| Project/Area Number |
23617001
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Hokkaido University |
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Principal Investigator |
KAMEYAMA Takeshi 北海道大学, 遺伝子病制御研究所, 研究員 (40569505)
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| Co-Investigator(Kenkyū-buntansha) |
HAYAKAWA Sumio 北海道大学, 遺伝子病制御研究所, 助教 (00368292)
ADACHI Yoshihiro Christopher 北海道大学, 遺伝子病制御研究所, 博士研究員 (10616204)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAOKA Akinori 北海道大学, 遺伝子病制御研究所, 教授 (30323611)
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| Research Collaborator |
OKADA Kanako 北海道大学, 理学部, 修士
TODA Haruka 北海道大学, 理学部, 学生
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 自然免疫 / 食餌性核酸 / インターフェロン / 口腔粘膜 / 免疫学 / 栄養学 / 自然免疫賦活化 / 核酸 / 食品 |
|---|
| Research Abstract |
Diet contains various kinds of nutrient,, which keep us healthy. However the nutritional role of nucleic acids derived from diets is not clearly understood. The innate immunity system is an essential step as the front line of host defense. Although oral mucosa acts as powerful barriers, the importance of oral mucosa in innate immunity remains unclear. In this study, we demonstrate that DNA derived from vegetable activated innate immune response both in vitro and in vivo, which may provide the nutritional immunological role of dietary nucleic acids.
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