| Project/Area Number |
23593016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OHKUBO Kazumi 東京大学, 保健・健康推進本部, 講師 (10396715)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAHAMA Kouhei 東京大学, 医学部附属病院, 助教 (60401361)
INOGUCHI Takato 東京大学, 医学部附属病院, 助教 (80587775)
SAIJO Hideto 東京大学, 医学部附属病院, 講師 (80372390)
TEI Yuichi 東京大学, 工学(系)研究科(研究院), 教授 (30345053)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 歯科矯正学 / 骨改造現象 / βカテニン / PTH受容体 |
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| Research Abstract |
To investigate the underlying mechanisms of action and functional relevance of b-catenin in osteoblasts, by examining the role of b-catenin as a novel protein that interacts with the intracellular C-terminal portion of the parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor type 1 (PTHR-1). b-catenin physically interacted and co-localized with the cell membrane-specific region of PTHR-1 (584-589). Binding of b-catenin to PTHR-1 caused suppression of the Gs/cAMP pathway and enhancement of the Gq/Ca2+ pathway, without affecting the canonical Wnt pathway. Now, to analyze the mechanism of osteogenic differentiation in vivo, OsxCre:b-catenin flox mice model is treated intermittently with PTH and will be investigate these histological analysis.
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