Analysis of the innate immune response to nucleic acids in tumor cells.
| Project/Area Number |
23650586
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Carcinogenesis
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| Research Institution | Hokkaido University |
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Principal Investigator |
HAYAKAWA Sumio 北海道大学, 遺伝子病制御研究所, 助教 (00368292)
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| Co-Investigator(Kenkyū-buntansha) |
KAMEYAMA Takeshi 北海道大学, 遺伝子病制御研究所, 研究員 (40569505)
ADACHI Yoshihiro Christopher 北海道大学, 遺伝子病制御研究所, 研究員 (10616204)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 自然免疫 / 腫瘍 / 抗腫瘍 / インターフェロン |
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| Research Abstract |
Pattern recognition receptors (PRRs)-mediated activation of the innate immune response is triggered by recognition of pathogen-associated molecular patterns (PAMPs), such as a various bacterial cell wall components, peptidoglycan and lipoprotein, as well as bacterial and viral nucleic acids. In this study, we demonstrate that nucleic acids are recognized by PRRs in some tumor types, and promoted the activation of IRF and NF-kB pathway. However, some types of tumor cells are not activated. Furthermore, we are able to find the relationship between the tissue specificity of innate immune response and apoptosis induction. In in vivo experiment, nucleic acids inhibit growth of transplantation tumor in nude mice. Thus, these finding indicate that nucleic acids may contribute to the progress of material for therapeutic cancer. We consider clarifying the detail mechanism of nucleic acids recognition on innate immune response from the molecular, biochemical and cell biology viewpoints.
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Report
(4 results)
Research Products
(1 results)
