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Regulation mechanism by hydrogen sulfide anion of electrophilesignaling

Research Project

Project/Area Number 23651239
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Chemical biology
Research InstitutionKumamoto University

Principal Investigator

AKAIKE Takaaki  熊本大学, 大学院・生命科学研究部, 教授 (20231798)

Co-Investigator(Kenkyū-buntansha) FUJII Shigemoto  熊本大学, 大学院・生命科学研究部, 助教 (00325333)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords硫化水素 / 親電子物質 / シグナル伝達 / 8-nitro-cGMP / S-グアニル化
Research Abstract

In the cellular response to oxidative stress, electrophiles suchas 8-nitro-cGMP function as important signal mediators. In this study, we examined thereaction mechanism of hydrogen sulfide-related compounds with electrophiles to revealits role in the signal regulation. As a result, we found that hydrogen sulfide-relatedcompounds react with 8-nitro-cGMP to produce 8-SH-cGMP, and are involved in the regulationof electrophile signaling.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (109 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (56 results) (of which Peer Reviewed: 44 results,  Open Access: 1 results) Presentation (43 results) (of which Invited: 7 results) Book (6 results) Remarks (4 results)

  • [Journal Article] S-Guanylation proteomics for redox-based mitochondrial signaling.2014

    • Author(s)
      Rahaman MM, Sawa T, Ahtesh am AK, Khan S, Inoue H, Irie A. Fujii S, and Akaike T.
    • Journal Title

      Antioxid. Redox Signal.

      Volume: 20 Issue: 2 Pages: 295-307

    • DOI

      10.1089/ars.2012.4606

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Redox signalingby 8-nitro-cyclic guanosinemonophosphate: nitric oxide- andreactive oxygen species-derivedelectrophilic messenger.2013

    • Author(s)
      Fujii S and Akaike T
    • Journal Title

      AntioxidRedox Signal.

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] S-Guanylation proteomics forredox-based mitochondrial signaling2013

    • Author(s)
      Rahaman MM, Sawa T, Ahmed KA, Khan S,Inoue H, Irie A, Fujii S, and Akaike T.
    • Journal Title

      Antioxid Redox Signal

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nitrated cyclic GMPmodulate guard cell signaling inArabidopsis2013

    • Author(s)
      Joudoi T, Shichiri Y, Kamizono N,Akaike T, Sawa T, Yoshitake J, YamadaN, and Iwai S.
    • Journal Title

      Plant Cell

      Volume: 25 Pages: 558-571

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of redox signalling by anelectrophilic cyclic nucleotide.2013

    • Author(s)
      Akaike T, Nishida M, and Fujii S
    • Journal Title

      JBiochem.

      Volume: 153 Pages: 131-138

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nitricoxide/soluble guanylyl cyclasesignaling mediatesdepolarization-induced protection ofrat mesencephalic dopaminergicneurons from MPP(+) cytotoxicity2013

    • Author(s)
      Kurauchi Y, Hisatsune A, Isohama Y,Sawa T, Akaike T, and Katsuki H.
    • Journal Title

      Neuroscience.

      Volume: 231 Pages: 206-215

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] S-nitrosated α-1-acid glycoproteinkills drug-resistant bacteria and aidssurvival in sepsis2013

    • Author(s)
      Watanabe K, Ishima Y, Akaike T, Sawa T,Kuroda T, Ogawa W, Watanabe H, SuenagaA, Kai T, Otagiri M, and Maruyana T
    • Journal Title

      FASEB J.

      Volume: 27 Pages: 391-398

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Redox signaling by 8-nitro-cyclic guanosine monophosphate : nitric oxide- and reactive oxygen species-derived electrophilic messenger2013

    • Author(s)
      Fujii S and Akaike T.
    • Journal Title

      Antioxid. Redox Signal.

      Volume: 19 Issue: 11 Pages: 1236-1246

    • DOI

      10.1089/ars.2012.5067

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitrated cyclic GMP modulates guard cell signaling in Arabidopsis2013

    • Author(s)
      Joudoi T, Hatakeyama T, Maeda T, Akaike T, Sawa T and Iwai S.
    • Journal Title

      Plant Cell

      Volume: 25 Issue: 2 Pages: 558-571

    • DOI

      10.1105/tpc.112.105049

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide/soluble guanylyl cyclase signaling mediates depolarization-induced protection of rat mesencephalic dopaminergic neurons from MPP+ cytotoxicity2013

    • Author(s)
      Kurauchi Y, Hisatsune A, Isohama Y, Sawa T, Akaike T and Katsuki H.
    • Journal Title

      Neurosci.

