Preparation and magnetic control of metal-free magnetic emulsions and liposomes

• Project/Area Number: 23655127
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Functional materials chemistry
• Research Institution: Kyoto University
• Principal Investigator: TAMURA Rui 京都大学, 人間・環境学研究科(研究院), 教授 (60207256)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: メタルフリー磁性ソフトマテリアル / 磁性ミセル / 磁性エマルション / 磁性ヒドロゲル / ラジカルヒドロゲル / 両親媒性ラジカル化合物 / 正の磁気液晶効果 / 電子スピン共鳴分光法 / メタルフリー磁性キャリアー / メタルフリー磁性粒子 / 磁性ゲル / MRI造影剤 / 磁性ソフトマテリアル

Research Abstract

With a view to developing metal-free magnetic carriers or particles for Drug Delivery System or the MRI contrast agents, respectively, we have investigated the preparation of (i) organic nitroxide radical compounds showing surface-activity and (ii) metal-free magnetic micelles and emulsions from them. Consequently, the stable emulsions of the amphiphilic radical compound encapsulating a neutral oily nitroxide radical compound have been prepared and moved freely in water under the action of a weak permanent magnet.

Research Products

• [Journal Article] Influence of applied electric fields on the positive magneto-LC effects observed in the ferroelectric liquid crystalline phase of a chiral nitroxide radical compound (2013)
  • Author(s): K. Suzuki, Y. Uchida, R. Tarnira, Y. Noda, N. Ikuian, S. Shimono, J. Yamauch
  • Journal Title: Soft Matter Volume: 9 Issue: 18 Pages: 4687-4692
  • DOI: 10.1039/c3sm27295h
  • Peer Reviewed
• [Journal Article] Electric Field Dependence of Molecular Orientation and Anisotropic Magnetic Interactions in the Ferroelectric Liquid Crystalline Phase of an Organic Radical Compound by EPR Spectroscopy (2013)
  • Author(s): K. Suzuki, Y. Uchida, R. Tamura, Y. Noda, N. Ikuman, S. Shimono, J. Yanauch
  • Journal Title: Adevanced Sciences and Technologies Volume: 82 Pages: 50-54
  • DOI: 10.4028/www.scientific.net/ast.82.50
  • Peer Reviewed
• [Journal Article] EPR Characterization of Diamagnetic and Magnetic Organic Soft Materials Using Nitroxide Spin Probe Techniques (2012)
  • Author(s): R. Tamura, K. Suzuki, Y. Uchida, Y. Noda
  • Journal Title: Electron Paramagnetic Resonance Volume: 23 Pages: 1-21
  • DOI: 10.1039/9781849734837-00001
  • ISBN: 9781849731683, 9781849734837
  • Peer Reviewed
• [Journal Article] Magneto-LC Effects in Hydrogen-Bonded All-Organic Radical Liquid Crystal (2012)
  • Author(s): Yoshiaki Uchida, Katsuaki Suzuki, Rui Tamura
  • Journal Title: The Journal of Physical Chemistry B Volume: 116 Pages: 9791-9795
  • Peer Reviewed
• [Journal Article] Observation of positive and negative magneto-LC effects in all-organic nitroxide radical liquid crystals by EPR spectroscopy (2012)
  • Author(s): 鈴木克明(共著)
  • Journal Title: Journal of Materials Chemistry Volume: 22 Issue: 14 Pages: 6799-6806
  • DOI: 10.1039/c2jm16278d
  • Peer Reviewed
• [Presentation] キラル有機ラジカルヒドロゲル化剤のゲル化能とその磁性ヒドロゲルの性質 (2014)
  • Author(s): 武元 佑紗
  • Organizer: 日本化学会第94春季年会
  • Place of Presentation: 名古屋大学
• [Presentation] ニトロキシドラジカル液体シエルを持つ単分散エマルション液滴 (2014)
  • Author(s): 内田 幸明
  • Organizer: 日本化学会第94春季年会
  • Place of Presentation: 名古屋大学
• [Presentation] Influence of Applied Electric Fields on the Positive Magneto-LC Effects Observed in the Ferroelectric Liquid Crystalline Phase of a Chiral Nitroxide Radical Compound (2013)
  • Author(s): Rui Tamura, et al
  • Organizer: The 1st Awaji International Workshop on Electric Spin Science & Technology : Biological and Materials Science Oriented Applications
  • Place of Presentation: Awaji Island, Japan
  • Invited
• [Presentation] Preparation and Magnetic Properties of Metal-Free Magnetic Liquid Crystalline Materials Based on Nitroxide Radical Chemistry (2013)
  • Author(s): Rui Tamura
  • Organizer: 18th European Symposium on Organic Chemistry
