• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Interaction between S1P and DAMPs in periodontal inflammation

Research Project

Project/Area Number 23593057
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Periodontal dentistry
Research InstitutionOsaka University

Principal Investigator

YANAGITA Manabu  大阪大学, 歯学研究科(研究院), 助教 (80379081)

Co-Investigator(Kenkyū-buntansha) YAMADA Satoru  大阪大学, 歯学部附属病院, 講師 (40359849)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords歯周病 / リゾリン脂質 / ダメージ関連分子パターン
Research Abstract

In this study we have investigated the effects of S1P, bioactive lipid mediator, on inflammatory responses of gingival epithelial cells. S1P receptors, S1P2 and S1P3, are expressed in gingival epithelial cells. S1P increased to produce IL-8 from gingival epithelial cells in a dose-dependent manner. S1P-induced IL-8 production upregulated synergistically in the presence of HMGB-1 or Poly(I:C). S1P-induced IL-8 induction was suppressed in S1P2/S1P3 knockdown gingival epithelial cells. These findings suggest that S1P induce inflammation in gingival epithelial cells via S1P2/S1P3.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (42 results)

All 2014 2013 2012 2011 Other

All Journal Article (17 results) (of which Peer Reviewed: 16 results) Presentation (23 results) Book (2 results)

  • [Journal Article] Cooperative effects of FGF-2 and VEGF-A in periodontal ligament cells2014

    • Author(s)
      Yanagita M, Kojima Y, Kubota M, Mori K, Yamashita M, Yamada S, Kitamura M, Murakami S
    • Journal Title

      Journal of Dental Research

      Volume: 93 Pages: 89-95

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cooperative effects of FGF-2 and VEGF-A in periodontal ligament cells2014

    • Author(s)
      Yanagita M, Kojima Y, Kubota M, Mori K, Yamashita M, Yamada S, Kitamura M, Murakami S.
    • Journal Title

      Journal of Dental Research

      Volume: 93 Pages: 89-95

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periodontal Regeneration and FGF-22013

    • Author(s)
      Kojima Y, Yanagita M, Yamada S, Kitamura M and Murakami S
    • Journal Title

      Inflammation and Regeneration

      Volume: 33 Pages: 72-77

    • NAID

      130004943834

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nicotine modulates the immunological function of dendritic cells through PPAR-gamma expression2012

    • Author(s)
      Yanagita M, Kobayashi R, Kojima Y, K Mori and Murakami S
    • Journal Title

      Cellular Immunology

      Volume: 274 Pages: 26-33

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nicotine upregulates IL-8 serection in human gingival epithelial cells following stimulation with IL-1beta or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signaling2012

    • Author(s)
      Kashiwagi Y, Yanagita M, Kojima Y, Shimabukuro Y and Murakami S
    • Journal Title

      Archives of Oral Biology

      Volume: 57 Pages: 483-490

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin regulates functions of gingival fibroblasts and periodontal ligament cells2012

    • Author(s)
      Iwayama T, Yanagita M, Mori K, Ozasa M, Sawada K, Kubota M, Miki K, Kojima Y, Takedachi M, Kitamura M, Shimabukuro Y, Hashikawa T and Murakami S
    • Journal Title

      Journal of Periodontal Research

      Volume: 47 Pages: 563-571

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunomodulation of Dendritic Cells Differentiated in the Presence of Nicotine with Lipopolysaccharide From Porphyromonas gingivalis2012

    • Author(s)
      Yanagita M, Mori K, Kobayashi R, Kojima Y, Miki K, Kubota M, Yamada S, Kitamura M and Murakami S
    • Journal Title

      European Journal of Oral Sciences

      Volume: 120 Pages: 408-414

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin regulates functions of gingival fibroblasts and periodontal ligament cells.2012

    • Author(s)
      Iwayama T, Yanagita M, Mori K, Sawada K, Kubota M, Miki K, Kojima Y, Takedachi M, Kitamura M, Shimabukuro Y, Hashikawa T and Murakami S
    • Journal Title

      Journal of Periodontal Research

      Volume: 47 Pages: 565-571

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunomodulation of dendritic cells differentiated in the presence of nicotine with lipopolysaccharide from Porphyromonas gingival is.2012

