Design of apoptotic cell membrane mimetic smart polymers for treatment of acute heart failure

• Project/Area Number: 23650295
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biological material science
• Research Institution: National Institute for Materials Science
• Principal Investigator: EBARA Mitsuhiro 独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA研究者 (10452393)
• Co-Investigator(Kenkyū-buntansha): 青柳 隆夫 独立行政法人物質・材料研究機構, その他部局等, その他 (40277132) ; 齋藤 充弘 大阪大学, 医学部附属病院, 講師 (20448038)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: バイオマテリアル / 炎症細胞 / スマート材料 / 急性疾患 / アポトーシス / スマートポリマー

Research Abstract

We newly synthesized monomers with phosphatidylserine (PS) group to examine the potential ability of apoptotic cell-mimetic polymers as an alternative tool for anti-inflammatory therapy. We polymerized monomer, and evaluated physical properties and anti-inflammatory activity of the obtained polymer. Increased secretion of anti-inflammatory cytokines from macrophages was observed when exposed to PS-polymers.

Research Products

• [Journal Article] Hippo Pathway Effectors Control Cardiac Progenitor Cell Fate by Acting as Dynamic Sensors of Substrate Mechanics and Nanostructure (2014)
  • Author(s): Diogo Mosqueira, Stefania Pagliari, Koichiro Uto, Mitsuhiro Ebara, Sara Romanazzo, Carmen Escobedo-Lucea , Jun Nakanishi, Akiyoshi Taniguchi, Ornella Franzese, Paolo Di Nardo, Marie José Goumans, Enrico Traversa , Perpetua Pinto-do-Ó, Takao Aoyagi, and Giancarlo Forte
  • Journal Title: ACS Nano Volume: 8 Issue: 3 Pages: 2033-2047
  • DOI: 10.1021/nn4058984
  • Peer Reviewed
• [Journal Article] Temperature-responsive poly(e-caprolactone) cell culture platform with reversibly tunable nano-roughness and elasticity for control of myoblast morphology (2014)
  • Author(s): K . Uto, M . Ebara, T. Aoyagi
  • Journal Title: International Journal of Molecular Science Volume: 15 Issue: 1 Pages: 1511-1524
  • DOI: 10.3390/ijms15011511
  • Peer Reviewed / Open Access
• [Journal Article] The taming of the cell : shape-memory nanopatterns direct cell orientation (2014)
  • Author(s): M . Ebara, K. Uto, N. Idota, T. Aoyagi
  • Journal Title: International Journal of Nanomedicine Volume: 9 Pages: 117-126
  • DOI: 10.2147/ijn.s50677
  • Peer Reviewed / Open Access
• [Journal Article] Design of Smart Nanogels that Respond to Physiologically Relevant pH Values and Temperatures (2014)
  • Author(s): Tomoyuki Omura, Mitsuhiro Ebara, James J. Lai, Xiangchun Yin, Allan S. Hoffman, and Patrick S. Stayton
  • Journal Title: Journal of Nanoscience and Nanotechnology Volume: 14 Issue: 3 Pages: 2557-2562
  • DOI: 10.1166/jnn.2014.8551
  • Peer Reviewed / Open Access
• [Journal Article] A Smart Hyperthermia Nanofiber with Switchable Drug Release for Inducing Cancer Apoptosis (2013)
  • Author(s): Y.-J. Kim, M . Ebara, T. Aoyagi