  • Place of Presentation: Marseille, France
• [Presentation] Influence of Applied Electric Fields on the Positive Magneto-LC Effects Observed in the Ferroelectric Liquid Crystalline Phase of a Chiral Nitroxide Radical Compound (2013)
  • Author(s): Rui Tamura
  • Organizer: 12th European Conference on Liquid Crystals
  • Place of Presentation: Rhodes Island, Greece
• [Presentation] Nonuniform Intermolecular Magnetic Interactions in Nitroxide Radical Liquid Crystals (2013)
  • Author(s): Yoshiaki Uchida, Naohiko Ikuma, Katsuaki Suzuki, Rui Tamura
  • Organizer: The 7th Japanese-Russian International Workshop on Open Shell Compounds and Molecular Spin Devices
  • Place of Presentation: Awaji Island, Japan
  • Invited
• [Presentation] キラル有機ラジカルヒドロゲル化剤のゲル化能とその磁性ヒドロゲルの性質 (2013)
  • Author(s): 武元 佑紗
  • Organizer: 第24回基礎有機化学討論会
  • Place of Presentation: 東京 学習院大学
• [Presentation] ニトロキシドラジカルを有するメタルフリー磁性ソフトマテリアルの調製と性質 (2013)
  • Author(s): 大西 啓太
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 立命館大学びわこくさつキャンパス
• [Presentation] キラル有機化合物の相転移が誘起する特異な化学現象 : 磁気液晶効果と優先富化現象の発見 (2012)
  • Author(s): 田村類
  • Organizer: 第16回液晶化学研究会シンポジウム
  • Place of Presentation: 横浜国立大学
  • Year and Date: 2012-05-18
  • Invited
• [Presentation] Magnetic Properties of All-Organic Nitroxide Radical Ferroelectric Liquid Crystals (2012)
  • Author(s): Rui Tamura
  • Organizer: 4th International Conference Smart Materials Structures Systems
  • Place of Presentation: Montecatini Terme, Italy.
  • Invited
• [Presentation] Observation of Magneto-LC Effects in All-Organic Nitroxide Radical Liquid Crystals under Weak Magnetic Fields (2012)
  • Author(s): Rui Tamura, et al
  • Organizer: The 2nd International Symposium on Electron Spin Science
  • Place of Presentation: Matsushima, Japan
• [Presentation] Preparation and Magnetic Properties of Metal-Free Magnetic Soft Materials Containing a Proxyl Group (2012)
  • Author(s): Rui Tamura, et al
  • Organizer: 6th International Conference : High-Spin Molecules and Molecular Magnets
  • Place of Presentation: Rostov-on-Don, Russia
  • Invited
• [Presentation] Preparation and Properties of Amphiphilic Nitroxide Radical Compounds (2012)
  • Author(s): Keita Onishi
  • Organizer: International Association of Colloid and Interface Scientists
  • Place of Presentation: 仙台国際センター
• [Presentation] Preparation of Chiral Organic Radical Gelators and Properties of Their Supramolecular Magnetic Hudrogels (2012)
  • Author(s): Rui Tamura
  • Organizer: Molecular Chirality Asia 2012
  • Place of Presentation: 九州大学
• [Presentation] キラル有機化合物の相転移が誘起する特異な化学現象：磁気液晶効果と優先富化現象の発見 (2012)
  • Author(s): 田村 類
  • Organizer: 第16回液晶化学研究会シンポジウム
  • Place of Presentation: 横浜国立大学
  • Invited
• [Presentation] Preparation and Magnetic Properties of Metal-Free Magnetic Soft Materials Containing a Proxyl Group (2012)
  • Author(s): Rui Tamura
  • Organizer: VI International Conference: High-Spin Molecules and
  • Place of Presentation: ロストフオンドン, ロシア
  • Invited
• [Presentation] ニトロキシドラジカルを成分とするメタルフリーな磁性ソフトマテリアルの調製と性質 (2012)
  • Author(s): 大西 啓太
  • Organizer: 第23回基礎有機化学討論会
  • Place of Presentation: 京都テルサ
• [Presentation] Preparation and Magnetic Properties of Metal-Free Organic Magnetic Soft Materials Containing a Nitroxide Radical Structure (2012)
  • Author(s): Keita Ohishi
  • Organizer: 12th International Kyoto Conference on New Aspects of Organic Chemistry
  • Place of Presentation: リーガロイヤルホテル, 京都
• [Presentation] キラル純有機ニトロキシドモノ及びビラジカル化合物の合成とそれらの液晶相中における特異な磁気物性 (2012)
  • Author(s): 鈴木 克明
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶応大学（横浜市）
• [Presentation] 両親媒性有機ニトロキシドラジカル化合物の調製と物性 (2012)
  • Author(s): 大西 啓太
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶応大学（横浜市）
• [Presentation] 有機ラジカルゲル化剤の合成と磁性超分子ヒドロゲルの性質 (2012)
  • Author(s): 山本 貴之