      Volume: 231 Pages: 206-215

    • DOI

      10.1016/j.neuroscience.2012.11.044

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of redox signaling by an electrophilic cyclic nucleotide.2013

    • Author(s)
      Akaike T, Nishida M and Fujii S.
    • Journal Title

      J. Biochem.

      Volume: 153 Issue: 2 Pages: 131-138

    • DOI

      10.1093/jb/mvs145

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] S-nitrosylated a-l-acid glycoprotein kills drug-resistant bacteria and aids survival in sepsis2013

    • Author(s)
      Watanabe K, Ishima Y, Akaike T, Sawa T, Kuroda T, Ogawa W, Watanabe H, Suenaga A, Kai T, Otagiri M, and Maruyama T.
    • Journal Title

      FASEB J

      Volume: 27 Issue: 1 Pages: 391-398

    • DOI

      10.1096/fj.12-217794

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of and screening forhuman Helicobacter cinaedi infectionsand carriers via nested PCR2012

    • Author(s)
      Oyama K, Khan S, Okamoto T, Fujii S, OnoK, Matsunaga T, Yoshitake J, Sawa T,Tomida J, Kawamura Y, and Akaike T
    • Journal Title

      J ClinMicrobiol

      Volume: 50 Pages: 3893-3900

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide promotes recycling of8-nitro-cGMP, a cytoprotectivemediator, into intact cGMP in cells2012

    • Author(s)
      Saito Y, Sawa T, Yoshitake J, Ito C,Fujii S, Akaike T, and Arimoto H
    • Journal Title

      Mol Biosyst

      Volume: 8 Pages: 2909-2915

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogensulfide anion regulates redoxsignaling via electrophilesulfhydration.2012

    • Author(s)
      Nishida M, Sawa T, Kitajima N, Ono K,Inoue H, Ihara H, Motohashi H, YamamotoM, Suematsu M, Kurose H, van der VlietA, Freeman BA, Shibata T, Uchida K,Kumagai Y, and Akaike T
    • Journal Title

      Nat Chem Bio

      Volume: 8 Pages: 714-724

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] HGF-mediated inhibitionof oxidative stress by 8-nitro-cGMP inhigh glucose-treated rat mesangialcells.2012

    • Author(s)
      Guoguo S, Akaike T, Tao J, Qi C, NongZ, and Hui L.
    • Journal Title

      Free Radic Res

      Volume: 46 Pages: 1238-1248

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] a novel target ofHNF4α interacts with GRP78 andregulates endoplasmic reticulumstress-induced apoptosis inpancreatic β-cells2012

    • Author(s)
      Sato Y, Hatta M, Karim MF, Sawa T, WeiF-Y, Sato S, Magnuson MA, Gonzalez FJ,Tomizawa K, Akaike T, Yoshizawa T, andYamagata K. Anks4b
    • Journal Title

      J Biol Chem.

      Volume: 287 Pages: 23236-23245

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complete genome sequenceof Helicobacter cinaedi strain PAGU611,isolated in a case of human bacteremia2012

    • Author(s)
      Goto T, Ogura Y, Hirakawa H, Tomida J,Morita Y, Akaike T, Hayashi T, andKawamura Y.
    • Journal Title

      J Bacteriol.

      Volume: 194 Pages: 3744-3745

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] S-Guanylation of human serum albuminis a unique posttranslationalmodification and results in a novelclass of antibacterial agents2012

    • Author(s)
      Ishima Y, Hoshino H, Shinagawa T,Watanabe K, Akaike T, Sawa T,Kragh-hansen U, Kai T, Watanabe H,Maruyama T, and Otagiri M.
    • Journal Title

      J PharmSci.

