The mechanism of interaction with parathyroid hormone/parathyroid hormone-related protein receptor signals and Wnt/b-catenin in osteo-remodeling tooth migration model
Project/Area Number |
23593016
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthodontic/Pediatric dentistry
|
Research Institution | The University of Tokyo |
Principal Investigator |
OHKUBO Kazumi 東京大学, 保健・健康推進本部, 講師 (10396715)
|
Co-Investigator(Kenkyū-buntansha) |
NAGAHAMA Kouhei 東京大学, 医学部附属病院, 助教 (60401361)
INOGUCHI Takato 東京大学, 医学部附属病院, 助教 (80587775)
SAIJO Hideto 東京大学, 医学部附属病院, 講師 (80372390)
TEI Yuichi 東京大学, 工学(系)研究科(研究院), 教授 (30345053)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 歯科矯正学 / 骨改造現象 / βカテニン / PTH受容体 |
Research Abstract |
To investigate the underlying mechanisms of action and functional relevance of b-catenin in osteoblasts, by examining the role of b-catenin as a novel protein that interacts with the intracellular C-terminal portion of the parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor type 1 (PTHR-1). b-catenin physically interacted and co-localized with the cell membrane-specific region of PTHR-1 (584-589). Binding of b-catenin to PTHR-1 caused suppression of the Gs/cAMP pathway and enhancement of the Gq/Ca2+ pathway, without affecting the canonical Wnt pathway. Now, to analyze the mechanism of osteogenic differentiation in vivo, OsxCre:b-catenin flox mice model is treated intermittently with PTH and will be investigate these histological analysis.
|
Report
(4 results)
Research Products
(43 results)
-
[Journal Article] Incisor Inclination after Presurgical Orthodontic Treatment in Patients with Mandibular Prognathism2014
Author(s)
Ohkubo K, Susami T, Inokuchi T, Okayasu M, Takahashi N, Uwatoko K, Uchino N, Suenaga H, Koga Y, Saijo H, Mori Y and Takato T
-
Journal Title
The Japanese Journal of Jaw Deformities
Volume: 24
Issue: 1
Pages: 16-26
DOI
NAID
ISSN
0916-7048, 1884-5045
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Incisor inclination after Presurgical Orthodontic Treatment in Patients with Mandibular Prognathism2014
Author(s)
Ohkubo K, Susami T, Inokuchi T, Okayasu M, Takahashi N, Uwatoko K, Uchino N, Suenaga H, Koga Y, Saijo H, et.al
-
Journal Title
The Japanese Journal of Jaw Deformities
Volume: VOL24
Pages: 16-26
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
[Journal Article] 東大病院における口唇裂・口蓋裂患者に対する矯正歯科治療2013
Author(s)
須佐美 隆史, 大久保 和美, 井口 隆人, 岡安 麻里, 内野 夏子, 上床 喜和子, 高橋 直子, 高戸 毅
-
Journal Title
Journal of Japanese Cleft Palate Association
Volume: 38
Issue: 1
Pages: 54-61
DOI
NAID
ISSN
0386-5185, 2186-5701
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
[Presentation] PALATAL INDEX FOR EVALUATION OF THE PALATAL MORPHOLOGY IN PATIENTS WITH UNIATERAL CLEFT LIP AND PALATE2013
Author(s)
Inokuchi T, Susami T, Okayasu M, Uchino N, Uwatoko K, Ohkubo K, Ogasawara T, Saijo H, Mori Y, Takato T
Organizer
12th International Congress on Cleft Lip/Palate and Related Craniofacial Anomalies
Place of Presentation
Florida USA ,Hilton Orlando Lake Buena Vista
Related Report
-
[Presentation] TOOTH ALIGNMENT AT THE ALVEOLAR CLEFT SITE AFTER ORTHODONTIC TREATMENT AND THE NEED OF ORTHOGNATHIC SURGERIES2013
Author(s)
Susami T, Uchino N, Ohkubo K, Inokuchi T ,Okayasu M,Uwatoko K, Ogasawara T, Saijo H, Mori Y, Takato T
Organizer
12th International Congress on Cleft Lip/Palate and Related Craniofacial Anomalies
Place of Presentation
Florida USA ,Hilton Orlando Lake Buena Vista
Related Report
-
[Presentation] NEED FOR ORTHOGNATHIC SURGERY AND ITS PREDICTION IN EARLY MIXED DENTITION IN PATIENTS WITH BILATERAL CLEFT LIP AND PALATE2013
Author(s)
