| Project/Area Number |
23650250
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kawasaki University of Medical Welfare (2012)
Tohoku University (2011) |
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Principal Investigator |
SAKAMOTO Naoya 川崎医療福祉大学, 医療技術学部, 准教授 (20361115)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | バイオメカニクス / 生物生体工学 / 細胞核 / 細胞骨格 / 架橋タンパク質 / 細胞 内力学伝達 / 生物・生体工学 / 細胞内力学伝達 |
|---|
| Research Abstract |
In this study, the author investigated the mechanical role of nesprin, a component of linker of nucleus and cytoskeleton (LINC) in force transmission from actin filaments to the nucleus. Results showed that force transmission between actin filaments and nuclei via nesprin is required for stretch-induced morphological response of endothelial cells, suggesting that nuclei play an important role in mechano-sensing of cells.
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