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶応大学（横浜市
• [Presentation] Preparation and Magnetic Properties of Magnetic Soft Materials Based on Nitroxide Radical Chemistry (2011)
  • Author(s): Rui Tamura, et al
  • Organizer: 6th Conference on Synthesis, Properties and Implications of Nitroxides (SPIN 2011)
  • Place of Presentation: Marseille, France
  • Invited
• [Presentation] Magnetic Properties of Metal-Free Soft Magnetic Materials Based on Nitroxide Radical Chemistry (2011)
  • Author(s): Rui Tamrua
  • Organizer: The 5th Japanese-Russian Workshop on Open Shell Compounds and Molecular Devices
  • Place of Presentation: Awaji Island, Japan
  • Invited
• [Presentation] 正または負の誘電異方性を持つ有機ラジカル液晶性化合物の磁気相互作用 (2011)
  • Author(s): 鈴木 克明
  • Organizer: 2011年日本液晶学会討論会
  • Place of Presentation: 東京都市大学
• [Presentation] 純有機常磁性液晶のSmA*-SmC*転移付近のde Vries 挙動 (2011)
  • Author(s): 内田 幸明
  • Organizer: 2011年日本液晶学会討論会
  • Place of Presentation: 東京都市大学
• [Presentation] 正または負の誘電異方性を持つ有機ラジカル液晶性化合物の磁気相互作用 (2011)
  • Author(s): 鈴木 克明
  • Organizer: 第22回基礎有機化学討論会
  • Place of Presentation: つくば国際会議場
• [Presentation] 有機ラジカル超分子ゲル化剤の合成と磁性ヒドロゲルの性質 (2011)
  • Author(s): 山本 貴之
  • Organizer: 第22回基礎有機化学討論会
  • Place of Presentation: つくば国際会議場
• [Presentation] 両親媒性有機ニトロキシドラジカル化合物の合成と物性 (2011)
  • Author(s): 大西 啓太
  • Organizer: 第22回基礎有機化学討論会
  • Place of Presentation: つくば国際会議場
• [Presentation] Preparation and Magnetic Properties of Metal-Free Magnetic Soft Materials Based on Nitroxide Radical Chemistry (2011)
  • Author(s): Rui Tamura
  • Organizer: 6th Conference on Synthesis, Properties and Implications of Nitorxides(招待講演)
  • Place of Presentation: フランス・マルセーユ
• [Presentation] Synthesis, Stereochemistry, and Magnetic Properties of Novel Nitroxide Biradicals with a Cyclohexane Linker (2011)
  • Author(s): Satoshi Shimono
  • Organizer: 6th Conference on Synthesis, Properties and
  • Place of Presentation: フランス・マルセーユ
• [Presentation] Synthesis and Properties of All-Organic Radical Amphiphilic Compounds (2011)
  • Author(s): Keita Onishi
  • Organizer: 6th Conference on Synthesis, Properties and
  • Place of Presentation: フランス・マルセーユ
• [Presentation] Observation of Anisotropic Magnetic Interactions in All-Organic Radical Liquid Crystals (2011)
  • Author(s): Katsuaki Suzuki
  • Organizer: 6th Conference on Synthesis, Properties and
  • Place of Presentation: フランス・マルセーユ
• [Presentation] Synthesis and Properties of Nitroxide Radical Amphiphilic Compounds (2011)
  • Author(s): Keita Onishi
  • Organizer: The 5th Japanese-russian workshop on Open Shell Compounds and Molecular Spin Devices
  • Place of Presentation: 淡路島夢舞台国際会議場
• [Presentation] Magnetic Properties of Metal-Free Soft Magnetic Materials Based on Nitroxide Radical Chemistry (2011)
  • Author(s): Rui Tamura
  • Organizer: The 5th Japanese-russian workshop on Open Shell Compounds and Molecular Spin Devices(招待講演)
  • Place of Presentation: 淡路島夢舞台国際会議場
• [Book] Liquid Crystals Beyond Display : Chemistry, Physics, and Applications (2012)
  • Author(s): Rui Tamura, Yoshiaki Uchida, Katsuaki Suzuki, Q. Li (ed.)
  • Publisher: John Wiley & Sons
• [Book] Theory, Experiment and Applications (2012)
  • Author(s): Rui Tamura, Yoshiaki Uchida, Katsuaki Suzuki, Nitroxides, A. I. Kokorin (ed.)
  • Publisher: INTEC
• [Book] Nitroxides: Theory, Experiment and Applications (2012)
  • Author(s): Rui Tamura
  • Total Pages: 436
  • Publisher: INTEC
• [Book] Liquid Crystals Beyond displays: Chemistry, Physics, and Applications (2012)
  • Author(s): Rui Tamura
  • Publisher: John Wiley & Sons, Inc.
• [Remarks]
  • URL: http://www.orgmater.h.kyoto-u.ac.jp/tamura/
• [Remarks] 京都大学 大学院人間・環境学研究科 田村研究室
  • URL: http://www.orgmater.h.kyoto-u.ac.jp/tamura/
• [Remarks] 田村・津江研究室紹介
  • URL: http://www.orgmater.h.kyoto-u.ac.jp/