Okayasu M, Susami T, Inocuchi T, Ohkubo K, Uchino N, Uwatoko K, Ogasawara T, Saijo H, Mori Y, Takato T
Organizer
12th International Congress on Cleft Lip/Palate and Related Craniofacial Anomalies
Place of Presentation
Florida USA ,Hilton Orlando Lake Buena Vista
Related Report
-
[Presentation] 混合歯列前期における将来的な顎矯正手術の必要性の予測 両側性唇顎口蓋裂患者について2013
Author(s)
岡安 麻里, 須佐美 隆史, 井口 隆人, 大久保 和美, 内野 夏子, 高橋 直子, 上床 喜和子, 古賀 陽子, 菅野 勇樹, 杉山 円, 西條 英人, 森 良之, 高戸 毅
Organizer
第37回 日本口蓋裂学会総会・学術集会
Place of Presentation
佐賀市文化会館(佐賀県)
Related Report
-
[Presentation] 片側性唇顎口蓋裂における口蓋形態指数と口蓋容積の関連性 咬合と上下顎形成との関連を含めて2013
Author(s)
井口 隆人, 須佐美 隆史, 大久保 和美, 岡安 麻里, 内野 夏子, 上床 喜和子, 高橋 直子, 末永 英之, 西條 英人, 森 良之, 高戸 毅
Organizer
第37回 日本口蓋裂学会総会・学術集会
Place of Presentation
佐賀市文化会館(佐賀県)
Related Report
-
-
-
-
[Presentation] TOOTH ALIGNMENT AT THE ALVEOLAR CLEFT SITE AFTER ORTHODONTIC TREATMENT AND THE NEED OF ORTHOGNATHIC SURGERIES.2013
Author(s)
Susami T, Uchino N, Ohkubo K, Inokuchi T ,Okayasu M,Uwatoko K, Ogasawara T, Saijo H, Mori Y, Takato T
Organizer
12th International Congress on Cleft Lip/Palate and Related Craniofacial Anomalies,
Place of Presentation
Hilton Orlando Lake Buena Vista(アメリカ、フロリダ)
Related Report
-
[Presentation] NEED FOR ORTHOGNATHIC SURGERY AND ITS PREDICTION IN EARLY MIXED DENTITION IN PATIENTS WITH BILATERAL CLEFT LIP AND PALATE.2013
Author(s)
Okayasu M, Susami T, Inocuchi T, Ohkubo K, Uchino N, Uwatoko K, Ogasawara T, Ssaijo H, Mori Y, Takato T:
Organizer
12th International Congress on Cleft Lip/Palate and Related Craniofacial Anomalies,
Place of Presentation
Hilton Orlando Lake Buena Vista(アメリカ、フロリダ)
Related Report
-
[Presentation] PALATAL INDEX FOR EVALUATION OF THE PALATAL MORPHOLOGY IN PATIENTS WITH UNIATERAL CLEFT LIP AND PALATE.2013
Author(s)
Inokuchi T, Susami T, Okayasu M, Uchino N, Uwatoko K, Ohkubo K, Ogasawara T, Saijo H, Mori Y, Takato T.
Organizer
12th International Congress on Cleft Lip/Palate and Related Craniofacial Anomalies,
Place of Presentation
Hilton Orlando Lake Buena Vista(アメリカ、フロリダ)
Related Report
-
-
-
-
[Presentation] Maxillary Protraction in Patients with Cleft Lip and Palate : Evaluation after Facial2011
Author(s)
Susami T, Ohkubo K, Nagahama K Takahashi N, Uchino N, Okayasu M, Uwatoko K, Seto I, Saijyo H, Mori Y, Takato T
Organizer
9th European Craniofacial Congress
Place of Presentation
Salzburg, Austria, Salzburg Congress
Related Report
-
[Presentation] Outcome of the Surgical-Orthodontic Treatment for Cleft Patients using the Two-stage Maxillary Distraction-Mandibular Setback Osteotomies2011
Author(s)
Susami T, Mori Y, Ohkubo K, Nagahama K, Saijyo H, Takahashi N, Uchino N, Okayasu M, Uwatoko K, Seto I, Takato T
Organizer
9th European Craniofacial Congress
Place of Presentation
Salzburg, Austria, Salzburg Congress
Related Report
-
[Presentation] Implant-type tissue-engineered cartilage applied for the nasal correction of the cleft lip and palate patients2011
Author(s)
Takato T, Mori Y, Saijo H, Kanno Y, Kurabayashi K, Sugiyama M, Susami T, Ohkubo K, Okayasu M, Uchino N, Nishizawa S, Fujihara Y, Hoshi K
Organizer
9th European Craniofacial Congress
Place of Presentation
Salzburg, Austria, Salzburg Congress
Related Report
-
[Presentation] Implant-Type Tissue-Engineered Cartilage Applied For The Correction Of The Cleft Lip-Nose Patients2011
Author(s)
Takato T, Mori Y, Saijo H, Seto I, Kanno Y, Kurabayashi K, Sugiyama M, Susami T, Ohkubo K, Okayasu M, Uchino N, Nishizawa S, Fujihara Y, Hoshi K
Organizer
in Tissue Engineering and Regenerative Medicine International Society Asia Pacific Meeting
Place of Presentation
Singapore, Waterfront Conference Centre
Related Report
-
-
-
-
-
-
-