| Project/Area Number |
23650322
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nagoya University |
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Principal Investigator |
YAMADA Sumio 名古屋大学, 医学系研究科(保健), 教授 (80359752)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAKIBARA Hisataka 名古屋大学, 医学部, 教授 (80153873)
ISODA Haruo 名古屋大学, 医学部, 教授 (40223060)
KONDO Takaaki 名古屋大学, 医学部, 教授 (00195900)
FUKUYAMA Atsushi 名古屋大学, 医学部, 教授 (40452198)
UEYAMA Jun 名古屋大学, 医学部, 教授 (00397465)
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| Research Collaborator |
HASEGAWA Yasuhiro 名古屋第二赤十字病院, 神経内科, 部長
KONO Yuji 名古屋大学, 大学院・医学系研究科リハビリテーション療法学, 専攻
IRITANI Naoki 名古屋大学, 大学院・医学系研究科リハビリテーション療法学, 専攻
ISHIDA Shimpei 名古屋大学, 大学院・医学系研究科リハビリテーション療法学, 専攻
AKAO Keigo 名古屋大学, 大学院・医学系研究科リハビリテーション療法学, 専攻
ASAI Chikako 名古屋大学, 大学院・医学系研究科リハビリテーション療法学, 専攻
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 理学療法学 / 軽症脳梗塞 / 脳血流量 / 血管内皮機能 / ライフスタイル介入 / 脳血流 / ％FMD |
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| Research Abstract |
In this pilot study, we investigated 1) the relationship between cerebral blood flow(CBF) measured by Magnetic Resonance Imaging(ASL method) and peripheral endothelial function measured by flow-mediated total dilation (%FMTD), and 2) the effect of lifestyle intervention on CBF in mild ischemic stroke patients. [Results] CBF in lacunar stroke(LS) showed a tendency toward greater than that of atherosclerotic stroke(AS). We found, however, no relationship between CBF and %FMTD in entire or each group, suggesting statin use in AS may be confounder to this relationship. Cognitive function, high intensity physical activity and serum albumin level in secondary outcomes were significantly correlated with CBF , suggesting a need to clear cause-effect relationship between those correlants and CBF. In non randomized intervention study, after 6-months lifestyle intervention, %FMTD increased but not significant only in the intervention group. We found no change of CBF in intervention, while a tendency to decrease in control,suggesting a possibility that the lifestyle intervention in terms of CBF in mild stroke may be a countermeasure to "decrease" in CBF .
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