      Volume: 101 Pages: 3222-3229

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 藤井重元、赤池孝章2012

    • Author(s)
      藤井重元、赤池孝章
    • Journal Title

      感染・炎症・免疫

      Volume: 42 Pages: 235-237

    • Related Report
      2012 Final Research Report
  • [Journal Article] 概論 : 活性酸素によるレドックス制御の新たなパラダイム転換に迫る2012

    • Author(s)
      赤池孝章.
    • Journal Title

      実験医学増刊:活性酸素・ガス状分子による恒常性制御と疾患

      Volume: 30 Pages: 2690-2696

    • Related Report
      2012 Final Research Report
  • [Journal Article] ROS・親電子リガンドとガス状分子のシグナルネットワーク2012

    • Author(s)
      澤 智裕、赤池孝章
    • Journal Title

      実験医学増刊:活性酸素・ガス状分子による恒常性制御と疾患

      Volume: 30 Pages: 2740-2745

    • Related Report
      2012 Final Research Report
  • [Journal Article] Potential association of Helicobactercinaedi with atrial arrhythmia andatherosclerosis2012

    • Author(s)
      Khan S, Okamoto T, Enomoto K, SakashitaN, Oyama K, Fujii S, Sawa T, Takeya M,Ogawa H, Yamabe H, and Akaike T
    • Journal Title

      Microbiol Immunol

      Volume: 56 Pages: 145-154

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] egulation bymitochondrial superoxide and NADPHoxidase of cellular formation ofnitrated cyclic GMP: potentialimplications for ROS signalling2012

    • Author(s)
      Ahmed KA, Sawa T, Ihara H, Kasamatsu S,Yoshitake J, Rahaman MM, Okamoto T,Fujii S, and Akaike T
    • Journal Title

      Biochem J.

      Volume: 441 Pages: 719-730

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration.2012

    • Author(s)
      Nishida M., et al
    • Journal Title

      Nature Chen. Biol.

      Volume: 8 Issue: 8 Pages: 714-724

    • DOI

      10.1038/nchembio.1018

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of and screening for human Helicobacter cinaedi infections and carriers via nested PCR2012

    • Author(s)
      Oyama K, et al
    • Journal Title

      J Clin Microbiol

      Volume: 50 Issue: 12 Pages: 3893-3900

    • DOI

      10.1128/jcm.01622-12

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide promotes recycling of 8-nitro-cGMP, a cytoprotectivemediator, into intact cGMP in cells2012

    • Author(s)
      Yohei Saito, Tomohiro Sawa, Jun Yoshitake, Chiaki Ito, Shigemoto Fujii, Takaaki Akaike and Hirokazu Arimoto
    • Journal Title

      Moi BioSyst

      Volume: 8 Issue: 11 Pages: 2909-2915

    • DOI

      10.1039/c2mb25189b

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complete genome sequence of Helicobacter cinaedi strain PAGU611, isolated in a case of human bacteremia2012

    • Author(s)
      Goto T, et al
    • Journal Title

      J Bacteriol

      Volume: 194 Issue: 14 Pages: 3744-3745

    • DOI

      10.1128/jb.00645-12

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] S-Guanylation of human serum albumin is a unique posttranslational modification and results in a novel class of antibacterial agents2012

    • Author(s)
      Ishima Y, Hoshino H, Shinagawa T, Watanabe K, Akaike T, Sawa T, Kragh-Hansen U, Kai T, Watanabe H, Maruyama T, and Otagiri M
    • Journal Title

      J. Pharm. Sci

      Volume: 101 Issue: 9 Pages: 3222-3229

    • DOI

      10.1002/jps.23143

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 概論:活性酸素によるレドックス恒常性制御の新たなパラダイム転換に迫る2012

    • Author(s)
      赤池孝章
    • Journal Title

      実験医学

      Volume: 30 Pages: 2690-2696

    • Related Report
      2012 Annual Research Report
  • [Journal Article] ROS・親電子リガンドとガス状分子のシグナルネットワーク2012

    • Author(s)
      澤 智裕 他
    • Journal Title

      実験医学

      Volume: 30 Pages: 2740-2745

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 硫化水素と炎症2012

    • Author(s)
      藤井重元 他
    • Journal Title

      感染・炎症・免疫

      Volume: 42 Pages: 235-237

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Regulation by mitochondrial superoxide and NADPH oxidase of cellular formation of nitrated cyclic GMP : potential implications for ROS signalling2012

    • Author(s)
      Ahmed KA., et al
    • Journal Title

      Biochem J

      Volume: 441 Issue: 2 Pages: 719-730

    • DOI

      10.1042/bj20111130

    • NAID

      120004875062

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 新・活性酸素中毒2012

    • Author(s)
      赤池孝章
    • Journal Title

      ファルマシア

      Volume: 48 Pages: 1-1

    • Related Report
      2011 Research-status Report
  • [Journal Article] 基礎の基礎2012

