Development of novel therapy targeting the Warburg effect of cancer
| Project/Area Number |
23650629
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Clinical oncology
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| Research Institution | Miyagi Cancer Center Research Institute |
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Principal Investigator |
SATO Ikuro 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), ティッシュバンクセンター, センター長 (50225918)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Shigemi 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (80600006)
TANUMA Nobuhiro 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 主任研究員 (40333645)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 代謝 / 解糖系 / ワールブルグ効果 / PKM / スプライシング / 分子標的治療 / 代謝異常 |
|---|
| Research Abstract |
A glycolytic enzyme, pyruvate kinase M (PKM), has been suggested to play important roles in altered metabolism in cancer cells. In this study, we analyzed splicing regulation of the PKM gene in tumor. Analysis using clinical specimens revealed that pre-mRNA splicing of PKM gene switches from M1- to M2-type in most case of various human cancers. In addition, we developed a reporter gene enabling us to detect PKM conversion in living cells.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] H:Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas2012
Author(s)
Nomura M, Shiiba K, Katagiri C, Kasugai I, Masuda K, Sato I, Sato M, Kakugawa Y, Nomura E, Hayashi K, Nakamura Y, Nagata T, Otsuka T, Katakura R, Yamashita Y, Sato M, Tanuma N, Shima H
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Journal Title
Oncol Rep.
Volume: 28(3)
Pages: 931-6
Related Report
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[Journal Article] Plasma membrane-associated sialidase (NEU3) regulates progression of prostate cancer to androgen-independent growth through modulation of androgen receptor signaling2012
Author(s)
Kawamura S, Sato I, Wada T, Yamaguchi K, Li Y, Li D, Zhao X, Ueno S, Aoki H, Tochigi T, Kuwahara M, Kitamura T, Takahashi K, Moriya S, Miyagi T
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Journal Title
Cell Death Differ.
Volume: 19(1)
Pages: 170-9
Related Report
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[Journal Article] Reduced susceptibility to colitis-associated colon carcinogenesis in mice lacking plasma membrane-associated sialidase2012
Author(s)
Yamaguchi, K., Shiozaki, K., Moriya, S., Koseki, K., Wada, T., Tateno, H., Sato, I., Asano, M., Iwakura, Y., and Miyagi, T.
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Journal Title
PLoS ONE
Volume: 7
Issue: 7
Pages: e41132-e41132
DOI
Related Report
Peer Reviewed
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[Journal Article] DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression2011
Author(s)
Katagiri C, Masuda K, Nomura M, Tanoue K, Fujita S, Yamashita Y, Katakura R, Shiiba K, Nomura E, Sato M, Tanuma N, Shima H
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Journal Title
Mol Cell Biochem
Volume: 352(1-2)
Issue: 1-2
Pages: 155-62
DOI
Related Report
Peer Reviewed
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