Visualization and molecular mechanisms underlying neural polarity protein SAD kinase-mediated phosphorylation
| Project/Area Number |
23650188
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
OHTSUKA Toshihisa 山梨大学, 大学院・医学工学総合研究部, 教授 (40401806)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 細胞内情報伝達 / シナプス / リン酸化 / アクティブゾーン |
|---|
| Research Abstract |
SAD kinase, a serine/threonine kinase associated with synapticvesicles and active zones in the nerve terminals, has shown to phosphorylate an active zone protein specifically. An anti-phospho antibody against thephosphorylated sequence was produced and su
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Deletion of the presynaptic scaffold CAST reduces active zone size in rod photoreceptors and impairs visual processing2012
Author(s)
tom Dieck, S., Specht, D., Strenzke, N., Hida, Y., Krishnamoorthy, V., Inoue, E., Ishizaki, H., Tanaka-Okamoto, M., Miyoshi, J., Hagiwara, A., Brandstatter, JH., Gollisch, T., Ohtsuka, T. *, Moser, T*
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Journal Title
J. Neurosci
Volume: 32
Pages: 12192-12203
Related Report
Peer Reviewed
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[Journal Article] Physical and Functional Interaction of the Active Zone Protein CAST/ERC2 and the ss-subunit of the Voltage-dependent Ca^Channel2012
Author(s)
Kiyonaka, S., Nakajima, H., Takada, Y., Hida, Y., Yoshioka, T., Hagiwara, A., Kitajima, I., Mori, Y., Ohtsuka, T
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Journal Title
J. Biochem
Volume: 152
Pages: 149-159
Related Report
Peer Reviewed
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