    • Author(s)
      赤池孝章
    • Journal Title

      細胞工学

      Volume: 31 Pages: 134-137

    • Related Report
      2011 Research-status Report
  • [Journal Article] ニトロ化環状ヌクレオチドによるタンパク質S-グアニル化を介する酸化ストレス適応応答の分子機序2012

    • Author(s)
      藤井重元、赤池孝章
    • Journal Title

      生化学

      Volume: 84 Pages: 124-128

    • NAID

      10030346449

    • Related Report
      2011 Research-status Report
  • [Journal Article] Cellular uptake mechanismsand responses to NO transferred frommono- and poly-S-nitrosated humanserum albumin.2011

    • Author(s)
      Ishima Y, Yoshida F, Kragh-Hansen U,Watanabe K, Katayama N, Nakajou K,Akaike T, Kai T, Maruyama T, andOtagiri M.
    • Journal Title

      Free Radic Res.

      Volume: 45 Pages: 1196-1206

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detoxification of methylmercury byhydrogen sulfide-producing enzyme inmammalian cells2011

    • Author(s)
      Yoshida E, Toyama T, Shinkai Y, Sawa T,Akaike T, and Kumagai Y
    • Journal Title

      Chem Res Toxicol

      Volume: 24 Pages: 1633-1635

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vascular responses to 8-nitro-cyclicGMP in non-diabetic and diabetic mice2011

    • Author(s)
      Tokutomi Y, Kataoka K, Yamamoto E, Nakamura T, Fukuda M, Nako H, Toyama K,Yi-Fei Dong Y-F, Ahmed KA, Sawa T,Akaike T, and Kim-Mitsuyama S
    • Journal Title

      Br J Pharmacol.

      Volume: 162 Pages: 1884-1893

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidant effect of a nitratedcyclic nucleotide functioning as anendogenous electrophile.2011

    • Author(s)
      Sawa T, Ihara H, and Akaike T
    • Journal Title

      Curr Top MedChem.

      Volume: 11 Pages: 1854-1860

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Methodological proof ofimmunochemistry for specificidentification of 8-nitroguanosine3',5'-cyclic monophosphate formed inglia cells.2011

    • Author(s)
      Ihara H, Ahmed KA, Ida T, Kasamatsu S,Kunieda K, Okamoto T, Sawa T, andAkaike T.
    • Journal Title

      Nitric Oxide.

      Volume: 25 Pages: 169-175

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frontiers in nitric oxide and redoxsignaling.2011

    • Author(s)
      Akaike T, van der Vliet A, and Eaton P.
    • Journal Title

      Nitric Oxide.

      Volume: 25 Pages: 57-58

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteincysteine S-guanylation andelectrophilic signal transduction byendogenous nitro-nucleotides.2011

    • Author(s)
      Ahmed KA, Sawa T, and Akaike T
    • Journal Title

      AminoAcids

      Volume: 41 Pages: 123-130

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 活性酸素・一酸化窒素によるニトロ化シグナルと抗炎症作用.2011

    • Author(s)
      澤 智裕、小野勝彦、赤池孝章.
    • Journal Title

      感染・炎症・免疫.

      Volume: 41 Pages: 12-19

    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Journal Article] 喫煙と酸化ストレス : Oxidative stress inducedby cigarette smoking.2011

    • Author(s)
      岡本竜哉、居原 秀、赤池孝章.
    • Journal Title

      最新精神医学

      Volume: 16 Pages: 431-439

    • Related Report
      2012 Final Research Report
  • [Journal Article] 植物精油 citral のインフルエンザウイルス感染 能抑 制効 果に つい て:Experimentalstudy of a citral on the preventiveeffect ofinfluenza virus infection.2011

    • Author(s)
      今吉理恵子、岡本竜哉、永尾潤一、長環、松永勝政、赤池孝章、上西秀則
    • Journal Title

      医学と生物学

      Volume: 155 Pages: 489-494

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frontiers in nitric oxide and redox signaling2011

    • Author(s)
      Akaike T., et al
    • Journal Title

      Nitric Oxide

      Volume: 25 Issue: 2 Pages: 57-58

    • DOI

      10.1016/j.niox.2011.04.015

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Midbrain dopaminergic neurons utilize nitric oxide/cyclic GMP signaling to recruit ERK that links retinoic acid receptor stimulation to up-regulation of BDNF2011