    • Author(s)
      Yanagita M, Mori K, Kobayashi R, Kojima Y, Kubota M, Miki K, Yamada S, Kitamura M and Murakami S
    • Journal Title

      European Journal of Oral Sciences

      Volume: 120 Pages: 408-414

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of ferritin in the cytodifferentiation of periodontal ligament cells2012

    • Author(s)
      Hou J, Yamada S, Kajikawa T, Ozaki N, Awata T, Yamaba S, Murakami S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 426 Issue: 4 Pages: 643-648

    • DOI

      10.1016/j.bbrc.2012.09.008

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nicotine upregulates IL-8 serection in human gingival epithelial cells following stimulation with IL-1β or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signaling.2012

    • Author(s)
      Kashiwagi Y, Yanagita M*, Kojima Y, Shimabukuro Y and Murakami S
    • Journal Title

      Archives of Oral Biology

      Volume: 57 Issue: 5 Pages: 483-490

    • DOI

      10.1016/j.archoralbio.2011.10.007

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adiponectin regulates functions of gingival fibroblasts and periodontal ligament cells2012

    • Author(s)
      T.Iwayama, M.Yanagita, K.Mori, K.Sawada, M.Ozasa, M.Kubota, K.Miki, Y.Kojima, M.Takedachi, M.Kitamura, Y.Shimabukuro, T.Hashikawa, S.Murakami
    • Journal Title

      J.Periodont.Res.

      Volume: (印刷中) Issue: 5 Pages: 563-571

    • DOI

      10.1111/j.1600-0765.2012.01467.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nicotine modulates the immunological function of dendritic cells through PPAR-γ expression.2012

    • Author(s)
      Yanagita M, Kobayashi R, Kojima Y, K Mori and Murakami S.
    • Journal Title

      Cellular Immunology

      Volume: 274 Issue: 1-2 Pages: 26-33

    • DOI

      10.1016/j.cellimm.2012.02.007

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] ニコチンによる樹状細胞の機能修飾2012

    • Author(s)
      柳田学、森健太、村上伸也
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 45 Pages: 249-253

    • Related Report
      2011 Research-status Report
  • [Journal Article] Fibroblast growth factor-2 stimulates directed migration of periodontal ligament cells via PI3-K/akt signaling and CD44/hyaluronan interaction2011

    • Author(s)
      Shimabukuro Y, Terashima H, Takedachi M, Maeda K, Nakamura T, Sawada K, Kobashi M, Awata T, Oohara H, Kawahara T, Iwayama T, Hashikawa T, Yanagita M, Yamada S and Murakami S
    • Journal Title

      Journal of Cellular Physiology

      Volume: 226 Issue: 3 Pages: 809-821

    • DOI

      10.1002/jcp.22406

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Periodontal disease in a Prader-Willi syndrome patient.2011

    • Author(s)
      Yanagita M, Hirano H, Kobashi M, Nozaki T, Yamada S, Kitamura M and Murakami S
    • Journal Title

      Journal of Medical Case Reports

      Volume: 5 Issue: 1 Pages: 329-329

    • DOI

      10.1186/1752-1947-5-329

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Osteoinductive and anti-inflammatory effect of royal jelly on periodontal ligament cells.2011

    • Author(s)
      Yanagita M, Kojima Y, Mori K, Yamada S and Murakami S
    • Journal Title

      Biomedical Research

      Volume: 32 Pages: 285-291

    • NAID

      130004903826

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 塩化カルプロニウムが歯根膜細胞および血管内皮細胞に及ぼす影響2013

    • Author(s)
      三木康史、柳田学、その他
    • Organizer
      第56回秋季日本歯周病学会
    • Place of Presentation
      前橋
    • Year and Date
      2013-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] DAMPs possibly trigger inflammatory responses in human gingival epithelial cells2013

    • Author(s)
      Mori K, Yanagita M, Kubota M, Yamaba S, Yamashita M, Yamada S, Kitamura M, Murakami S
    • Organizer
      第二回国際歯科研究学会アジア太平洋地区学術大会
    • Place of Presentation
      バンコク市、タイ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Carpronium chloride promotes the calcification of periodontal ligament cells2013

