Development of novel screening method based on the visualization of permeability distribution of cell layer
| Project/Area Number |
23615001
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Reliable environmental measurement methods
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| Research Institution | Tohoku University |
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Principal Investigator |
MIYAMOTO Koichiro 東北大学, 工学(系)研究科(研究院), 准教授 (70447142)
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| Co-Investigator(Kenkyū-buntansha) |
HAN Jyunkyu 筑波大学, 生命環境科学研究科, 准教授 (40455928)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 化学センサ / タイトジャンクション / スクリーニング / 細胞アッセイ / 化学イメージセンサ / 安全環境計測法 / 化学イメージング |
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| Research Abstract |
Chemical image sensor is a sensor which can visualize the ion distribution in the electrolyte. In this study, a portable chemical imaging system which is small, inexpensive and working stand-alone was developed. In addition to that, the visualization of resistivity distribution of cultured-cell layer was succeeded. It indicates that the visualization of the tight-junction based on electrical property will be possible in the future. Based on this result, novel screening assay to evaluate the influence of chemicals to the cells can be also expected.
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Report
(4 results)
Research Products
(19 results)