    • Author(s)
      Kurauchi Y., et al
    • Journal Title

      J Neurochem

      Volume: 116 Issue: 3 Pages: 323-333

    • DOI

      10.1111/j.1471-4159.2010.06916.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vascular responses to 8-nitro-cyclic GMP in non-diabetic and diabetic mice2011

    • Author(s)
      Tokutomi Y., et al
    • Journal Title

      Br J Pharmabol

      Volume: 162 Issue: 8 Pages: 1884-1893

    • DOI

      10.1111/j.1476-5381.2011.01201.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Protein cysteine S-guanylation and electrophilic signal transduction by endogenous nitro-nucleotides2011

    • Author(s)
      Ahmed KA., et al
    • Journal Title

      Amino Acids

      Volume: 41 Issue: 1 Pages: 123-130

    • DOI

      10.1007/s00726-010-0535-1

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antioxidant Effect of a Nitrated Cyclic Nucleotide Functioning as an Endogenous Electrophile2011

    • Author(s)
      Sawa T., et al
    • Journal Title

      Curr Top Med Chem

      Volume: 11 Pages: 1854-1860

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Detoxification of methylmercury by hydrogen sulfide-producing enzyme in Mammalian cells2011

    • Author(s)
      Yoshida E, Toyama T (equalcontributor), Shinkai Y, Sawa T, Akaike T, Kumagai Y
    • Journal Title

      Chemical Research in Toxicology

      Volume: 24 Issue: 10 Pages: 1633-1635

    • DOI

      10.1021/tx200394g

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cellular uptake mechanisms and responses to NO transferred from mono- and poly-S-nitrosated human serum albumin2011

    • Author(s)
      Yu Ishima., et al
    • Journal Title

      Free Radical Research

      Volume: 45 Issue: 10 Pages: 1196-1206

    • DOI

      10.3109/10715762.2011.606814

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 喫煙と酸化ストレス:Oxidative stress induced by cigarette smoking2011

    • Author(s)
      岡本竜哉、他
    • Journal Title

      最新精神医学

      Volume: 16 Pages: 431-439

    • Related Report
      2011 Research-status Report
  • [Journal Article] 植物精油 citral のインフルエンザウイルス感染能抑制効果について:Experimental study of a citral on the preventive effect ofinfluenza virus infection2011

    • Author(s)
      今吉理恵子、他
    • Journal Title

      医学と生物学

      Volume: 155 Pages: 489-494

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nucleotides function as endogenous chemical sensors for oxidative stress signaling2010

    • Author(s)
      Ihara H., et al
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 48 Issue: 1 Pages: 33-39

    • DOI

      10.3164/jcbn.11-003FR

    • NAID

      130004879228

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] トップジャーナル七転び八起き2012

    • Author(s)
      赤池孝章
    • Organizer
      第85回日本総会
    • Place of Presentation
      長崎ブリックホール、長細菌学会崎
    • Year and Date
      2012-03-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 硫化水素の抗酸化機能と酸化ストレスバイオマーカー.2012

    • Author(s)
      藤井重元、赤池孝章
    • Organizer
      第8回呼吸器バイオマカ研究会
    • Place of Presentation
      都市センターホテル、東京
    • Year and Date
      2012-03-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Persulfideregulation of redox signalinginvolving unique polysulfur biology2012

    • Author(s)
      Takaaki Akaike
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡、福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] The site specific Cys195 S-guanylation in protein kinaseG 1α responsible for persistenthypotension in sepsis.2012

    • Author(s)
      藤井重元、他 .
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡、福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] ドックスシグナル制御と酸化ストレスバイオマーカー2012

    • Author(s)
      赤池孝章
    • Organizer
      第20回日本精神科救急学会学術総会
    • Place of Presentation
      奈良県新公会堂、奈良
    • Related Report
      2012 Final Research Report
  • [Presentation] 感染防御における活性酸素シグナル制御と破綻2012

    • Author(s)
      赤池孝章
    • Organizer
      第65回日本細菌学会中国 ・四国支部総会
    • Place of Presentation
      徳島大学長井記念ホール、徳島
    • Related Report
      2012 Final Research Report
  • [Presentation] Hydrogen sulfideregulation for electrophile-mediatedROS signaling.2012

