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Mechanism underlying photoreceptor degeneration in response to vesicular fusion defects

Research Project

Project/Area Number 23650173
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neuroscience in general
Research Institution沖縄科学技術大学院大学

Principal Investigator

MASAI Ichiro  沖縄科学技術大学院大学, 神経発生ユニット, 准教授 (50242087)

Co-Investigator(Renkei-kenkyūsha) NISHIWAKI Yuko  沖縄科学技術大学院, 神経発生ユニット, 研究員 (20360620)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords神経科学 / 脳神経疾患 / 視細胞変性 / 遺伝疾患 / アポトーシス / 小胞輸送 / ゼブラフィッシュ / BH3-only蛋白質 / 細胞死 / β-SNAP / BNip1 / BH3蛋白質
Research Abstract

There are hereditary photoreceptor degeneration diseases in human. While previous studies suggested a connection between defects in vesicular transport and photoreceptor degeneration, the mechanism behind this link remained elusive. In this study, we investigated the mechanism underlying photoreceptor degeneration using zebrafish and identified BNip1 as a factor that induces cell death in response to vesicular transport defects. This finding uncovers a novel mechanism of photoreceptor degeneration and may advance our understanding of pathological process of human genetic retinal disease.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (27 results)

All 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (24 results) Remarks (1 results)

  • [Journal Article] The BH3-only SNARE BNip1 mediates photoreceptor apoptosis in response to vesicular fusion defects2013

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
    • Journal Title

      Developmental Cell

      Volume: 25 Issue: 4 Pages: 374-387

    • DOI

      10.1016/j.devcel.2013.04.015

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] (*equal contribution; #corresponding authors) Ectopic expression of the cone-specific Gprotein-coupled receptor kinase GRK7 in zebrafish rods leads to decreased photosensitivity and compromised visual performance2011

    • Author(s)
      Vogalis,F., Shiraki,T., Kojima,D., Fukada,Y. & Lamb,T.
    • Journal Title

      J. Physiol. (London)

      Volume: 589 Issue: 9 Pages: 2321-2348

    • DOI

      10.1113/jphysiol.2010.204156

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Syntaxin18cis-SNARE complex is a novel alarm factorthat detects vesicular transport defects2013

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
    • Organizer
      The 46th Annual Meeting of the Japanese Society of Developmental Biologists.
    • Place of Presentation
      Matsue, Shimane Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Characterization of a zebrafish mutantshowing cone photoreceptor degeneration2013

    • Author(s)
      Iribarne, M., Nishiwaki, Y., and Masai, I.
    • Organizer
      The 46th Annual Meeting of the Japanese Society of Developmental Biologists Matsue,
    • Place of Presentation
      Shimane, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Syntaxin18 cis-SNARE complex is a novel alarm factor that detects vesicular transport defects2013

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
    • Organizer
      The 46th Annual Meeting of the Japanese Society of Developmental Biologists
    • Place of Presentation
      Matsue, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Characterization of a zebrafish mutant showing cone photoreceptor degeneration2013