  • Journal Title: Advanced Functional Materials Volume: 23 Issue: 46 Pages: 5753-5761
  • DOI: 10.1002/adfm.201300746
  • Peer Reviewed
• [Journal Article] A photo-induced nanoparticle separation in microchannels via pH-sensitive surface traps (2013)
  • Author(s): M. Ebara, J. M. Hoffman, A. S. Hoffman, P. S. Stayton, J. J. Lai
  • Journal Title: Langmuir Volume: 29 Issue: 18 Pages: 5388-5393
  • DOI: 10.1021/la400347r
  • Peer Reviewed
• [Journal Article] Nano-decoration of Hemagglutinating Virus of Japan Envelope (HVJ-E) Using Layer-by-Layer Assembly Technique (2013)
  • Author(s): Takaharu Okada, Koichiro Uto, Masao Sasai, Chun Man Lee, Mitsuhiro Ebara, Takao Aoyagi
  • Journal Title: Langmuir Volume: 29 Issue: 24 Pages: 7384-7392
  • DOI: 10.1021/la304572s
  • Peer Reviewed
• [Journal Article] Fabrication of FITC-doped silica nanoparticles and study of their cellular uptake in the presence of lectins (2013)
  • Author(s): Yohei Kotsuchibashia, Yiyao Zhang, Marya Ahmed, Mitsuhiro Ebara, Takao Aoyagi, Ravin Narain
  • Journal Title: Journal of Biomedical Materials Research: Part A Volume: 101A Issue: 7 Pages: 2090-2096
  • DOI: 10.1002/jbm.a.34498
  • Peer Reviewed
• [Journal Article] 免疫反応を制御可能な未来型バイオマテリアルの設計―Immunobioengineering (2013)
  • Author(s): 荏原充宏
  • Journal Title: Drug Delivery System Volume: 28-2 Pages: 135-148
  • NAID: 130003368341
• [Journal Article] Shape-Memory Surface with Dynamically Tunable Nano-Geometry Activated by Body Heat (2012)
  • Author(s): Mitsuhiro Ebara, Koichiro Uto, Naokazu Idota, John M.Hoffman, Takao Aoyagi
  • Journal Title: Advanced Materials Volume: 24 Issue: 2 Pages: 273-278
  • DOI: 10.1002/adma.201102181
  • Peer Reviewed
• [Journal Article] A smart nanofiber web that captures and release cells (2012)
  • Author(s): Y.-J. Kim, M. Ebara, T. Aoyagi
  • Journal Title: Angewandte Chemie International Edition Volume: 51 Issue: 42 Pages: 10537-10541
  • DOI: 10.1002/anie.201204139
  • Peer Reviewed
• [Journal Article] Photo-switchable control of pH-responsive actuators via pH jump reaction (2012)
  • Author(s): Prapatsorn Techawanitchai, Mitsuhiro Ebara, Naokazu Idota, Taka-Aki Asoh, Akihiko Kikuchi, Takao Aoyagi
  • Journal Title: Soft Matter Volume: 8 Issue: 10 Pages: 2844-2851
  • DOI: 10.1039/c2sm07277g
  • Peer Reviewed
• [Journal Article] Light-induced spatial control of pH-jump reaction at smart gel interface (2012)
  • Author(s): Prapatsorn Techawanitchai, Mitsuhiro Ebara, Naokazu Idota, Takao Aoyagi
  • Journal Title: Colloids and Surfaces B : Biointerfaces Volume: (in press) Pages: 53-59
  • DOI: 10.1016/j.colsurfb.2011.09.039
  • Peer Reviewed
• [Journal Article] Fabrication of dual-responsive polymer functionalized silica nanoparticles via a simple thiol-ene click chemistry (2012)
  • Author(s): Y. Kotsuchibashi, M. Ebara, T. Aoyagi, R. Narain
  • Journal Title: Polymer Chemistry Volume: 3 Issue: 9 Pages: 2545-2550
