Basic research about bone regeneration and oral implant for craniofacial defect patients
Project/Area Number |
23593054
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthodontic/Pediatric dentistry
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Research Institution | Matsumoto Dental University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
MIYAZAWA Hiroo 松本歯科大学, 総合歯科医学研究所, 教授 (90147637)
NAKAMURA Midori 松本歯科大学, 歯学部, 准教授 (90278177)
YAGAMI Kimitoshi 松本歯科大学, 歯学部附属病院, 准教授 (00210211)
UDAGAWA Nobuyuki 松本歯科大学, 歯学部, 教授 (70245801)
NAKAMICHI Yuko 松本歯科大学, 総合歯科医学研究所, 講師 (20350829)
|
Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 骨芽細胞 / 破骨細胞 / 遺伝子欠損マウス / 口蓋裂 / 骨再生 / Rykシグナル / Wntシグナル / 骨誘導因子 / 顎裂 / Ryk欠損マウス / 骨形成 / 骨吸収 / 再生医療 |
Research Abstract |
We generated systemic Ryk signal deficient mice. Ryk deficient mice exhibited a cleft palate and totally decrease of osteoclast number and osteoblast number in bone. Furthermore, we generated osteoclast-specific Ryk-deficient mice and osteoblast-specific Ryk-deficient mice. Interestingly, there are no cleft palate in both osteoclast-specific Ryk-deficient mice and osteoblast-specific Ryk-deficient mice. Osteoclast-specific Ryk-deficient mice have normal bone phenotype. These results suggest that Ryk expression in osteoclasts and osteoblasts is not essential for craniofacial defect.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Noncanonical Wnt5a enhances Wnt/-catenin signaling during osteogenesis.2014
Author(s)
Okamoto, M., Udagawa, N., Yamashita, T., Nakamichi, Y., Uehara, S., Kato, H., Saito, N., Minami, Y., Takahashi, N., Kobayashi, Y.
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Journal Title
Sci. report
Volume: 4
Issue: 1
Pages: 4493-4493
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Stimulation of bone formation in cortical bone of mice treated with a receptor activator of nuclear factor-κB ligand (RANKL)-binding peptide that possesses osteoclastogenesis inhibitory activity.2013
Author(s)
Furuya Y, Inagaki A, Khan M, Mori K, Penninger JM, Nakamura M, Udagawa N, Aoki K, Ohya K, Uchida K, Yasuda H
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Journal Title
J Biol Chem
Volume: 288
Issue: 8
Pages: 5562-5571
DOI
Related Report
Peer Reviewed
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[Journal Article] Wnt5a-Ror2 signaling between osteoblasts and osteoclast precursors enhances osteoclastogenesis2012
Author(s)
Maeda, K., Kobayashi, Y., Udagawa, N., Uehara, S., Ishihara, A., Mizoguchi, T., Kikuchi, Y., Takada, I., Kato, S., Kani, S., Nishita, M., Marumo, K., Martin, T.J., Minami, Y., Takahashi, N.
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Journal Title
Nat.Med.
Volume: (印刷中)
Issue: 3
Pages: 405-12
DOI
Related Report
Peer Reviewed
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[Journal Article] Lineage-Committed Osteoclast Precursors Circulate in Blood and Settle Down Into Bone2011
Author(s)
Muto, A, Mizoguchi, T, Udagawa, N., Ito, S, Kawahara, I, Abiko, Y, Arai, A., Harada, S., Kobayashi, Y., Nakamichi, Y, Penninger, JM, Noguchi, T, Takahashi, N.
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Journal Title
Journal of Bone and Mineral Research
Volume: 26
Issue: 12
Pages: 2978-2990
DOI
Related Report
Peer Reviewed
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