Development of a new tooth coating with antibacterial property by using new biomaterial of Calcium Titanate

• Project/Area Number: 23593088
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Okayama University
• Principal Investigator: KISHIMOTO Etsuo 岡山大学, 医歯(薬)学総合研究科, 准教授 (20091316)
• Co-Investigator(Kenkyū-buntansha): TAMAMURA Ryo 日本大学, 松戸歯学部, 助教 (00403494) ; TAKAGI Shin 岡山大学, 大学院医歯薬学総合研究科, 准教授 (40116471) ; NAGATSUKA Hitoshi 岡山大学, 大学院医歯薬学総合研究科, 教授 (70237535)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: チタン酸カルシウム / 生体材料 / 歯質コーティング / チタン酸 / 抗菌 / 齲蝕 / 歯周病

Research Abstract

The objective of this study was the development of a new tooth coating method for prevention of caries and periodontitis by using calcium titanate nanoparticles. We have been able to produce CaTiO3-C with antibiotic properties that gave satisfying results against carious and periodontal bacteria.
We expected that this new coating material could be of a great utility in the future.

Research Products

• [Journal Article] Ultrastructure of cement lines (2013)
  • Author(s): Okada H, Tamamura R, Kanno T, Nakada H, Yasuoka S, Arikawa K, Kato T, Kaneda T, Davies JE
  • Journal Title: J Hard Tissue Biol Volume: 22(4) Pages: 445-50
  • NAID: 130004480615
  • Peer Reviewed
• [Journal Article] Ultrastructure of cement lines. (2013)
  • Author(s): Okada H, Tamamura R, Kanno T, Nakada H, Yasuoka S, Arikawa K, Kato T, Kaneda T, Davies JE.
  • Journal Title: J Hard Tissue Biol Volume: 22 Pages: 445-450
  • NAID: 130004480615
  • Peer Reviewed
• [Journal Article] Bone-healing pattern on critical-sized defects treated by rhPTH (2012)
  • Author(s): Jammal MV, Pastorino NF, Abate CM, Takagi S, Nagatsuka H, Missana LR
  • Journal Title: J Hard Tissue Biol Volume: 21(4) Pages: 443-450
  • NAID: 130004848391
  • Peer Reviewed
• [Journal Article] Bone-healing pattern on critical-sized defects treated by rhPTH. (2012)
  • Author(s): Jammal MV
  • Journal Title: J Hard Tissue Biol. Volume: 21 Pages: 443-450
  • Peer Reviewed
• [Journal Article] Effect of Fluoride-substituted Apatite on In Vivo Bone Formation (2011)
  • Author(s): Inoue M, Rodriguez AP, Nagai N, Nagatsuka H, Legeros RZ, Tsujigiwa H, Inoue M, Kishimoto E, Takagi S
  • Journal Title: J Biomater Appl Volume: 25(8) Pages: 811-824
  • Peer Reviewed
• [Journal Article] Effect of Fluoride-substituted Apatite on In Vivo Bone Formation. (2011)
  • Author(s): Inoue M
  • Journal Title: J Biomater Appl Volume: 25 Pages: 811-824
  • Peer Reviewed
• [Presentation] Cement lineの電顕的研究 (2013)
  • Author(s): 岡田裕之、玉村亮、菅野岳志、桑田隆生、鈴木久二博、中田浩史、安岡沙織、小林良喜、有川量崇、田口千恵子、加藤仁夫、金田隆、寒河江登志朗
  • Organizer: 第22回硬組織再生生物学会学術大会・総会
  • Place of Presentation: 横浜
  • Year and Date: 2013-08-22
• [Presentation] インプラントの骨組織反応と将来への展望 (2012)
  • Author(s): 長塚仁
  • Organizer: 日本再生歯科医学会設立10周年記念セミナー
  • Place of Presentation: 神戸
  • Year and Date: 2012-09-02
• [Presentation] Cement lineの電顕的研究
  • Author(s): 岡田裕之、玉村 亮、菅野岳志、桑田隆生、鈴木久二博、中田浩史、安岡沙織、小林良喜、有川量崇、田口千恵子、加藤仁夫、金田 隆、寒河江登志朗
  • Organizer: 硬組織再生生物学会
  • Place of Presentation: 鶴見大学歯学部（神奈川県横浜市）
• [Presentation] インプラントの骨組織反応と将来への展望
  • Author(s): 長塚 仁
  • Organizer: 日本再生歯科医学会
  • Place of Presentation: 神戸
  • Invited