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Protein delivery and targeting to neuronal cells and its fluorescence imaging

Research Project

Project/Area Number 23651237
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Chemical biology
Research InstitutionOsaka University

Principal Investigator

HORI Yuichiro  大阪大学, 大学院・工学研究科, 助教 (00444563)

Project Period (FY) 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywords神経細胞 / デリバリー / ペプチド / アセチルコリン受容体 / Rabies virus糖蛋白質 / RVG29
Research Abstract

he molecular delivery to the central nervous system is required for the diagnosis and treatment of neurodegenerative diseases require. In this research, we developed a technique for protein delivery to neuronal cells using RVG peptide derived from rabies virus glycoprotein. We also discovered novel peptides as carriers to neuronal cells by synthesizing nAChR-binding peptides. These peptides allow the selective internalization of a protein and a small molecule probe into neuronal cells.

Report

(2 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (8 results)

All 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Development of Protein-Labeling Probes with Redesigned Fluorogenic Switch Based on Intramolecular Association for No-wash Live-cell Imaging2012

    • Author(s)
      Hori, Y., Nakaki, K., Sato, M., Mizukami, S., Kikuchi, K.
    • Journal Title

      Angew. Chem. Int. Ed

      Volume: (In press) Issue: 23 Pages: 5611-5614

    • DOI

      10.1002/anie.201200867

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] ジメチルアミノクマリン誘導体をリガンドとした新規発蛍光型PYPタグプローブの開発と無洗浄生細胞イメージング2012

    • Author(s)
      堀雄一郎、則信智哉、菊地和也
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] PYPタグと新規桂皮酸型プローブを利用した蛋白質ラベル化法の開発と無洗浄生細胞イメージング2012

    • Author(s)
      堀雄一郎、中木恭兵、佐藤基、菊地和也
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2012-03-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Photoactive Yellow Protein(PYP)タグと蛍光強度増大型プローブを利用した蛋白質標識法の開発と生細胞イメージング2011

    • Author(s)
      堀雄一郎、中木恭兵、則信智也、菊地和也
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      筑波
    • Year and Date
      2011-09-12
    • Related Report
      2011 Final Research Report
  • [Presentation] アセチルコリン受容体結合ペプチドによる蛋白質の神経細胞導入に関する研究2011

    • Author(s)
      堀雄一郎、江頭有佳、村松慎一、菊地和也
    • Organizer
      第6回ケミカルバイオロジー学会
    • Year and Date
      2011-09-12
    • Related Report
      2011 Final Research Report
  • [Presentation] アセチルコリン受容体結合ペプチドによる蛋白質の神経細胞導入に関する研究2011

    • Author(s)
      堀雄一郎
    • Organizer
      第6回日本ケミカルバイオロジー学会年会
    • Place of Presentation
      東京工業大学(東京都)
    • Year and Date
      2011-05-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Design of Fluorogenic Probes for Protein Labeling Method Based on Photoactive Yellow Protein(PYP) Tag and Live Cell Imaging2011

    • Author(s)
      Hori, Y., Nakaki, K., Norinobu, T., Kikuchi, K.
    • Organizer
      Nature Chemical Biology Symposium 2011
    • Place of Presentation
      USA
    • Related Report
      2011 Final Research Report
  • [Remarks] ホームページ

    • URL

      http://www-molpro.mls.eng.osaka-u.ac.jp

    • Related Report
      2011 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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