  • DOI: 10.1039/c2py20333b
  • Peer Reviewed
• [Journal Article] A Smart Hydrogel-based Time Bomb Triggers Drug Release Mediated by pH-jump Reaction (2012)
  • Author(s): Prapatsorn Techawanitcha, Naokazu Idota, Mitsuhiro Ebara, Takao Aoyagi
  • Journal Title: Science and Technology of Advanced Materials Volume: 13 Issue: 6 Pages: 64202-64202
  • DOI: 10.1088/1468-6996/13/6/064202
  • Peer Reviewed
• [Journal Article] Temperature-responsive electrospun nanofibers for "on-off" switchable release of dextran (2012)
  • Author(s): Young-Jin Kim
  • Journal Title: Science and Technology of Advanced Materials Volume: 13 Issue: 6 Pages: 64203-64203
  • DOI: 10.1088/1468-6996/13/6/064203
  • Peer Reviewed
• [Journal Article] Fabrication of FITC-doped silica nanoparticles and study of their ceullar uptake in the presence of lectins (2012)
  • Author(s): Y. Kotsuchibashi, Y. Zhang, M. Ahmed, M. Ebara, T. Aoyagi, R. Narain
  • Journal Title: Journal of Biomedical Materials Research Volume: Part A Issue: 6 Pages: 64207-64207
  • DOI: 10.1088/1468-6996/13/6/064207
  • Peer Reviewed
• [Journal Article] Novel Temperature-Responsive Polymer Brushes with Carbohydrate Residues Facilitate Selective Adhesion and Collection of Hepatocytes (2012)
  • Author(s): Naokazu Idota, Mitsuhiro Ebara, Yohei Kotsuchibashi, Ravin Narain, Takao Aoyagi
  • Journal Title: Science and Technology of Advanced Materials Volume: 13 Issue: 6 Pages: 64206-64206
  • DOI: 10.1088/1468-6996/13/6/064206
  • Peer Reviewed
• [Journal Article] A 'smart' approach towards the formation of multifunctional nano-assemblies by simple mixing of block copolymers having a common temperature sensitive segment (2012)
  • Author(s): Yohei Kotsuchibashi, Mitsuhiro Ebara, Naokazu Idota, Ravin Narain, Takao
  • Journal Title: Polymer Chemistry Volume: (in press) Issue: 5 Pages: 1150-1157
  • DOI: 10.1039/c2py00589a
  • Peer Reviewed
• [Journal Article] Substrate stiffness affects skeletal myoblasts differentiation in vitro (2012)
  • Author(s): Romanazzo S
  • Journal Title: Science and Technology of Advanced Materials Volume: 13 Issue: 6 Pages: 64211-64211
  • DOI: 10.1088/1468-6996/13/6/064211
  • Peer Reviewed
• [Journal Article] Mesenchymal stem cell adhesion but not plasticity is affected by high substrate stiffness. (2012)
  • Author(s): Tam KV
  • Journal Title: Science and Technology of Advanced Materials Volume: 13 Issue: 6 Pages: 64205-64205
  • DOI: 10.1088/1468-6996/13/6/064205
  • Peer Reviewed
• [Journal Article] スマートバイオマテリアルの応用 (2012)
  • Author(s): 荏原充宏, 青柳隆夫
  • Journal Title: ケミカルエンジニヤリング Volume: 57 Pages: 31-36
• [Journal Article] Supramolecular approaches for drug development (2012)
  • Author(s): Kohsaku Kawakami, Mitsuhiro Ebara, Hironori Izawa, Noelia M. Sanchez-Ballester, Jonathan P. Hill, and Katsuhiko Ariga
  • Journal Title: Current Medicinal Chemistry Volume: 19 Pages: 2388-2398