    • Author(s)
      Iribarne, M., Nishiwaki, Y., and Masai, I.
    • Organizer
      The 46th Annual Meeting of the Japanese Society of Developmental Biologists
    • Place of Presentation
      Matsue, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Geneticmutation of beta-SNAP causes photoreceptordegeneration through the activation of theBH3-only SNARE, BNip12012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
    • Organizer
      10th International Conference Zebrafish Development and Genetics
    • Place of Presentation
      Madison, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Genetic mutation of beta-SNAP causes photoreceptor degeneration through the activation of the BH3-only SNARE, BNip12012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
    • Organizer
      APDBC Taiwan 2012 Asia-Pacific Developmental Biology Conference 2012
    • Place of Presentation
      Taipei Innovation City Convention Center, Taipei, Taiwan
    • Related Report
      2012 Final Research Report
  • [Presentation] The BH3-only SNARE of syntaxin18, BNip1, mediates photoreceptor apoptosis in response to vesicular fusion defects2012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
    • Organizer
      Gordon researchconference ? visual system development.
    • Place of Presentation
      Colby-Sawyer College, New London, NH
    • Related Report
      2012 Final Research Report
  • [Presentation] The BH3-onlySNARE of syntaxin18, BNip1, is a mediatorof photoreceptor apoptosis in response tovesicular fusion defects2012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
    • Organizer
      The 35th annual meeting of the Molecular Biology Society
    • Place of Presentation
      Japan. Fukuoka
    • Related Report
      2012 Final Research Report
  • [Presentation] Genetic mutation of beta-SNAP causes photoreceptor degeneration through the activation of the BH3-only SNARE,BNip12012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
    • Organizer
      The 18th Japanese Medaka and zebrafish meeting.
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] The BH3-onlySNARE of syntaxin18, BNip1, is a mediatorof photoreceptor apoptosis in response tovesicular fusion defects2012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
    • Organizer
      Neuroscience 2012.The 35thannual meeting of the JapanNeuroscience Society.
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Geneticmutation of beta-SNAP causesphotoreceptor degeneration through theactivation of the BH3-only SNARE, BNip12012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
    • Organizer
      Joint meeting of the 45th annual meeting of the Japanese society of DevelopmentalBiologists & the 64thannual meeting of theJapanese society of Cell Biology.
    • Place of Presentation
      Kobe,Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Genetic mutation of beta-SNAP causes photoreceptor degeneration through the activation of the BH3-only SNARE, BNip12012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
    • Organizer
      10th International Conference Zebrafish Development and Genetics
    • Place of Presentation
      Madison, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Genetic mutation of beta-SNAP causes photoreceptor degeneration through the activation of the BH3-only SNARE, BNip12012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
    • Organizer
      APDBC Taiwan 2012 Asia-Pacific Developmental Biology Conference 2012
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2012 Annual Research Report
  • [Presentation] The BH3-only SNARE of syntaxin18, BNip1, mediates photoreceptor apoptosis in response to vesicular fusion defects2012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
    • Organizer
      Gordon research conference visual system development
    • Place of Presentation
      New London, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] The BH3-only SNARE of syntaxin18, BNip1, is a mediator of photoreceptor apoptosis in response to vesicular fusion defects2012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
    • Organizer
      The 35th annual meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Genetic mutation of beta-SNAP causes photoreceptor degeneration through the activation of the BH3-only SNARE, BNip12012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
    • Organizer
      The 18th Japanese Medaka and zebrafish meeting
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] The BH3-only SNARE of syntaxin18, BNip1, is a mediator of photoreceptor apoptosis in response to vesicular fusion defects2012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
    • Organizer
      The 35th annual meeting of the Japan Neuroscience Society
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Genetic mutation of beta-SNAP causes photoreceptor degeneration through the activation of the BH3-only SNARE, BNip12012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
    • Organizer
      Joint meeting of the 45th annual meeting of the Japanese society of Developmental Biologists & the 64th annual meeting of the Japanese society of Cell Biology
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Molecular mechanism that transforms defects in intracellular vesicular transport into apoptosis in zebrafishphotoreceptors2011

    • Author(s)
      Masai, I.
    • Organizer
      5th Asia-Oceania zebrafish international meeting, China National Convention Center
    • Place of Presentation
      Beijing, China
    • Related Report
      2012 Final Research Report
  • [Presentation] Mutation of beta-SNAP induces amitochondria-dependent apoptosis inzebrafish photoreceptors2011

    • Author(s)
      Nishiwaki, Y., Suzuki, S., Yoshizawa, A.,Kojima, Y., Mochizuki, T., Masai, I.
    • Organizer
      7th EuropeanZebrafish Meeting
    • Place of Presentation
      Edinburgh, Scotland
    • Related Report
      2012 Final Research Report
  • [Presentation] Azebrafish corona mutation induces aBcl2-dependent apoptosis in photoreceptor2011

    • Author(s)
      Nishiwaki, Y., Suzuki, S., Yoshizawa, A.,Kojima, Y., Mochizuki, T., Masai, I.
    • Organizer
      44th Annual Meeting of the Japanese Society of Developmental Biologists
    • Place of Presentation
      Okinawa Convention Center (Ginowan City)
    • Related Report
      2012 Final Research Report
  • [Presentation] Molecular mechanism that transforms defects in intracellular vesicular transport into apoptosis in zebrafish photoreceptors2011

    • Author(s)
      政井一郎
    • Organizer
      第5回 アジアオセアニア ゼブラフィッシュ国際会議
    • Place of Presentation
      北京、中国
    • Related Report
      2011 Research-status Report
  • [Presentation] A zebrafish corona mutation induces a Bcl2-dependent apoptosis in photoreceptor2011

    • Author(s)
      西脇優子、鈴木祥平、吉澤あすか、小島豊、望月俊昭、政井一郎
    • Organizer
      第44回 日本発生生物学会年会
    • Place of Presentation
      沖縄、日本
    • Related Report
      2011 Research-status Report
  • [Presentation] Mutation of beta-SNAP induces a mitochondria-dependent apoptosis in zebrafish photoreceptors2011

    • Author(s)
      西脇優子、鈴木祥平、吉澤あすか、小島豊、望月俊昭、政井一郎
    • Organizer
      第7回 ヨーロッパ ゼブラフィッシュ国際会議
    • Place of Presentation
      エジンバラ、英国
    • Related Report
      2011 Research-status Report
  • [Remarks] 目の見えないゼブラフィッシュがヒトの網膜疾患治療に光をもたらす

    • URL

      http://www.oist.jp/ja/news-center/press-releases/10744

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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