| Project/Area Number |
23650158
|
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioinformatics/Life informatics
|
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| Research Institution | Doshisha University (2012)
Kyoto Sangyo University (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
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| Keywords | 海馬 / 場所細胞 / 細胞体 / 樹状突起 |
|---|
| Research Abstract |
Since hippocampal pyramidal neurons discharge specifically at a certain location in the environment, they are termed ‘place cell’. However, recent studies indicate that the place field can be changed in relation to where the animal had just been, where it is about to go next and what demand it currently faces. In the present study, conducting a multifaceted experiment in which many hippocampal neurons are simultaneously monitored during repeated exposures to either spatiotemporal or non-spatial contexts in a constant spatial environment, I succeeded to monitor the changes and dynamics of the hippocampal place code. As a result, I found that the location and firing rate within the place field represents the information for journey and task-demand, respectively. Moreover, all of the information can be simultaneously preserved in the hippocampal ensemble activity to form episodes
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