Development ofa newdiagnostic methodby using"diagnosis molecule" for adisease with carbohydrataebnormality
| Project/Area Number |
23651232
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 診断薬探索 / 糖鎖診断 / 糖鎖 / 生体分子 / 細胞・組織 / 酵素 / 糖 / アルキルラクトシド / 糖脂質 / 細胞 / 診断分子 / 糖鎖生合成 / シアリル化 / GM３ / 診断 |
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| Research Abstract |
It was shown that saccharide synthesis in the cell can be observed in several hours by adding dodecyl lactoside as " The molecules which diagnose a cell" to the culture medium. When a molecule which affects on saccharide synthesis was added with dodecyl lactoside, change of saccharide synthesis was easily observed. The conjugate of oligosaccharide of glycoprotein and dodecyl chain could be used for the analysis of chain elongation of oligosaccharide. Moreover, it could be done with fluorous glycoside.
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Report
(3 results)
Research Products
(18 results)