    • Author(s)
      Takaaki Akaike
    • Organizer
      Second InternationalConference on H2S Biology and Medicine.
    • Place of Presentation
      Sheraton Atlanta Hotel,Atlanta, USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] オートファジーによるサルモネラの細胞内殺菌と硫化水素による制御.2012

    • Author(s)
      藤井重元、他
    • Organizer
      第65回日本細菌学会九州支部総会
    • Place of Presentation
      那覇市ぶんかテンブス館テンブスホール、那覇市
    • Related Report
      2012 Final Research Report
  • [Presentation] 8-SH-cGMPendogenously formed from 8-nitro-cGMPas a second messenger of hydrogensulfide.2012

    • Author(s)
      Takaaki Akaike, Hideshi Ihara, andTomohiro Sawa
    • Organizer
      The 7th InternationalConference on the Biology, Chemistryand Therapeutic Application of NitricOxide.
    • Place of Presentation
      McIntyreConference Center, Edinburgh, UK
    • Related Report
      2012 Final Research Report
  • [Presentation] Regulation bymitochondrial superoxide and NADPHoxidase of cellular formation ofnitrated cyclic GMP: Potentialimplications for NO and ROS signaling.2012

    • Author(s)
      Shigemoto Fujii, et al.
    • Organizer
      The 7th International Conference onthe Biology, Chemistry and TherapeuticApplication of Nitric Oxide
    • Place of Presentation
      McIntyre ConferenceCenter, Edinburgh, UK
    • Related Report
      2012 Final Research Report
  • [Presentation] 硫化水素によるレドックスシグナル制御:新しいセカンドメッセンジャー 8-SH-cGMP の発見.2012

    • Author(s)
      赤池孝章
    • Organizer
      第12回日本NO 学会学術集会
    • Place of Presentation
      神戸国際会議場、神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] Nitrated cyclicnucleotide mediates endogenouselectrophilic signaling forRas-dependent senescence andautophagy.2012

    • Author(s)
      Takaaki Akaike, Motohiro Nishida, andTomohiro Sawa.
    • Organizer
      The 33rd Naito Conferenceon Oxygen Biology: Hypoxia, Oxidative Stress and Diseases.
    • Place of Presentation
      CHATERAISE Gateaux Kingdom SAPPORO、札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] ydrogensulfide regulates H-Ras-inducedautophagy. The 33rd Naito Conferenceon Oxygen Biology: Hypoxia2012

    • Author(s)
      Shigemoto Fujii, et al.
    • Organizer
      OxidativeStress and Diseases.
    • Place of Presentation
      CHATERAISE Gateaux Kingdom SAPPORO、札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] Nitrated cyclic nucleotide mediates endogenous electrophilic signaling for Ras-dependent senescence and autophagy2012

    • Author(s)
      Takaaki Akaike, et al
    • Organizer
      The 33rd Naito Conference on Oxygen Biology: Hypoxia, Oxidative Stress and Diseases
    • Place of Presentation
      CHATERAISE Gateaux Kingdom SAPPORO、札幌市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 硫化水素によるレドックスシグナル制御:新しいセカンドメッセンジャー 8-SH-cGMP の発見2012

    • Author(s)
      赤池孝章
    • Organizer
      第12回日本NO学会学術集会
    • Place of Presentation
      神戸国際会議場、神戸市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 8-SH-cGMP endogenously formed from 8-nitro-cGMP as a second messenger of hydrogen sulfide2012

    • Author(s)
      Takaaki Akaike, et al
    • Organizer
      The 7th International Conference on the Biology, Chemistry and Therapeutic Application of Nitric Oxide
    • Place of Presentation
      McIntyre Conference Center, Edinburgh, UK
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Hydrogen sulfide regulation for electrophile-mediated ROS signaling2012

    • Author(s)
      Takaaki Akaike
    • Organizer
      Second International Conference on H2S Biology and Medicine
    • Place of Presentation
      Sheraton Atlanta Hotel, Atlanta, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 感染防御における活性酸素シグナル制御と破綻2012

    • Author(s)
      赤池孝章
    • Organizer
      第65回日本細菌学会中国・四国支部総会
    • Place of Presentation
      徳島大学長井記念ホール、徳島市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] レドックスシグナル制御と酸化ストレスバイオマーカー2012

