Development of micro blood-brain barrier
Project/Area Number |
23651134
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Microdevices/Nanodevices
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Research Institution | Gunma University |
Principal Investigator |
SATO Kiichi 群馬大学, 大学院・工学研究科, 准教授 (50321906)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | マイクロチップ / 血液脳関門 / 動物実験代替法 / マイクロ流体デバイス / バイオアッセイ |
Research Abstract |
PDMS microchip with a porous membrane for cell culture support was developed as a micro model of the blood-brain barrier. Vascular endothelial cell line from monkey and human fibroblast-like cell line were co-cultured on both sides of the membrane. Permeability tests of fluorescent molecules were conducted with the microfluidic device. I confirmed the cell sheet in the device acted as a permeability barrier.
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Report
(3 results)
Research Products
(10 results)