| Project/Area Number |
23651237
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical biology
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| Research Institution | Osaka University |
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Principal Investigator |
HORI Yuichiro 大阪大学, 大学院・工学研究科, 助教 (00444563)
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|---|
| Project Period (FY) |
2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | 神経細胞 / デリバリー / ペプチド / アセチルコリン受容体 / Rabies virus糖蛋白質 / RVG29 |
|---|
| Research Abstract |
he molecular delivery to the central nervous system is required for the diagnosis and treatment of neurodegenerative diseases require. In this research, we developed a technique for protein delivery to neuronal cells using RVG peptide derived from rabies virus glycoprotein. We also discovered novel peptides as carriers to neuronal cells by synthesizing nAChR-binding peptides. These peptides allow the selective internalization of a protein and a small molecule probe into neuronal cells.
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