Involvement of the metabolism pathway of S-Adenosyl methionine in epileptics
| Project/Area Number |
23616007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
epigenetics
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| Research Institution | National Institute of Agrobiological Sciences |
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Principal Investigator |
YOSHIKAWA Manabu 独立行政法人農業生物資源研究所, 植物・微生物間相互作用研究ユニット, 主任研究員 (80391564)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | エピジェネティク制御 / S-アデノシルメチオニン / メチオニン代謝 |
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| Research Abstract |
In epigenetics, cytosines, histones and siRNAs are methylated. S-Adenosyl methionine (SAM) is used as a donor of methyl grope to them. However, it is unknown whether SAM is related to epigenetics in plants. To address this point, I performed this study using Arabidopsis mutants that are defective in SAM metabolisms. I explore transposons that are up-regulated in SAM metabolism defective mutants. I found that a few transposons are up-regulated in the mutants among some transposons. Next I analyzed the status of DNA methylation of up-regulated transposons. These results showed that DNA methylation at a locus is affected in SAM metabolism defective mutants and some epigenetic mutants. This observation implies that SAM metabolism is related to epigenetic regulation.
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Report
(4 results)
Research Products
(8 results)
