S100A8/A9 as a new mediator of arsenic toxicity

• Project/Area Number: 23651056
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Tokushima Bunri University
• Principal Investigator: HIMENO Seiichiro 徳島文理大学, 薬学部, 教授 (20181117)
• Research Collaborator: SUMI Daigo 徳島文理大学, 薬学部, 准教授 ; SHIMIZU Yuri 徳島文理大学, 薬学部, 大学院生 ; KHALED Hossain バングラデシュ国立ラッシャイ大学, 生化学分子生物学科, 教授
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ヒ素 / 毒性 / 免疫 / S100A8 / S100A9 / 免疫機能 / 炎症

Research Abstract

S100A8/A9 proteins are known to be involved in inflammation and cancer immunity. We showed that exposure to arsenic induces expression of S100A9 in various types of cells and that transcription factor Nrf2 is involved in enhanced transcription of S100A9 gene. We also detected high concentrations of S100A8/A9 among the residents living in arsenic-endemic areas in Bangladesh, suggesting an important role of S100A8/A9 in arsenic intoxication.

Research Products

• [Journal Article] Increases in oxidized low density lipoprotein and other inflammatory and adhesion molecules with a concomitant decrease in high density lipoprotein in the individuals exposed to arsenic in Bangladesh. (2013)
  • Author(s): Karim, M. R., Rahman, M., Islam, K., Mamun, A. A., Hossain, H., Hossain, E., Aziz, A., Yeasmin, F., Agarwal, S., Saud, Z. A., Nikkon, F., Hossain, M., Mandal, A.,Jenkins, R. O., Haris, P. I., Miyataka, H., Himeno, S., and Hossain, K.
  • Journal Title: Toxicol. Sci Volume: (in press)
  • Peer Reviewed
• [Journal Article] Involvement of Nrf2 activation in the upregulation of S100A9 by exposure to inorganic arsenite. (2013)
  • Author(s): Sumi, D., Shimizu Y., Himeno S.
  • Journal Title: Int. J. Mol. Med. Volume: 31(1) Issue: 1 Pages: 259-264
  • DOI: 10.3892/ijmm.2012.1185
  • Peer Reviewed
• [Journal Article] Increases in oxidized low density lipoprotein and other inflammatory and adhesion molecules with a concomitant decrease in high density lipoprotein in the individuals exposed to arsenic in Bangladesh. (2013)
  • Author(s): Karim MR et al.
  • Journal Title: Toxicol. Sci. Volume: in revision
  • Peer Reviewed
• [Journal Article] Elevated levels of plasma Big endothelin-1 and its relation to hypertension and skin lesions in individuals exposed to arsenic (2012)
  • Author(s): Hossain, E., et al
  • Journal Title: Toxicol.Appl.Pharmacol. Volume: 259(2) Issue: 2 Pages: 187-194
  • DOI: 10.1016/j.taap.2011.12.023
  • Peer Reviewed
• [Journal Article] (2011)Dose-response relationship between arsenic exposure and the serum enzymes for liver function tests in the individuals exposed to arsenic: a cross sectional study in Bangladesh. (2011)
  • Author(s): Islam, K., Haque, A., Karim, M. R., Fajol, A., Hossain, E., Salam, K. A., Ali, N., Saud, Z. A., Rahman, M., Rahman,M., Sultana, P., Hossain, M., Akhand, A.A., Mandal, A., Miyataka, H., Himeno, S., Hossain, K.
  • Journal Title: Environ. Health Volume: 10(1), 64 Issue: 1 Pages: 1-11
  • DOI: 10.1186/1476-069x-10-64
  • Peer Reviewed
• [Journal Article] Chronic exposure to arsenite induces S100A8 and S100A9 expression in rat RBL-2H3 mast cells (2011)
  • Author(s): Shimizu, Y., Fujishiro, H., Matsumoto, K., Sumi, D., Satoh, M., Himeno, S.
  • Journal Title: The Journal of Toxicological Sciences Volume: 36 Issue: 1 Pages: 135-139
  • DOI: 10.2131/jts.36.135
  • NAID: 10027420605
  • ISSN: 0388-1350, 1880-3989
  • Peer Reviewed
• [Presentation] 亜ヒ酸がマスト細胞の応答性と遺伝子発現に及ぼす影響 (2012)
  • Author(s): 姫野誠一郎、清水由里、角大悟.
  • Organizer: 第18回ヒ素シンポジウム.
  • Place of Presentation: 宮崎
• [Presentation] 亜ヒ酸がマスト細胞の応答性と遺伝子発現に及ぼす影響 (2012)
  • Author(s): ○姫野誠一郎、清水由里、角 大悟
  • Organizer: 第18回ヒ素シンポジウム
  • Place of Presentation: 宮崎
• [Presentation] バングラデシュヒ素汚染地域住民の毛髪、爪、尿、および飲用水のヒ素濃度の分析 (2011)
  • Author(s): 池村憲明,井上潔,宮高透喜,姫野誠一郎.
  • Organizer: 第22回日本微量元素学会.
  • Place of Presentation: 京都
• [Presentation] バングラデシュ ヒ素汚染地域住民の毛髪、爪、尿、および飲用水のヒ素濃度の分析 (2011)
  • Author(s): 池村憲明, 井上 潔, 宮高透喜, 姫野誠一郎
  • Organizer: 第22回日本微量元素学会
  • Place of Presentation: 京都テルサ（京都）
• [Remarks] 徳島文理大学薬学部・衛生化学講座
  • URL: http://p.bunri-u.ac.jp/lab10/index.html