Longevity function of trehalose and its effects on amyloid formation
Project/Area Number |
23617041
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Integrated Nutrition Science
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Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
Principal Investigator |
HONDA Shuji 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (40100127)
|
Co-Investigator(Kenkyū-buntansha) |
本田 陽子 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (90399460)
|
Project Period (FY) |
2011-04-28 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | トレハロース / 老化 / 寿命 / 腎臓 / 脳 / マウス / 老化促進マウス |
Outline of Final Research Achievements |
Trehalose is a disaccharide of glucose found in diverse organisms. We previously found that treatment of the nematode Caenorhabditis elegans with trehalose extended the mean lifespan by over 30%. To clarify whether trehalose delays the aging processes and lengthens lifespan in mammals, we examined the effects of trehalose treatment on aging and lifespan of mice. Trehalose treatment slightly extended the lifespan of C57 BL/6J male mice and suppressed the age-associated leakage of albumin into the urine. Trehalose treatment also suppressed the age-associated increase in neuronal ubiquitinated inclusions of senescence-accelerated mice (SAM)-P10. These results suggest that trehalose retards the aging processes in mammals.
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Report
(5 results)
Research Products
(9 results)
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[Journal Article] Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes.2013
Author(s)
Tanisawa K., Mikami E., Fuku N., Honda Y., Honda S., Ohsawa I., Ito M., Endo S., Ihara K., Ohno K., Kishimoto Y., Ishigami A., Maruyama N., Sawabe M., Iseki H., Okazaki Y., Hasegawa-Ishii S., Takei S., Shimada A., Hosokawa M., Mori M., Higuchi K., Takeda T., Higuchi M., Tanaka M.
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Journal Title
BMC Genomics.
Volume: 14(1):
Issue: 1
Pages: 248-248
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Aging in Space.2014
Author(s)
Honda Y, Higashibata A, Matsunaga Y, Yonezawa Y, Kawano T, Higashitani A, Kuriyama K, Shimazu T, Tanaka M, Szewczyk N J, Ishioka N, Honda S,
Organizer
C. elegans Development, Cell Biology & Gene Expression Meeting in association with The 6th Asia-Pacific C. elegans Meeting,
Place of Presentation
奈良 奈良県立公会堂
Year and Date
2014-07-15 – 2014-07-19
Related Report
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