| Project/Area Number |
23650187
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HAYASHI Takashi 東京大学, 大学院・医学系研究科, 助教 (80547472)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 神経伝達物質 / グルタミン酸 / 受容体 / 翻訳後修飾 / シナプス形成 |
|---|
| Research Abstract |
In the ionotropic glutamate receptors (iGluRs), post-translational protein modifications of AMPA receptors and NMDA receptors modulate these receptor ion channel properties as well as the membrane trafficking of receptors to/from the post-synapses. Through this program, we focused on palmitoylation-dependent regulation of iGluR function. Our findings revealed novel roles of palmitoylation of AMPA receptor-binding protein GRIP1, which regulates dynamic trafficking of AMPA receptors in cortical and hippocampal neurons. In addition, we showed that synaptic delivery of NMDA receptors is controlled by their dual palmitoylation in hippocampal CA1 pyramidal neurons.
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