    • Author(s)
      Miki K, Yanagita M, Mori K, Kubota M, Yamashita M, Yamada S, Kitamura M, Murakami S.
    • Organizer
      第二回国際歯科研究学会アジア太平洋地区学術大会
    • Place of Presentation
      バンコク市、タイ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Immunological properties of murine periodontal ligament cells2012

    • Author(s)
      Mori K, Yanagita M, Kubota M, Kojima Y, Yamaba S, Yamada S, Kitamura M, Murakami S
    • Organizer
      第60回国際歯科研究学会日本部会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2012-12-14
    • Related Report
      2013 Final Research Report
  • [Presentation] FGF-2刺激による歯根膜細胞からのCXCR4の誘導2012

    • Author(s)
      久保田実木子、柳田学、その他
    • Organizer
      第137回秋季日本歯科保存学会
    • Place of Presentation
      広島
    • Year and Date
      2012-11-22
    • Related Report
      2013 Final Research Report
  • [Presentation] スフィンゴシン−1−リン酸がヒト歯肉上皮細胞の炎症反応に及ぼす影響2012

    • Author(s)
      三木康史、柳田学、その他
    • Organizer
      第136回春季日本歯科保存学会
    • Place of Presentation
      宜野湾
    • Year and Date
      2012-06-29
    • Related Report
      2013 Final Research Report
  • [Presentation] FGF-2 induces VEGF expression by periodontal ligament cells2012

    • Author(s)
      Kojima Y, Yanagita M,その他
    • Organizer
      90th IADR
    • Place of Presentation
      Iguacu Falls, Brazil
    • Related Report
      2013 Final Research Report
  • [Presentation] FGF-2 induces VEGF expression by periodontal ligament cells2012

    • Author(s)
      Kojima Y, Yanagita M, Mori K, Murakami S
    • Organizer
      98^<th> American Academy of Periodontology Annual Meeting
    • Place of Presentation
      Los Angels, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Cooperative effects of FGF-2 and VEGF in periodontal ligament cells2011

    • Author(s)
      Kojima Y, Yanagita M, Mori K, Yamashita M, Nozaki T, Yamada S,その他
    • Organizer
      第59回国際歯科研究学会日本部会学術大会
    • Place of Presentation
      広島
    • Year and Date
      2011-10-08
    • Related Report
      2013 Final Research Report
  • [Presentation] スフィンゴシン−1−リン酸がヒト歯肉線維芽細胞の炎症反応に及ぼす影響2011

    • Author(s)
      森健太、柳田学、その他
    • Organizer
      第54回日本歯周病学会秋季学術大会
    • Place of Presentation
      下関
    • Year and Date
      2011-09-24
    • Related Report
      2013 Final Research Report
  • [Presentation] TLR2/TLR3共刺激が歯肉上皮細胞の免疫応答に及ぼす影響2011

    • Author(s)
      森健太、柳田学、児嶋由子、中村友美、山下元三、山田聡、その他
    • Organizer
      第134回春季日本歯科保存学会
    • Place of Presentation
      千葉
    • Year and Date
      2011-06-08
    • Related Report
      2013 Final Research Report
  • [Presentation] FGF-2により誘導される血管新生への歯根膜細胞の関与2011

    • Author(s)
      児嶋由子、柳田学、森健太、山下元三、山田聡、その他
    • Organizer
      第32回日本炎症・再生医学会
    • Place of Presentation
      京都
    • Year and Date
      2011-06-03
    • Related Report
      2013 Final Research Report
  • [Presentation] FGF-2により誘導される血管新生へのマウス歯根膜細胞の関与2011

    • Author(s)
      児嶋由子、柳田学、森健太、野崎剛徳、山田聡、その他
    • Organizer
      第54回日本歯周病学会春季学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2011-05-28
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト歯根膜細胞におけるインフラマゾームの発現2011

    • Author(s)
      山羽聡子、山田聡、梶川哲宏、尾崎亘弘、粟田敏仁、柳田学、その他
    • Organizer
      第55回日本歯周病学会春季学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-18
    • Related Report
      2013 Final Research Report
  • [Presentation] TLR2/TLR3共刺激が歯肉上皮細胞の免疫応答に及ぼす影響2011

