Nicotine promote bone resorption through the vascular endothelial cells
| Project/Area Number |
23593099
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Ohu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 歯学 / 細胞 / 歯周病 / 喫煙 / 血管内皮細胞 / 骨吸収 |
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| Research Abstract |
In this study used human vein endothelial cells to examine whether nicotine regulated production of cytokines which promoted bone resorption in vitro. Nicotine inhibited the mRNA expression of osteoprotegerin in the HUVEC. In contrast, nicotine promoted the mRNA expression receptor activator of nuclear factor kappa-B ligand to promote bone resorption from the HUVEC. These results provide fundamental knowledge that indicates strongly that smoking is a risk factor for periodontal disease.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] .: Anti-cell-associated glucosyltransferase immunoglobulin Y suppression of salivary mutans streptococci in healthy young adults.2011
Author(s)
Nguyen,VS., Icatolo,FC., Nakano,T., Isogai,E., Hirose,K., Mizugai,H., Kobayashi,M., Isogai,H., Chiba,I.
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Journal Title
J. American Dental Ass.
Volume: 142
Pages: 943-949
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