movement -Related Cortical Potentials Associated with Oral and Facial Functions in Humans2012

    • Author(s)
      Nakajima I、Oka S、Ohba H、Yoshida M
    • Total Pages
      398
    • Publisher
      Applications of EMG in Clinical and Sports Medicine
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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