    • Author(s)
      森健太、柳田学、児嶋由子、中村友美、山下元三、山田聡、北村正博、村上伸也
    • Organizer
      第134回春季日本歯科保存学会
    • Place of Presentation
      東京ベイ舞浜ホテルクラブリゾート( 千葉県  )
    • Related Report
      2011 Research-status Report
  • [Presentation] スフィンゴシン-1-リン酸がヒト歯肉線維芽細胞の炎症反応に及ぼす影響2011

    • Author(s)
      森健太、柳田学、児嶋由子、久保田実木子、山田聡、北村正博、村上伸也
    • Organizer
      第54回日本歯周病学会秋季学術大会
    • Place of Presentation
      海峡メッセ下関( 山口県 )
    • Related Report
      2011 Research-status Report
  • [Presentation] ヒト歯根膜細胞の老化により誘導されるSASPの解析

    • Author(s)
      池上久仁子、山下元三、山羽聡子、中村友美、森健太、粟田敏仁、柳田学、北村正博、村上伸也
    • Organizer
      第138回秋季日本歯科保存学会
    • Place of Presentation
      福岡市、福岡県
    • Related Report
      2013 Annual Research Report
  • [Presentation] 塩化カルプロニウムが歯根膜細胞および血管内皮細胞に及ぼす影響

    • Author(s)
      三木康史、柳田学、伊山舜吉、森健太、久保田実木子、山下元三、山田聡、北村正博、村上伸也
    • Organizer
      第56回秋季日本歯周病学会
    • Place of Presentation
      前橋市、群馬県
    • Related Report
      2013 Annual Research Report
  • [Presentation] イムノクロマト法を用いた歯肉浸出液中のカルプロテクチン測定による歯周病診断

    • Author(s)
      木戸淳一、永田俊彦、多部田康一、山崎和久、吉江弘正、渡辺久、和泉雄一、須田玲子、山本松男、柴秀樹、栗原英見、柳田学、北村正博、南部敏之、水野光春、村上伸也
    • Organizer
      第56回秋季日本歯周病学会
    • Place of Presentation
      前橋市、群馬県
    • Related Report
      2013 Annual Research Report
  • [Presentation] 歯根膜特異的分子PLAP-1による炎症制御機構解明

    • Author(s)
      山羽聡子、山田聡、粟田敏仁、阪下裕美、津島賢一朗、梶川哲宏、柳田学、北村正博、村上伸也
    • Organizer
      第139回秋季日本歯科保存学会
    • Place of Presentation
      秋田市、秋田県
    • Related Report
      2013 Annual Research Report
  • [Presentation] スフィンゴシン-1-リン酸がヒト歯肉上皮細胞の炎症反応に及ぼす影響

    • Author(s)
      三木康史、柳田学、森健太、久保田実木子、伊山舜吉、竹立匡秀、山下元三、山田聡、北村正博、村上伸也
    • Organizer
      第136回春季日本歯科保存学会
    • Place of Presentation
      宜野湾市、沖縄県
    • Related Report
      2012 Research-status Report
  • [Presentation] Immunological properties of murine periodontal ligament cells

    • Author(s)
      Mori K, Yanagita M, Kubota M, Kojima Y, Yamaba S, Yamada S, Kitamura M, Murakami S
    • Organizer
      第60回国際歯科研究学会日本部会学術大会
    • Place of Presentation
      新潟市、新潟県
    • Related Report
      2012 Research-status Report
  • [Presentation] Expression analysis of inflammasome in periodontal tissues

    • Author(s)
      Yamaba S, Yamada S, Kajikawa T, Ozaki N, Awata H, Sakashita H, Yanagita M, Kitamura M, Murakami S
    • Organizer
      第60回国際歯科研究学会日本部会学術大会
    • Place of Presentation
      新潟市、新潟県
    • Related Report
      2012 Research-status Report
  • [Book] ザ・ペリオドントロジー 第二版2014

    • Author(s)
      柳田学、村上伸也 (編集主幹:和泉雄一、木下淳博、沼部幸博、山本松男)
    • Total Pages
      279
    • Publisher
      永末書店
    • Related Report
      2013 Annual Research Report
  • [Book] 炎症性メディエーターと歯周疾患の関係;ザ・ペリオドントロジー第二版2013

    • Author(s)
      柳田学、村上伸也
    • Publisher
      永末書店
    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi