Control of stem cell migration by small chemical compounds and their application to regenerative medicine

• Project/Area Number: 23618007
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Regenerative medicine
• Research Institution: Osaka University
• Principal Investigator: MAEDA AKITO 大阪大学, 産学連携本部, 特任教授 (50298882)
• Co-Investigator(Renkei-kenkyūsha): FURUMOTO Tadashi 大阪大学, 産学連携本部, 特任助教授 (70594117)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 再生医学 / ｼｸﾞﾅﾙ伝達 / 細胞・組織 / シグナル伝達

Research Abstract

Previous studies have identified several small chemical compounds that activate the migration of mesenchymal stem cells. In present study, we analyzed the characteristics of stem cell migration by stimulation of the compounds. Furthermore, we examined the effect of migration activity and tissue regeneration of stem cells by compound stimulation in animal tissues. As a result, PL-C1 and PL-17 could enhance tissue regeneration in the skin wound model using diabetic mice, and could enhance the accumulation of stem cells with a compound applied in stem cell attraction model by skin wound. It is expected to be applied to a variety of tissue regeneration model using these compounds.

Research Products

• [Journal Article] Mallotus philippinensis derver components enhance the mobilization of mesenchymal stem cells for skin regeneration (2014)
  • Author(s): Furumoto T, Ozawa N, Inami Y, Toyoshima M, Fujita K, Zaiki K, Sahara S, Akita M, Kitamura K, Nakaoji K, Hamada K, Tamai K, Kaneda Y, Maeda A
  • Journal Title: Phytomedicine Volume: 21(3) Pages: 247-253
• [Journal Article] Mallotus philippinensis bark extracts promote preferential migration of mesenchymal stem cells and improve wound healing in mice. (2014)
  • Author(s): Furumoto T, Ozawa N, Inami Y, Toyoshima M, Fujita K, Zaiki K, Sahara S, Akita M, Kitamura K, Nakaoji K, Hamada K, Tamai K, Kaneda Y, Maeda A.
  • Journal Title: Phytomedicine. Volume: 21 Issue: 3 Pages: 247-253
  • DOI: 10.1016/j.phymed.2013.09.003
  • Peer Reviewed
• [Journal Article] HIG1, a novel regulator of mitochondrial y-secretase, maintains normal mitochondrial function (2012)
  • Author(s): Hayashi H, Nakagami H, Takeichi M, Shimamura M, Koibuchi N, Oiki E, Sato N, Koriyama H, Mori M, Gerardo Araujo R, Maeda A, Morishita R, Tamai K, Kaneda Y
  • Journal Title: The FASE Journal Volume: 26 (6) Pages: 2306-2317
• [Journal Article] Modification of a novel angiogenic peptide, AG30,for the development of novel therapeutic gents (2012)
  • Author(s): Nakagami H, Nishikawa T, Tamura N, Maeda A, Hibino H, Mochizuki M, Shimosato T, Moriya T, Morishita R,Tamai K, Tomono K, Kaneda Y
  • Journal Title: Journal of Cellular and Molecular Medicine Volume: 16 (7) Pages: 1629-1639
• [Journal Article] HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function. (2012)
  • Author(s): Hayashi H, Nakagami H, Takeichi M, Shimamura M, Koibuchi N, Oiki E, Sato N, Koriyama H, Mori M, Gerardo Araujo R,Maeda A, Morishita R, Tamai K, Kaneda Y.
  • Journal Title: The FASEB Journal. Volume: -
  • Peer Reviewed
• [Journal Article] Modification of a novel angiogenic peptide, AG30, for the development of novel therapeutic agents. (2011)
  • Author(s): Nakagami H, Nishikawa T, Tamura N, Maeda A, Hibino H, Mochizuki M, Shimosato T, Moriya T, Morishita R, Tamai K, Tomono K, Kaneda Y
  • Journal Title: J Cell Mol Med Volume: - Issue: 7 Pages: 1629-1639
  • DOI: 10.1111/j.1582-4934.2011.01406.x
  • Peer Reviewed
• [Presentation] クスノハガシワ含有成分による問葉系幹細胞の動員と皮膚創傷治癒の促進 (2014)
  • Author(s): 古元義、藤田浩祐、稲見雄太、豊島美咲、仲尾次浩一、濱田和彦、竹仲有希子、棚橋孝雄、前田明人
  • Organizer: 第134回日本薬学会年会
  • Place of Presentation: 熊本市総合体育館
  • Year and Date: 2014-03-28
• [Presentation] クスノハガシワ含有成分による問葉系幹細胞の集積と皮膚創傷の修復 (2014)
  • Author(s): 古元義、藤田浩祐、豊島美咲、財木香里、佐原俊矢、秋田茉里子、小澤範恭、仲尾次浩一、濱田和彦、前田明人
  • Organizer: 第13回日本再生医療学会年会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2014-03-04