  • Peer Reviewed
• [Journal Article] スマートゲル表面’ 特集スマートゲルの最新動向 (2012)
  • Author(s): 荏原充宏
  • Journal Title: 機能材料 Volume: 32 Pages: 6-12
  • NAID: 40019194956
• [Journal Article] Effect of grafted smart polymer architectures on interaction with hydrophobic molecules in newly developed induction heating chromatography system (2011)
  • Author(s): Hisashi Yagi, Mitsuhiro Ebara, Kazuya Yamamoto, Takao Aoyagi
  • Journal Title: Materials Science and Engineering C Volume: 31 Issue: 8 Pages: 1681-1687
  • DOI: 10.1016/j.msec.2011.07.018
  • Peer Reviewed
• [Journal Article] Surface design with self-heating smart polymers for on-off switchable trap (2011)
  • Author(s): P.Techawanitchai
  • Journal Title: Science and Technology of Advanced Materials Volume: 12 Issue: 4 Pages: 44-609
  • DOI: 10.1088/1468-6996/12/4/044609
  • Peer Reviewed
• [Journal Article] Tunable stimuli-responsive self-assembly system that forms and stabilizes nanoparticles by simple mixing and heating/cooling of selected block copolymers (2011)
  • Author(s): Y. Kotsuchibashi, M. Ebara, K. Yamamoto, T. Aoyagi
  • Journal Title: Polymer Chemistry Volume: 2 Issue: 6 Pages: 1362-1367
  • DOI: 10.1039/c1py00004g
  • Peer Reviewed
• [Journal Article] 形状記憶インターフェイスを用いた細胞運命の時間・空間操作 (2011)
  • Author(s): 荏原充宏
  • Journal Title: Colloid & Interface Communication Volume: 36 Pages: 23-24
• [Presentation] アポトーシス細胞膜表面構造を模倣したホスホリルセリン基含有高分子の合成と評価 (2014)
  • Author(s): 中川泰宏, 斎藤充弘, 荏原充宏, 青柳隆夫
  • Organizer: つくば医工連携フォーラム2014
  • Place of Presentation: つくば
  • Year and Date: 2014-01-28
• [Presentation] アポトーシス細胞膜表面構造を模倣したホスホリルセリン基含有高分子の合成と評価 (2014)
  • Author(s): 中川泰宏, 斎藤充弘, 荏原充宏, 青柳隆夫
  • Organizer: 第63回高分子学会年次大会
  • Place of Presentation: 名古屋
• [Presentation] Synthesis and Characterization of Phosphoryl Serine-derived Temperature-responsive Polymers for Anti-inflammatory Therapy (2014)
  • Author(s): Y. Nakagawa, A. Saito, M. Ebara, T. Aoyagi
  • Organizer: International Symposium on Smart Biomaterials
  • Place of Presentation: Tsukuba
• [Presentation] Synthesis and Characterization of Phosphoryl Serine-derived Temperature-responsive Polymers for Anti-inflammatory Therapy (2014)
  • Author(s): Y. Nakagawa, A. Saito, M. Ebara, T. Aoyagi
  • Organizer: MANA Sympoisium 2014
  • Place of Presentation: Tsukuba
• [Presentation] スマートポリマーを用いた途上国医療への取り組み (2014)
  • Author(s): 荏原充宏
  • Organizer: 第18回関西大学先端科学技術シンポジウム
  • Place of Presentation: 関西大学
  • Invited
• [Presentation] Smart nanofibers for "on-off" switchable release of cell/drug (2013)
  • Author(s): Y. Kim, M. Ebara, T. Aoyagi
  • Organizer: つくば医工連携フォーラム 2013 医工連携の Hub 化~つくば
  • Place of Presentation: つくば
  • Year and Date: 2013-01-29
• [Presentation] アポトーシス細胞の細胞膜表面を模倣した炎症制御能を有する新規材料の開発 (2013)
  • Author(s): 中川泰宏, 斎藤充弘, 荏原充宏, 青柳隆夫
  • Organizer: 第35回日本バイオマテリアル学会大会
  • Place of Presentation: 東京
• [Presentation] 自己発熱に応答して薬物を放出するハイパーサーミアナノファイバーの作製 (2013)