    • Author(s)
      赤池孝章
    • Organizer
      第20回日本精神科救急学会学術総会
    • Place of Presentation
      奈良県新公会堂、奈良市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Persulfide regulation of redox signaling involving unique polysulfur biology2012

    • Author(s)
      Takaaki Akaike
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡、福岡市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] トップジャーナル七転び八起き2012

    • Author(s)
      赤池孝章
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎ブリックホール(長崎)
    • Related Report
      2011 Research-status Report
  • [Presentation] Cellular signalingmediated by nitrated cyclicnucleotides and its regulation byhydrogen sulfide.2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      The 23rd AnnualMeeting of the Korean Society forMolecular and Cellular Biology.
    • Place of Presentation
      COEX, ソウル、韓国
    • Year and Date
      2011-10-06
    • Related Report
      2012 Final Research Report
  • [Presentation] ROS and electrophiliccellular signaling regulated byhydrogen sulfide.2011

    • Author(s)
      赤池孝章、他.
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館、京都
    • Year and Date
      2011-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Antimicrobial cellsignaling mediated by nitrated cyclicnucleotide.2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      第84回日本細菌学会総会
    • Place of Presentation
      札幌コンベンションセンター、札幌
    • Year and Date
      2011-09-06
    • Related Report
      2012 Final Research Report
  • [Presentation] 内因性硫化水素イオンによる ROS・親電子シグナル制 御2011

    • Author(s)
      札幌コンベンションセンター、札幌
    • Organizer
      第2回Molecular Cardiovascular ConferenceII
    • Place of Presentation
      ホテルピアノ、キロロ 北海道
    • Year and Date
      2011-09-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 生体内ガス分子と活性酸素による多次元シグナルネットワーク2011

    • Author(s)
      赤池孝章
    • Organizer
      第8回 Heme Oxygenase 研究フォーラム
    • Place of Presentation
      京都府立医科大学 青蓮会館、京都
    • Year and Date
      2011-08-26
    • Related Report
      2012 Final Research Report
  • [Presentation] ProteinS-guanylation and its uniqueregulation mechanisms involvingcysteine metabolism.2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      12thInternational congress on amino acids,peptides and proteins.
    • Place of Presentation
      Beijing International ConventionCenter, 北京、中国
    • Year and Date
      2011-08-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 親電子シグナルと硫化水素2011

    • Author(s)
      赤池孝章
    • Organizer
      九州大学生体防御医学研究所共同利用研究集会
    • Place of Presentation
      九州大学 生体防御医学研究所会議室、福岡
    • Year and Date
      2011-07-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 内因性硫化水素イオンによる親電子シグナル制御.2011

    • Author(s)
      赤 池 孝 章
    • Organizer
      第64回日本酸化ストレス学会学術集会
    • Place of Presentation
      ルスツリゾートホテル&コンベンション、留寿都 北海道
    • Year and Date
      2011-07-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Cellular signalingmediated by nitrated cyclic nucleotideand regulated by hydrogen sulfide.2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      第5回 cGMP 国 際 会 議
    • Place of Presentation
      Lowengebaude, Halle, Germany
    • Year and Date
      2011-06-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 活性酸素シグナルと加齢2011

    • Author(s)
      Lowengebaude, Halle, Germany
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      国立京都国際会館、京都
    • Year and Date
      2011-05-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Electrophiliccellular signaling regulated byH_2S-medaited sulfhydration.2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      第11回日本 NO 学会学術集会
    • Place of Presentation
      昭和薬科大学、町田市 東京都
    • Year and Date
      2011-05-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Electrophilic cellular signaling regulated by H2S-medaited sulfhydration.2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      第11回日本NO学会総会(招待講演)
    • Place of Presentation
      昭和薬科大学(東京都 町田)
    • Related Report
      2011 Research-status Report
  • [Presentation] 活性酸素シグナル伝達と加齢2011

    • Author(s)
      赤池孝章
    • Organizer
      第11回日本抗加齢医学会総会(招待講演)
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] Cellular signaling mediated by nitrated cyclic nucleotide and regulated by hydrogen sulfide.2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      第5回cGMP国際会議(招待講演)
    • Place of Presentation
      Lowengebaude (Halle, Germany)
    • Related Report
      2011 Research-status Report
  • [Presentation] 内因性硫化水素イオンによる親電子シグナル制御2011

