| Project/Area Number |
23650193
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAOKA Hitoshi 北里大学, 医学部, 教授 (40209862)
ITAKURA Makoto 北里大学, 医学部, 講師 (30398581)
AZUMA Sadahiro 北里大学, 医学部, 助教 (80348507)
YAMAMORI Saori 北里大学, 医学部, 助教 (30464803)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | SNAP-25 / ピロカルピン / てんかん / 不安様行動 / モノアミン / BDNF / ストレス / 不安障害 / モデルマウス / 活性化アストロサイト |
|---|
| Research Abstract |
Neuronal mechanism of anxiety behavior observed after having repeated epileptic seizures are investigated using two mouse models. Catecholamine was not involved, but some changes in brain structure that appear within three days after repeated epileptic seizures are responsible for the development of anxiety-related behavior. From immunoblot analysis of brain homogenate, expression of BDNF was paralleled with the expression of anxiety behavior.
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