  • Author(s): 荏原充宏, 金榮鎭, 青柳隆夫
  • Organizer: 第62回高分子学会年次大会
  • Place of Presentation: 京都
• [Presentation] Smart Nanofiber Webs for "On-off" Release of Cells and Drugs (2013)
  • Author(s): M. Ebara, Y. Kim, T. Aoyagi
  • Organizer: 2013 Annual Meeting of the Society For Biomaterials
  • Place of Presentation: Boston, USA
• [Presentation] A Smart Hyperthermia Nanofiber with Controlled Drug Release for Improved Cancer Therapy (2013)
  • Author(s): Y. Kim, M. Ebara, T. Aoyagi
  • Organizer: 2nd International Conference on Biomaterials Science in Tsukuba
  • Place of Presentation: Japan
• [Presentation] On-demand Encapsulation and Release of Cells using On-off Switchable Fibrous Hydrogels (2013)
  • Author(s): 金榮鎭 , 荏原充宏 , 青柳隆夫
  • Organizer: 第24回高分子ゲル研究討論会
  • Place of Presentation: 東京
• [Presentation] Smart on-off switchable surfaces with carbohydrate residues for selective adhesion and collection of cells (2013)
  • Author(s): Mitsuhiro Ebara
  • Organizer: 246th ACS National Meeting and Exposition
  • Place of Presentation: Indianapolis, USA
  • Invited
• [Presentation] 温熱療法と化学療法を同時に実現する温度応答性ナノファイバーメッシュの開発 (2013)
  • Author(s): 荏原 充宏, Young-Jin Kim, 青柳隆夫
  • Organizer: 第35回日本バイオマテリアル学会
  • Place of Presentation: タワーホール船堀
• [Presentation] Synthesis and Characterization of Apoptotic Cell Membrane-mimetic Materials Using Phosphoryl Serine (2013)
  • Author(s): Yasuhiro Nakagawa, Atsuhiro Saito, Mitsuhiro Ebara, Takao Aoyagi
  • Organizer: 第35回日本バイオマテリアル学会
  • Place of Presentation: タワーホール船堀
• [Presentation] 生体温度およびpHに応答するナノゲルの作製と評価 (2013)
  • Author(s): 大村朋幸, 荏原充宏, Allan S. Hoffman, Patrick S. Stayton
  • Organizer: 第35回日本バイオマテリアル学会
  • Place of Presentation: タワーホール船堀
• [Presentation] Smart surfaces with ‘on-off ’ switchable wettability, topography, and stiffness for control of cell functions (2013)
  • Author(s): Mitsuhiro Ebara
  • Organizer: International Workshop on Functional Polymer Surface and Interface
  • Place of Presentation: Kanazawa
  • Invited
• [Presentation] 温度応答性ナノファイバーを用いた薬物の"On-Off"放出制御 (2012)
  • Author(s): 金榮鎭, 荏原充宏, 青柳隆夫
  • Organizer: 日本バイオマテリアル学会シンポジウム2012
  • Place of Presentation: 仙台
• [Presentation] Smart Biomaterials Design for Nano-biotechnology (2012)
  • Author(s): T. Aoyagi, Y. Kim, M. Ebara
  • Organizer: 6th International Workshop on Advanced Materials Science
  • Place of Presentation: Ha Long City, Vietnam
• [Presentation] A New Class of Smart Fibrous-Hydrogel that Cell Capture and Release (2012)
  • Author(s): Y. Kim, M. Ebara, T. Aoyagi
  • Organizer: 7th International Symposium on Stimuli-Responsive Materials
  • Place of Presentation: Santa Rosa, USA
• [Presentation] Thermo-crosslinkable and temperature-responsive fibrous hydrogel via electrospinning for " on-off " controlled dextran release (2012)
  • Author(s): Y. Kim, M. Ebara, T. Aoyagi
  • Organizer: ゲルワークショップイン名古屋
