Design of apoptotic cell membrane mimetic smart polymers for treatment of acute heart failure
| Project/Area Number |
23650295
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | National Institute for Materials Science |
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Principal Investigator |
EBARA Mitsuhiro 独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA研究者 (10452393)
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| Co-Investigator(Kenkyū-buntansha) |
青柳 隆夫 独立行政法人物質・材料研究機構, その他部局等, その他 (40277132)
齋藤 充弘 大阪大学, 医学部附属病院, 講師 (20448038)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | バイオマテリアル / 炎症細胞 / スマート材料 / 急性疾患 / アポトーシス / スマートポリマー |
|---|
| Research Abstract |
We newly synthesized monomers with phosphatidylserine (PS) group to examine the potential ability of apoptotic cell-mimetic polymers as an alternative tool for anti-inflammatory therapy. We polymerized monomer, and evaluated physical properties and anti-inflammatory activity of the obtained polymer. Increased secretion of anti-inflammatory cytokines from macrophages was observed when exposed to PS-polymers.
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Report
(4 results)
Research Products
(79 results)
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[Journal Article] Hippo Pathway Effectors Control Cardiac Progenitor Cell Fate by Acting as Dynamic Sensors of Substrate Mechanics and Nanostructure2014
Author(s)
Diogo Mosqueira, Stefania Pagliari, Koichiro Uto, Mitsuhiro Ebara, Sara Romanazzo, Carmen Escobedo-Lucea , Jun Nakanishi, Akiyoshi Taniguchi, Ornella Franzese, Paolo Di Nardo, Marie José Goumans, Enrico Traversa , Perpetua Pinto-do-Ó, Takao Aoyagi, and Giancarlo Forte
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Journal Title
ACS Nano
Volume: 8
Issue: 3
Pages: 2033-2047
DOI
Related Report
Peer Reviewed
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