Longevity function of trehalose and its effects on amyloid formation

• Project/Area Number: 23617041
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrated Nutrition Science
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: HONDA Shuji 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (40100127)
• Co-Investigator(Kenkyū-buntansha): 本田 陽子 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (90399460)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: トレハロース / 老化 / 寿命 / 腎臓 / 脳 / マウス / 老化促進マウス

Outline of Final Research Achievements

Trehalose is a disaccharide of glucose found in diverse organisms. We previously found that treatment of the nematode Caenorhabditis elegans with trehalose extended the mean lifespan by over 30%. To clarify whether trehalose delays the aging processes and lengthens lifespan in mammals, we examined the effects of trehalose treatment on aging and lifespan of mice. Trehalose treatment slightly extended the lifespan of C57 BL/6J male mice and suppressed the age-associated leakage of albumin into the urine. Trehalose treatment also suppressed the age-associated increase in neuronal ubiquitinated inclusions of senescence-accelerated mice (SAM)-P10. These results suggest that trehalose retards the aging processes in mammals.

Research Products

• [Journal Article] 10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling. (2015)
  • Author(s): Honda Y, Araki Y, Hata T, Ichihara K, Ito M, Tanaka M, Honda S.
  • Journal Title: Journal Aging Research Volume: 2015 Pages: 425261-425261
  • DOI: 10.1155/2015/425261
  • Peer Reviewed / Open Access
• [Journal Article] Spaceflight and aging (2014)
  • Author(s): Honda Y, Honda S, Narici M, Szewczyk NJ,
  • Journal Title: Gerontology Volume: 60 Issue: 2 Pages: 138-142
  • DOI: 10.1159/000354772
  • Peer Reviewed / Open Access
• [Journal Article] Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes. (2013)
  • Author(s): Tanisawa K., Mikami E., Fuku N., Honda Y., Honda S., Ohsawa I., Ito M., Endo S., Ihara K., Ohno K., Kishimoto Y., Ishigami A., Maruyama N., Sawabe M., Iseki H., Okazaki Y., Hasegawa-Ishii S., Takei S., Shimada A., Hosokawa M., Mori M., Higuchi K., Takeda T., Higuchi M., Tanaka M.
  • Journal Title: BMC Genomics. Volume: 14(1): Issue: 1 Pages: 248-248
  • DOI: 10.1186/1471-2164-14-248
  • Peer Reviewed / Open Access
• [Presentation] Lifespan-extending effects of royal jelly on nematodes Caenorhabditis elegans. (2014)
  • Author(s): Hata, T, Maruyama H,, Yoko Araki, Ichihara K, Ito M, Honda Y, Honda S,
  • Organizer: Apimondia 5th Apimedica and 4th Apiquality Forum
  • Place of Presentation: Turkey
  • Year and Date: 2014-09-01 – 2014-09-05
• [Presentation] Aging in Space. (2014)
  • Author(s): Honda Y, Higashibata A, Matsunaga Y, Yonezawa Y, Kawano T, Higashitani A, Kuriyama K, Shimazu T, Tanaka M, Szewczyk N J, Ishioka N, Honda S,
  • Organizer: C. elegans Development, Cell Biology & Gene Expression Meeting in association with The 6th Asia-Pacific C. elegans Meeting,
  • Place of Presentation: 奈良 奈良県立公会堂
  • Year and Date: 2014-07-15 – 2014-07-19
• [Presentation] 老化促進モデルマウス（ SAMP10）におけるトレハロースの長期投与の加齢指標におよぼす影響 (2014)
  • Author(s): 本田陽子、本田修二、濱野慶朋、長谷川康子、新井冨生、田中雅嗣
  • Organizer: 老化促進モデルマウス（ SAM）研究協議会第29回研究発表会
  • Place of Presentation: 東京、東京都健康長寿医療センター
  • Year and Date: 2014-07-05 – 2014-07-06
• [Presentation] 老化促進マウス（SAMP10）におけるトレハロースの長期投与の加齢指標に及ぼす影響 (2014)
  • Author(s): 本田陽子、本田修二、濱野慶朋、長谷川康子、新井冨生、田中雅嗣
  • Organizer: 老化促進マウス（SAM）研究協議会研究発表会
  • Place of Presentation: 東京都健康長寿医療センター
• [Book] 老化の生物学 第10章 インスリンシグナル (2014)
  • Author(s): 本田陽子，本田修二，河野強
  • Total Pages: 20
  • Publisher: 化学同人
• [Book] インスリンシグナル（老化の生物学） (2013)
  • Author(s): 本田陽子、本田修二
  • Publisher: 化学同人