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Advanced Molecular Transformation by Concerted Catalysis Based on Organocatalyst/Transition Metal Catalyst Harmonic System

Research Project

Project/Area Number 23655077
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Synthetic chemistry
Research InstitutionTohoku University

Principal Investigator

TERADA Masahiro  東北大学, 大学院・理学研究科, 教授 (50217428)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords不斉合成 / 反応 / 触媒 / 有機分子触媒 / 分子変換 / 環境調和 / 金属錯体 / 酸触媒 / 水素結合 / 分子認識
Research Abstract

The purpose of this research is aimed at establishing the method of supplying the optically active compound in efficient and selective manner. The innovative molecular transformations, which are difficult to realize by the conventional methods, has been achieved by harmonic system composed of the two catalysts, ‘organocatalyst' and ‘transition metal catalyst'. The new catalytic reaction was successfully developed by establishment of the relay catalysis which combined the transition metal catalyst and the organocatalyst.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (25 results)

All 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (13 results) (of which Invited: 2 results) Book (4 results) Remarks (4 results)

  • [Journal Article] Relay Catalysis by a Ruthenium Complex- Chiral Bronsted Acid Binary System for Ternary Reaction Sequence Involving Enantioselective Pictet-Spengler-Type Cyclization as the Key Step2013

    • Author(s)
      Y. Toda, M. Terada
    • Journal Title

      Synlett

      Volume: 24 Issue: 06 Pages: 752-756

    • DOI

      10.1055/s-0032-1318302

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relay Catalysis Using a Rhodium Complex/Chiral Bronsted Acid Binary System : Enantioselective Reduction of a Carbonyl Ylide as the Reactive Intermediate2012

    • Author(s)
      M.Terada, Y.Toda
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 51 Issue: 9 Pages: 2093-2097

    • DOI

      10.1002/anie.201107805

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 最新のトピックス:触媒の”ハイブリッド”―金属触媒と有機触媒の組み合わせによる触媒反応2012

    • Author(s)
      近藤梓, 寺田眞浩
    • Journal Title

      化学

      Volume: 67 (6) Pages: 66-67

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Enantioselective Carbon-Carbon Bond Forming Reactions Catalyzed by Chiral Phosphoric Acid Catalysts2011

    • Author(s)
      M. Terada
    • Journal Title

      Curr. Org. Chem.

      Volume: 15 Issue: 13 Pages: 2227-2256

    • DOI

      10.2174/138527211796150732

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Chiral Phosphoric Acids as Versatile Catalysts for Enantioselective Transformations2013

    • Author(s)
      M. Terada
    • Organizer
      The 23rd French-Japanese Symposium on Medicinal and Fine Chemistry
    • Place of Presentation
      Nagasaki, Japan
    • Year and Date
      2013-05-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Chiral Anion Catalysis in Enantioselective Transformation of Carbocation Intermediates2013

    • Author(s)
      M. Terada
    • Organizer
      4th UK/Japan Conference in Catalytic Asymmetric Synthesis
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Chiral Anion Catalysis inEnantioselective 1,4-Reduction of1-Benzopyrylium Ion as a Reactive Intermediate2012

    • Author(s)
      M. Terada
    • Organizer
      First Japan-USA Organocatalytic Symposium
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2012-12-16
    • Related Report
      2012 Final Research Report
  • [Presentation] キラルブレンステッド酸触媒による不斉合成2012

    • Author(s)
      寺田眞浩
    • Organizer
      日本化学会・関東支部講演会
    • Place of Presentation
      東京
    • Year and Date
      2012-08-31
    • Related Report
      2012 Final Research Report
  • [Presentation] キラルブレンステッド酸触媒による不斉合成:水素結合を戦略的相互作用とした不斉触媒反応系の開拓2012

    • Author(s)
      寺田眞浩
    • Organizer
      有機反応機構研究会
    • Place of Presentation
      大阪
    • Year and Date
      2012-08-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Enantioselective Carbon-Carbon Bond Forming Reactions Catalyzed by Chiral Phosphoric Acids2012

    • Author(s)
      M. Terada
    • Organizer
      Molecular Chirality ASIA2012
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2012-05-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Enantioselective Carbon-Carbon Bond Forming Reactions Catalyzed by Chiral Phosphoric Acids2012

    • Author(s)
      M. Terada
    • Organizer
      4th Novel Chiral Chemistries Japan 2012
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2012-03-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Enantioselective Carbon-Carbon Bond Forming Reactions Catalyzed by Chiral Phosphoric Acids2012

    • Author(s)
      M. Terada
    • Organizer
      Molecular Chirality Asia 2012
    • Place of Presentation
      Fukuoka
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] キラルブレンステッド酸による不斉合成2012

    • Author(s)
      寺田眞浩
    • Organizer
      日本化学会関東支部 地区講演会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Enantioselective Transformations via Activation of Electron-Rich Double Bonds Using Chiral Phosphoric Acids2011

    • Author(s)
      M. Terada
    • Organizer
      International Symposium of Catalysis and Fine Chemicals2011
    • Place of Presentation
      Nara, Japan
    • Year and Date
      2011-12-07
    • Related Report
      2012 Final Research Report
  • [Presentation] キラルブレンステッド酸触媒を用いた不斉合成:金属錯体との融合を目指して2011

    • Author(s)
      寺田眞浩
    • Organizer
      第39回オルガノメタリックセミナー<錯体触媒化学のフロンティア>
    • Place of Presentation
      東京工業大学,東京
    • Year and Date
      2011-11-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Enantioselective Transformations via Activation of Electron-Rich Double Bonds Using Chiral Phosphoric Acids2011

    • Author(s)
      M. Terada
    • Organizer
      FirstGermany-Japan Organocatalytic Symposium
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2011-10-14
    • Related Report
      2012 Final Research Report
  • [Presentation] キラルブレンステッド酸触媒を用いた不斉合成:金属錯体との融合を目指して

    • Author(s)
      寺田眞浩
    • Organizer
      第39回 オルガノメタリックセミナー<錯体触媒化学のフロンティア>(招待講演)
    • Place of Presentation
      東京工業大学, 東京
    • Related Report
      2011 Research-status Report
  • [Book] 最新のトピックス:触媒の"ハイブリッド"-金属触媒と有機触媒の組み合わせによる触媒反応2012

    • Author(s)
      近藤梓,寺田眞浩
    • Publisher
      化学
    • Related Report
      2012 Final Research Report
  • [Book] Science of Synthesis, Asymmetric Organocatalysis 2, Bronsted Base and Acid Catalysts, and Additional Topics (Phosphoric Acid Catalysis of Reactions not Involving Imines) Ed. K. Maruoka2012

    • Author(s)
      M. Terada
    • Publisher
      Georg Thieme Verlag KG
    • Related Report
      2012 Annual Research Report
  • [Book] 触媒調整ハンドブック第4編均一系触媒,エヌ・ティー・エス2011

    • Author(s)
      寺田眞浩
    • Publisher
      有機分子触媒
    • Related Report
      2012 Final Research Report
  • [Book] 触媒調整ハンドブック第4編 均一系触媒2011

    • Author(s)
      寺田眞浩
    • Publisher
      エヌ・ティー・エス
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.orgreact.sakura.ne.jp/publications/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 新学術領域研究「有機分子触媒による未来型分子変換」

    • URL

      http://www.organocatalysis.jp/

    • Related Report
      2012 Annual Research Report
  • [Remarks] 東北大学・大学院理学研究科・化学専攻・反応有機化学研究室HP

    • URL

      http://www.orgreact.sakura.ne.jp/index.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.orgreact.sakura.ne.jp/publications/index.html

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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