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Epigenetic regulation of primary lymphoid organ microenvironment

Research Project

Project/Area Number 23616003
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field epigenetics
Research InstitutionHiroshima University

Principal Investigator

KANNO Masamoto  広島大学, 医歯薬保健学研究院(医), 教授 (40161393)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsポリコーム / タンパク質複合体 / KOマウス / lincRNA / 胸腺 / T細胞分化 / エピジェネティックス / リンパ球分化 / RNA / noncoding RNA / 蛋白質複合体 / 胸腺内T細胞分化 / ポリコーム蛋白質複合体 / 国際情報交流 / 英国・スイス / lncRNA / 胸腺上皮細胞
Research Abstract

We succeeded to purify thymic development stage specific PRC1 protein complexes. At ETP stage, PRC1.2 is major form of PRC1, however, at DN3 PRC1.4 form of PRC1 is major form. This corresponds well for the phenotype of different PCGF gene KO mice. We also succeeded to establish several floxed PcG gene KO mice. Also we identified new lincRNA with might bind with PRC2

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (17 results)

All 2014 2013 2012 2011

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (12 results)

  • [Journal Article] The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs.2013

    • Author(s)
      Yuko Atsumi, Aki lnase, Eiji Sugihara, Ryo Sakasai, Hiroaki Fujimori, Hirobumi Teraoka, Hideyuki Saya, Masamoto Kanno, Fumio Tashiro, Hitoshi Nakagami, Mitsuko Masutani, Ken-ichi Yoshioka
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 288巻 Issue: 19 Pages: 13269-13277

    • DOI

      10.1074/jbc.m112.402560

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor2012

    • Author(s)
      Sugihara E, Saya H, et al
    • Journal Title

      Oncogene

      Volume: (印刷中) Issue: 23 Pages: 2849-2861

    • DOI

      10.1038/onc.2011.462

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A methyl-deficient diet modifies early B cell development2012

    • Author(s)
      T. Kurogi
    • Journal Title

      Pathobiology

      Volume: 79 Issue: 4 Pages: 209-218

    • DOI

      10.1159/000337290

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mel-18 controls the enrichment of tumor-initiating cells in SP fraction in mouse breast cancer2011

    • Author(s)
      Janakiraman H, Nobukiyo A, Inoue H, Kanno M
    • Journal Title

      Hiroshima J Med Sci

      Volume: 60(2) Pages: 25-35

    • NAID

      120005323960

    • URL

      http://ir.lib.hiroshima-u.ac.jp/metadb/up/kiyo/AA00664312/HiroshimaJMedSci_60_25.pdf

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polycomb group gene Bmi1 plays a role in the growth of thymic epithelial cells2011

    • Author(s)
      Guo Y, Miyazaki M, Itoi M, Satoh R, Iwama A, Amagai T, Kawamoto H, Kanno M
    • Journal Title

      Eur J Immunol

      Volume: 41 Issue: 4 Pages: 1098-1107

    • DOI

      10.1002/eji.201040794

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Heterogeneity of Polycomb Repressive Complexes (PRCs) and long-noncoding RNA dictate the regulation network of intra-thymic T cell development2014

    • Author(s)
      Masamoto Kanno, Yun Guo, Yoshinori Ohno and Yoshihiro Takihara
    • Organizer
      4th International Symposium of RIRBM
    • Place of Presentation
      Hiroshima/JAPAN
    • Related Report
      2013 Annual Research Report
  • [Presentation] Heterogeneity of Polycomb repressive complexes and long-noncoding RNA dictate the regulation network of thymic T cell development2013

    • Author(s)
      M. Kanno, Y. Guo, W.S. Kong, A. Nobukiyo, H. Inoue
    • Organizer
      15^<th> International congress of Immunology
    • Place of Presentation
      Milan/Italy
    • Related Report
      2013 Final Research Report
  • [Presentation] Polycomb Connection between Coronary Artery Disease Risk and Irradiation-Regeneration process of Thymus via Long-noncoding RNA2013

    • Author(s)
      M.Kanno, A.Nobukiyo, Y.Ohno, Y.Takihara, Y.Guo
    • Organizer
      3rd International Symposium of RIRBM
    • Place of Presentation
      Hiroshima University(Hiroshima Japan)
    • Related Report
      2013 Final Research Report
  • [Presentation] Heterogeneity of Polycomb repressive complexes and long-noncoding RNA dictate the regulation network of thymic T cell development2013

    • Author(s)
      Masamoto Kanno, Yun Guo, Kong Weng Sheng, Asako Nobukiyo, and Hiroko Inoue
    • Organizer
      15th International Congress of Immunology 2013
    • Place of Presentation
      Milan/ITALY
    • Related Report
      2013 Annual Research Report
  • [Presentation] Arfとp53に依存的なヒストンH2AXの低下と静止状態2012

    • Author(s)
      大澤智之, 熱海悠子, 杉原英志, 佐谷秀行, 菅野雅元, 田代文夫, 益谷美都子, 吉岡研一
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] 抗癌剤存在下での優先的な癌細胞死と正常細胞の生存に資するArf/p53依存的H2AX制御機構2012

    • Author(s)
      熱海悠子, 稲瀬安希, 杉原英志, 佐谷秀行, 菅野雅元, 益谷美都子, 吉岡研一
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] UVに応答した核内のIKKbetaを介したNF-kappaB活性化と細胞死2012

    • Author(s)
      土谷佳弘, 金本麻裕, 浅野知一郎, 菅野雅元, 鎌田英明
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] Arfとp53に依存的なヒストンH2AXの低下と静止状態2012

    • Author(s)
      大澤 智之,熱海 悠子,杉原 英志,佐谷 秀行,菅野 雅元,田代 文夫,益谷 美都子,吉岡 研一
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] 抗癌剤存在下での優先的な癌細胞死と正常細胞の生存に資するArf/p53依存的H2AX制御機構2012

    • Author(s)
      熱海 悠子,稲瀬 安希,杉原 英志,佐谷 秀行,菅野 雅元,益谷 美都子,吉岡 研一
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] UVに応答した核内のIKKbetaを介したNF-kappaB活性化と細胞死2012

    • Author(s)
      土谷 佳弘,金本 麻裕,浅野 知一郎,菅野 雅元,鎌田 英明
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] The function of Bmi-1 in the thymic epithelial cells2011

    • Author(s)
      ・ Yun Guo, Masaki Miyzaki, Manami Itoi, Takashi Amagai, Rumi Satoh, Hiroshi Kawamoto, Masamoto Kanno
    • Organizer
      日本免疫学会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2011 Research-status Report
  • [Presentation] The impact of metabolism of methylation: importance of methyl donor for epigenetic reggulation of lymphocyte2011

    • Author(s)
      masamoto KANNO
    • Organizer
      kyoto T cell conference
    • Place of Presentation
      京都平安ホテル
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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