• [Presentation] Mallotus philippinensis derived components enhance the mobilization of mesenchymal stem cells for skin regeneration (2013)
  • Author(s): Furumoto T, Fujita K, Toyoshima M, Zaiki K, Sahara S, Akita M, Ozawa N, Nakaoji K, Hamada K, Tamai K, Kaneda Y, Maeda A
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸国際展示場
  • Year and Date: 2013-12-05
• [Presentation] クスノハガシワ含有成分による間葉系幹細胞の動員と皮膚創傷治癒の促進 (2013)
  • Author(s): 古元義、稲見雄太、豊島美咲、財木香里、藤田浩祐、小澤範恭、仲尾次浩二、濱田和彦、前田明人
  • Organizer: 第12回日本再生医療学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2013-03-21
• [Presentation] Ingredint in Mallotus extract enhances the motility of mesenchymal stem cells to regenerate injuredskin (2012)
  • Author(s): Furumoto T, Inami Y, Toyoshima M, Zaiki K, Fujita K, Ozawa N, Nakaoji K, Hamada K, Maeda A
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2012-12-14
• [Presentation] Enhancement of the chemotactic activity of mesenchymal stem cells by components in Oenothera (2012)
  • Author(s): Kanda A, Furumoto T, Kanematu Y, Maeda A
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2012-12-14
• [Presentation] Characterization of natural compounds that enhances the migration of mesenchymal stem cells (2011)
  • Author(s): Furumoto T, Inami Y, Kitamura K, Toyoshima M, Fujita K, Ozawa N, Nakaoji K, Hamada K, Maeda A.
  • Organizer: 第34回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] Mallotus philippinensis derived components enhance the mobilization of mesenchymal stem cells for skin regeneration.
  • Author(s): Furumoto T, Fujita K, Toyoshima M, Zaiki K, Sahara S, Akita M, Ozawa N, Nakaoji K, Hamada K, Tamai K, Kaneda Y, Maeda A.
  • Organizer: 第３６回 日本分子生物学会年会
  • Place of Presentation: 神戸国際展示場(神戸市）
• [Presentation] クスノハガシワ含有成分による間葉系幹細胞の集積と皮膚創傷の修復
  • Author(s): 古元義、藤田浩祐、豊島美咲、財木香里、佐原俊矢、秋田茉里子、小澤範恭、仲尾次浩一、濱田和彦、前田明人
  • Organizer: 第１３回 日本再生医療学会年会
  • Place of Presentation: 国立京都国際会館（京都市）
• [Presentation] クスノハガシワ含有成分による間葉系幹細胞の動員と皮膚創傷治癒の促進
  • Author(s): 古元義、稲見雄太、藤田浩祐、豊島美咲、仲尾次浩一、濱田和彦、竹仲有希子、棚橋孝雄、前田明人
  • Organizer: 第１３４回 日本薬学会年会
  • Place of Presentation: 熊本市総合体育館（熊本市）
• [Presentation] Ingredient in Mallotus extract enhances the motility of mesenchymal stem cells to regenerate injured skin
  • Author(s): Tadashi Furumoto, Yuta Inami, Misaki Toyoshima, Kaori Zaiki, Kosuke Fujita, Noriyasu Ozawa, Koichi Nakaoji, Kazuhiko Hamada, Akito Maeda
  • Organizer: 第35回 日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場（福岡市）
• [Presentation] Enhancement of the chemotactic activity of mesenchymal stem cells by components in Oenothera
  • Author(s): Akiko Kanda, Tadashi Furumoto, Yasuo Kanematsu, Akito Maeda
  • Organizer: 第35回 日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場（福岡市）
• [Presentation] クスノハガシワ含有成分による間葉系幹細胞の動員と皮膚創傷治癒の促進
  • Author(s): 古元義、稲見雄太、豊島美咲、財木香里、藤田浩祐、小澤範恭、仲尾次浩一、濱田和彦、前田明人
  • Organizer: 第12回 日本再生医療学会年会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Remarks]
  • URL: http://pias-cr.casi.osaka-u.ac.jp
• [Patent(Industrial Property Rights)] 抗老化剤、抗老化用飲食品及び抗老化方法 (2014)
  • Inventor(s): 前田明人・その他
  • Industrial Property Rights Holder: 大阪大学・ピアス株式会社
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-02-06
  • Overseas
• [Patent(Industrial Property Rights)] 抗老化剤、抗老化用飲食品、及び抗老化方法 (2014)
  • Inventor(s): 前田明人
  • Industrial Property Rights Holder: 大阪大学 ピアス株式会社
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-021608
  • Filing Date: 2014-02-06
• [Patent(Industrial Property Rights)] 問葉系幹細胞を皮膚組織へ誘導する皮膚外用剤 (2012)
  • Inventor(s): 前田明人・その他
  • Industrial Property Rights Holder: 大阪大学・ピアス株式会社
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-06-21
  • Overseas
• [Patent(Industrial Property Rights)] 間葉系幹細胞を皮膚組織へ誘導する皮膚外用剤 (2012)
  • Inventor(s): 前田明人・その他
  • Industrial Property Rights Holder: 大阪大学・ピアス株式会社
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-06-21