Safety and effectiveness of neural stem cells directly induced from skin fibroblasts
| Project/Area Number |
23618010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Regenerative medicine
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| Research Institution | Keio University |
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Principal Investigator |
AKAMATSU WADO 慶應義塾大学, 医学部, 講師 (60338184)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 神経幹細胞 / ダイレクトリプログラミング / リプログラミング / 直接誘導 / iPS細胞 |
|---|
| Research Abstract |
We succeeded in making human directly induced neural stem cells by using Sendai virus vectors. Although we were able to obtain increased number of neurospheres compared to retroviral vectors, SeV-induced neurospheres did not differentiate into neural cells efficiently.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] Involvement of ER Stress in Dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 Missense Mutations Shown by iPSC-Derived Oligodendrocytes2014
Author(s)
Numasawa-Kuroiwa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, Nakanishi A, Oyama M, Oasaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H
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Journal Title
Stem Cell Rep
Volume: 2
Issue: 5
Pages: 1-14
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The RNA-binding protein HuD regulates autophagosome formation in pancreatic β cells by promoting autophagy-related gene 5 expression.2014
Author(s)
Kim C, Kim W, Lee H, Ji E, Choe YJ, Martindale JL, Akamatsu W, Okano H, Kim HS, Nam SW, Gorospe M, Lee EK.
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Journal Title
J Biol Chem.
Volume: 289
Issue: 1
Pages: 112-121
DOI
Related Report
Peer Reviewed
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[Journal Article] Increased l1 retrotransposition in the neuroral genome in schizophrenia.2014
Author(s)
Miki Bundo, Manabu Toyoshima, Yohei Okada, Wado Akamatsu, Junko Ueda, Taeko Nemoto-Miyauchi, Fumiko Sunaga, Michihiro Toritsuka, Daisuke Ikawa, Akiyoshi Kakita, Motoichiro Kato, Kiyoto Kasai, Toshifumi Kishimoto, Hiroyuki Nawa, Hideyuki Okano, Takeo Yoshikawa, Tadafumi Katoemail, Kazuya Iwamoto
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Journal Title
Neuron
Volume: 81
Issue: 2
Pages: 306-313
DOI
Related Report
Peer Reviewed
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[Journal Article] A human Dravet syndrome model from patient induced pluripotent stem cells.2013
Author(s)
Higurashi N, Uchida T, Lossin C, Misumi Y, Okada Y, Akamatsu W, Imaizumi Y, Zhang B, Nabeshima K, Mori MX, Katsurabayashi S, Shirasaka Y, Okano H, Hirose S.
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Journal Title
Mol Brain
Volume: 6
Issue: 1
Pages: 19-19
DOI
Related Report
Peer Reviewed
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[Journal Article] RNA-binding protein HuD controls insulin translation2012
Author(s)
Lee EK, Kim W, Tominaga K, Martindale JL, Yang X, Subaran SS, Carlson OD, Mercken EM, Kulkarni RN, Akamatsu W, Okano H, Perrone-Bizzozero NI, de Cabo R, Egan JM, Gorospe M
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Journal Title
Mol Cell
Volume: 45 (6)
Issue: 6
Pages: 826-35
DOI
Related Report
Peer Reviewed
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[Journal Article] RNA-Binding Protein HuD Controls Insulin Translation2012
Author(s)
Lee EK, Kim W, Tominaga K, Martindale JL, Yang X, Subaran SS, Carlson OD, Mercken EM, Kulkarni RN, Akamatsu W, Okano H, Perrone-Bizzozero NI, de Cabo R, Egan JM, Gorospe M.
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Journal Title
Molecular Cell
Volume: 45(6)
Pages: 826-35
Related Report
Peer Reviewed
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