    • Author(s)
      赤池孝章
    • Organizer
      第64回日本酸化ストレス学会学術集会(招待講演)
    • Place of Presentation
      ルスツリゾートホテル&コンベンション (北海道 留寿都)
    • Related Report
      2011 Research-status Report
  • [Presentation] 親電子シグナルと硫化水素2011

    • Author(s)
      赤池孝章
    • Organizer
      九州大学生体防御医学研究所共同利用研究集会(招待講演)
    • Place of Presentation
      九州大学 生体防御医学研究所会議室(福岡)
    • Related Report
      2011 Research-status Report
  • [Presentation] Protein S-guanylation and its unique regulation mechanisms involving cysteine metabolism.2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      12th International congress on amino acids, peptides and proteins(招待講演)
    • Place of Presentation
      Beijing International Convention Center (北京)
    • Related Report
      2011 Research-status Report
  • [Presentation] 生体内ガス分子と活性酸素による多次元シグナルネットワーク2011

    • Author(s)
      赤池孝章
    • Organizer
      第8回Heme Oxygenase 研究フォーラム(招待講演)
    • Place of Presentation
      京都府立医科大学 青蓮会館(京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] 内因性硫化水素イオンによるROS・親電子シグナル制御2011

    • Author(s)
      赤池孝章
    • Organizer
      第2回Molecular Cardiovascular Conference II(招待講演)
    • Place of Presentation
      ホテルピアノ(北海道 キロロ)
    • Related Report
      2011 Research-status Report
  • [Presentation] Antimicrobial cell signaling mediated by nitrated cyclic nucleotide.2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      第84回日本細菌学会総会(招待講演)
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Related Report
      2011 Research-status Report
  • [Presentation] ROS and electrophilic cellular signaling regulated by hydrogen sulfide2011

    • Author(s)
      赤池孝章、他
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] Cellular signaling mediated by nitrated cyclic nucleotides and its regulation by hydrogen sulfide2011

    • Author(s)
      Takaaki Akaike
    • Organizer
      The 23rd Annual Meeting of the Korean Society for Molecular and Cellular Biology(招待講演)
    • Place of Presentation
      COEX (ソウル 韓国)
    • Related Report
      2011 Research-status Report
  • [Book] NO シグナリングNO signalingイラストで徹底理解するシグナル伝達キーワード事典(山本雅,仙波憲太郎,山梨裕司 編).2012

    • Author(s)
      藤井重元、赤池孝章
    • Publisher
      羊土社
    • Related Report
      2012 Final Research Report
  • [Book] 一酸化窒素 nitricoxide/NO. 免疫の事典(桂 義元, 河本宏, 小安重夫, 山本一彦 編).2011

    • Author(s)
      澤 智裕、赤池孝章.
    • Total Pages
      39
    • Publisher
      朝倉書店
    • Related Report
      2012 Final Research Report
  • [Book] 活 性 酸 素reactive oxygen species (ROS). 免疫の事典(桂 義元, 河本 宏, 小安重夫,山本一彦 編)2011

    • Author(s)
      澤智裕,赤池孝章
    • Total Pages
      109
    • Publisher
      朝倉書店
    • Related Report
      2012 Final Research Report
  • [Book] Antioxidant adaptive response of malignant glioma related to resistance to antitumor treatment. In Novel Therapeutic Concepts in Targeting Glioma (eds., Faris Farassati), p. 247-2622011

    • Author(s)
      Sawa, T., Akaike T
    • Total Pages
      16
    • Publisher
      InTech (Open Access Company)
    • Related Report
      2011 Research-status Report
  • [Book] 免疫の事典(桂 義元, 河本 宏, 小安重夫, 山本一彦 編) 一酸化窒素 nitric oxide/NO. p. 392011

    • Author(s)
      澤 智裕、赤池孝章
    • Total Pages
      1
    • Publisher
      朝倉書店
    • Related Report
      2011 Research-status Report
  • [Book] 免疫の事典(桂 義元, 河本 宏, 小安重夫, 山本一彦 編) 活性酸素 reactive oxygen species (ROS). p. 1092011

    • Author(s)
      澤 智裕、赤池孝章
    • Total Pages
      1
    • Publisher
      朝倉書店
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://kumadai-bisei.com/

    • Related Report
      2012 Final Research Report
  • [Remarks] 熊本大学大学院生命科学研究部微生物学分野ホームページ

    • URL

      http://kumadai-bisei.com/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://kumadai-bisei.com/

    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.ros-signal.jp/

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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