Epigenetic regulation of primary lymphoid organ microenvironment
| Project/Area Number |
23616003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
epigenetics
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| Research Institution | Hiroshima University |
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Principal Investigator |
KANNO Masamoto 広島大学, 医歯薬保健学研究院(医), 教授 (40161393)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ポリコーム / タンパク質複合体 / KOマウス / lincRNA / 胸腺 / T細胞分化 / エピジェネティックス / リンパ球分化 / RNA / noncoding RNA / 蛋白質複合体 / 胸腺内T細胞分化 / ポリコーム蛋白質複合体 / 国際情報交流 / 英国・スイス / lncRNA / 胸腺上皮細胞 |
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| Research Abstract |
We succeeded to purify thymic development stage specific PRC1 protein complexes. At ETP stage, PRC1.2 is major form of PRC1, however, at DN3 PRC1.4 form of PRC1 is major form. This corresponds well for the phenotype of different PCGF gene KO mice. We also succeeded to establish several floxed PcG gene KO mice. Also we identified new lincRNA with might bind with PRC2
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] The Arf/p53 protein module, which induces apoptosis, down-regulates histone H2AX to allow normal cells to survive in the presence of anti-cancer drugs.2013
Author(s)
Yuko Atsumi, Aki lnase, Eiji Sugihara, Ryo Sakasai, Hiroaki Fujimori, Hirobumi Teraoka, Hideyuki Saya, Masamoto Kanno, Fumio Tashiro, Hitoshi Nakagami, Mitsuko Masutani, Ken-ichi Yoshioka
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Journal Title
The Journal of Biological Chemistry
Volume: 288巻
Issue: 19
Pages: 13269-13277
DOI
Related Report
Peer Reviewed
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