• [Presentation] Photo-crosslinkable and Thermo-Responsive Nanofiber Webs for 'On-Off' Switches of Cell Capture/Release (2012)
  • Author(s): Y. Kim, M. Ebara, T. Aoyagi
  • Organizer: NanoBio Seattle2012
  • Place of Presentation: Seattle, USA
• [Presentation] “スマート”バイオマテリアルの開発 (2012)
  • Author(s): 荏原充宏
  • Organizer: 高分子同友会勉強会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 形状記憶表面を用いた細胞の体力測定 (2012)
  • Author(s): 荏原充宏
  • Organizer: 九州地区高分子若手研究
  • Place of Presentation: 小倉
  • Invited
• [Presentation] "Smart" shape-memory surfaces with tunable geometry for on-demand control of cell alignment (2012)
  • Author(s): Mitsuhiro Ebara
  • Organizer: NanoBio Seattle
  • Place of Presentation: Seattle
  • Invited
• [Presentation] Design of smart polymer conjugates with peptides and saccharides that provide on-off switches to surface capture/release of cells (2012)
  • Author(s): Mitsuhiro Ebara
  • Organizer: 241st ACS National Meeting
  • Place of Presentation: San Diego
• [Presentation] "Smart" Shape-Memory Surfaces for Mechano-Structural Control of Cell Functions (2012)
  • Author(s): Mitsuhiro Ebara, Koichiro Uto, Naokazu Idota, John M. Hoffman, Takao Aoyagi
  • Organizer: SIMS2012
  • Place of Presentation: つくば
• [Presentation] 状記憶を用いた書き換え可能なナノパターンの設計 (2011)
  • Author(s): 荏原充宏, 宇都甲一郎, 井戸田直和, 青柳隆夫
  • Organizer: 第60回高分子討論会
  • Place of Presentation: 岡山
• [Presentation] Design of saccharide-bearing smart polymer surfaces and micelles that provide on-off switches to surface capture/release (2011)
  • Author(s): Mitsuhiro Ebara
  • Organizer: 7th National Carbohydrate Symposium(招待講演)
  • Place of Presentation: Banff
• [Book] " Chapter 14 Cell-Based Bioconjugates. " Chemistry of Bioconjugates: Synthesis, Characterization, and Biomedical Applications, Edited by R. Narain, Wiley (2014)
  • Author(s): M. Ebara
• [Book] " Chapter 12 Silica Nanoparticle Bioconjugates. " Chemistry of Bioconjugates: Synthesis, Characterization, and Biomedical Applications, Edited by R. Narain, Wiley (2014)
  • Author(s): Y . Kotsuchibashi, M. Ebara, R. Narain
• [Book] 生体分子・高分子を用いたバイオマテリアルの開発~細胞と化学の狭間に秘められた可能性~' (2014)
  • Author(s): 蟹江慧, 荏原充宏, 加藤竜司
  • Publisher: 化学
• [Book] Chapter 14 Cell-Based Bioconjugates.” Chemistry of Bioconjugates: Synthesis, Characterization, and Biomedical Applications, Edited by R. Narain (2014)
  • Author(s): Mitsuhiro Ebara
  • Total Pages: 13
  • Publisher: Wiley
• [Book] Chapter 12 Silica Nanoparticle Bioconjugates.” Chemistry of Bioconjugates: Synthesis, Characterization, and Biomedical Applications, Edited by R. Narain (2014)
  • Author(s): Yohei Kotsuchibashi, Mitsuhiro Ebara, Ravin Narain
  • Total Pages: 17
  • Publisher: Wiley
• [Book] “貼るがん治療”～抗がん活性を有するナノファイバーメッシュの開発～ (2014)
  • Author(s): 荏原充宏
  • Total Pages: 4
  • Publisher: Nonwoven Review
• [Book] Toward the generation of patient-specific patches for cardiac repair . (2013)
