Regulation mechanism by hydrogen sulfide anion of electrophilesignaling
| Project/Area Number |
23651239
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Chemical biology
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
AKAIKE Takaaki 熊本大学, 大学院・生命科学研究部, 教授 (20231798)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FUJII Shigemoto 熊本大学, 大学院・生命科学研究部, 助教 (00325333)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 硫化水素 / 親電子物質 / シグナル伝達 / 8-nitro-cGMP / S-グアニル化 |
|---|
| Research Abstract |
In the cellular response to oxidative stress, electrophiles suchas 8-nitro-cGMP function as important signal mediators. In this study, we examined thereaction mechanism of hydrogen sulfide-related compounds with electrophiles to revealits role in the signal regulation. As a result, we found that hydrogen sulfide-relatedcompounds react with 8-nitro-cGMP to produce 8-SH-cGMP, and are involved in the regulationof electrophile signaling.
|
Report
(3 results)
Research Products
(109 results)
-
-
-
-
-
-
-
[Journal Article] S-nitrosated α-1-acid glycoproteinkills drug-resistant bacteria and aidssurvival in sepsis2013
Author(s)
Watanabe K, Ishima Y, Akaike T, Sawa T,Kuroda T, Ogawa W, Watanabe H, SuenagaA, Kai T, Otagiri M, and Maruyana T
-
Journal Title
FASEB J.
Volume: 27
Pages: 391-398
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] S-nitrosylated a-l-acid glycoprotein kills drug-resistant bacteria and aids survival in sepsis2013
Author(s)
Watanabe K, Ishima Y, Akaike T, Sawa T, Kuroda T, Ogawa W, Watanabe H, Suenaga A, Kai T, Otagiri M, and Maruyama T.
-
Journal Title
FASEB J
Volume: 27
Issue: 1
Pages: 391-398
DOI
Related Report
Peer Reviewed
-
[Journal Article] Identification of and screening forhuman Helicobacter cinaedi infectionsand carriers via nested PCR2012
Author(s)
Oyama K, Khan S, Okamoto T, Fujii S, OnoK, Matsunaga T, Yoshitake J, Sawa T,Tomida J, Kawamura Y, and Akaike T
-
Journal Title
J ClinMicrobiol
Volume: 50
Pages: 3893-3900
Related Report
Peer Reviewed
-
-
[Journal Article] Hydrogensulfide anion regulates redoxsignaling via electrophilesulfhydration.2012
Author(s)
Nishida M, Sawa T, Kitajima N, Ono K,Inoue H, Ihara H, Motohashi H, YamamotoM, Suematsu M, Kurose H, van der VlietA, Freeman BA, Shibata T, Uchida K,Kumagai Y, and Akaike T
-
Journal Title
Nat Chem Bio
Volume: 8
Pages: 714-724
Related Report
Peer Reviewed
-
-
[Journal Article] a novel target ofHNF4α interacts with GRP78 andregulates endoplasmic reticulumstress-induced apoptosis inpancreatic β-cells2012
Author(s)
Sato Y, Hatta M, Karim MF, Sawa T, WeiF-Y, Sato S, Magnuson MA, Gonzalez FJ,Tomizawa K, Akaike T, Yoshizawa T, andYamagata K. Anks4b
-
Journal Title
J Biol Chem.
Volume: 287
Pages: 23236-23245
Related Report
Peer Reviewed
-
-
[Journal Article] S-Guanylation of human serum albuminis a unique posttranslationalmodification and results in a novelclass of antibacterial agents2012
Author(s)
Ishima Y, Hoshino H, Shinagawa T,Watanabe K, Akaike T, Sawa T,Kragh-hansen U, Kai T, Watanabe H,Maruyama T, and Otagiri M.
-
Journal Title
J PharmSci.
Volume: 101
Pages: 3222-3229
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Potential association of Helicobactercinaedi with atrial arrhythmia andatherosclerosis2012
Author(s)
Khan S, Okamoto T, Enomoto K, SakashitaN, Oyama K, Fujii S, Sawa T, Takeya M,Ogawa H, Yamabe H, and Akaike T
-
Journal Title
Microbiol Immunol
Volume: 56
Pages: 145-154
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] S-Guanylation of human serum albumin is a unique posttranslational modification and results in a novel class of antibacterial agents2012
Author(s)
Ishima Y, Hoshino H, Shinagawa T, Watanabe K, Akaike T, Sawa T, Kragh-Hansen U, Kai T, Watanabe H, Maruyama T, and Otagiri M
-
Journal Title
J. Pharm. Sci
Volume: 101
Issue: 9
Pages: 3222-3229
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
[Journal Article] Vascular responses to 8-nitro-cyclicGMP in non-diabetic and diabetic mice2011
Author(s)
Tokutomi Y, Kataoka K, Yamamoto E, Nakamura T, Fukuda M, Nako H, Toyama K,Yi-Fei Dong Y-F, Ahmed KA, Sawa T,Akaike T, and Kim-Mitsuyama S
-
Journal Title
Br J Pharmacol.
Volume: 162
Pages: 1884-1893
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 親電子シグナルと硫化水素2011
Author(s)
赤池孝章
Organizer
九州大学生体防御医学研究所共同利用研究集会
Place of Presentation
九州大学 生体防御医学研究所会議室、福岡
Year and Date
2011-07-22
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
