| Project/Area Number |
23593098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Ohu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAMAI Riyoko 奥羽大学, 歯学部, 准教授 (90367566)
SUGAMATA Miho (70530377)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | 口腔カンジダ症 / Candida albicans / 誤嚥性肺炎 / 炎症性サイトカイン / 口腔ケア / 抗菌ペプチド / 免疫抑制剤 |
|---|
| Research Abstract |
Production of the mycotic stomatitis model using three kinds of different immunosuppressants (prednisolone, cyclosporin, methotrexate) was tried. As a result, in the mouse which performed immune suppression disposal by prednisolone on the day preceding a tongue application of Candida albicans, Remarkable weight loss was accepted three days after infection, and the pathological change formation (decomposition, an ulcer, and white moss) according to fixing of the bacillus of 10000 orders and human mycotic stomatitis was seen with the tongue. In the cyclosporin A and methotrexate, although two or more times inoculation and high-dose inoculation of a medicine were also tried, neither resulted in pathological change formation. That is, it was suggested that the cyclosporin A and methotrexate are difficult for model production of the mycotic stomatitis in a mouse.
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