  • Author(s): G. Forte, S. Pagliari, F . Pagliari, M. Ebara, P . D. Nardo, T . Aoyagi
  • Publisher: Stem Cell Reviews and Reports
• [Book] '生分解性高分子' 再生医療叢書 2 組織工学, 岡野光夫, 大和雅之編集 (2013)
  • Author(s): 荏原充宏, 宇都甲一郎, 青柳隆夫
  • Publisher: 朝倉書店
• [Book] '免疫反応を制御可能な未来型バイオマテリアルの設計 - Immunobioengineering'- Drug Delivery System (2013)
  • Author(s): 荏原充宏, 齋藤充弘
  • Publisher: 日本DDS学会
• [Book] 基材の構造力学的性質による細胞機能の制御' 特集 細胞接着の制御, 生体の科学 (2013)
  • Author(s): 荏原充宏, 宇都甲一郎, 青柳隆夫
• [Book] 生分解性プラスチックを活用した形状記憶高分子の開発 (2013)
  • Author(s): 荏原充宏
  • Total Pages: 4
  • Publisher: 月刊Polyfile
• [Book] 免疫反応を制御可能な未来型バイオマテリアルの設計―Immunobioengineering (2013)
  • Author(s): 荏原充宏, 齋藤充弘
  • Total Pages: 5
  • Publisher: Drug Delivery System
• [Book] Chapter 10 Nanotechnology in Drug Delivery Systems (2012)
  • Author(s): Kohsaku Kawakami and Mitsuhiro Ebara
  • Publisher: Manipulation of Nanoscale Materials
• [Book] 'スマートバイオマテリアルの応用'- ケミカルエンジニヤリング (2012)
  • Author(s): 荏原充宏, 青柳隆夫
  • Publisher: 化学工業社
• [Book] Supramolecular approaches for drug development (2012)
  • Author(s): K. Kawakami, M. Ebara, H. Izawa, N. M. Sanchez-Ballester , J. P . Hill, and K. Ariga
  • Publisher: Current Medicinal Chemistry
• [Book] 'スマートゲル表面' 特集スマートゲルの最新動向- 機能材料 (2012)
  • Author(s): 荏原充宏
  • Publisher: シーエムシー出版
• [Remarks]
  • URL: http://www.nims.go.jp/bmc/group/smartbiomaterials/
• [Patent(Industrial Property Rights)] 架橋ポリマーゲル-処理体の製造方法, 架橋性ポリマー内包-配位結合性ポリマーゲル, 架橋性ポリマー内包-配位結合性ポリマーゲル-処理体, 架橋ポリマー内包-配位結合性ポリマーゲル-処理体及び架橋ポリマーゲル-特別構造処理体 (2014)
  • Inventor(s): 青柳隆夫, 荏原充宏, 佐藤健
  • Industrial Property Rights Holder: 物質材料研究機構
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-094421
  • Filing Date: 2014-05-01
• [Patent(Industrial Property Rights)] 細胞間情報伝達分子産生信号誘発機能高分子及びその合成方法 (2013)
  • Inventor(s): 荏原充宏, 青柳隆夫
  • Industrial Property Rights Holder: 物質材料研究機構
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-236845
  • Filing Date: 2013-11-15
• [Patent(Industrial Property Rights)] 癌細胞吸着膜、癌細胞吸着デバイス、癌細胞吸着デバイスの作成方法及び癌細胞除去装置 (2013)
  • Inventor(s): 青柳隆夫、荏原充宏
  • Industrial Property Rights Holder: （独）物質・材料研究機構
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-175387
  • Filing Date: 2013-08-27
• [Patent(Industrial Property Rights)] 自己発熱/薬物放出機能性ナノファイバー、その製造方法及び自己発熱/薬物放出機能性不織布 (2013)
  • Inventor(s): 荏原充宏、青柳隆夫
  • Industrial Property Rights Holder: （独）物質・材料研究機構
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-003341
  • Filing Date: 2013-01-11
• [Patent(Industrial Property Rights)] 分岐型ポリマー、架橋ポリマー、インジェクタブルハイドロゲル、ハイドロゲル形成用キット (2012)
  • Inventor(s): 青柳隆夫、荏原充宏、田中信治、菊池明彦、麻生隆彬
  • Industrial Property Rights Holder: （独）物質・材料研究機構
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-108661
  • Filing Date: 2012-05-10
• [Patent(Industrial Property Rights)] HVJ-E及び被覆HVJ-Eの製造方法 (2011)
  • Inventor(s): 荏原充宏、宇都甲一郎、青柳隆夫、李千萬
  • Industrial Property Rights Holder: 物質・材料研究機構
  • Filing Date: 2011